AGE-ASSOCIATED MEMORY IMPAIRMENT: COMMUNITY-BASED STUDY

与年龄相关的记忆障碍：基于社区的研究

• 批准号: 3386469
• 负责人: GRAHAM RATCLIFF
• 金额: $ 28.06万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-30 至 1994-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3386469
• 关键词: aging; cardiovascular disorder; clinical depression; cues; dementia; epidemiology; gender difference; human subject; human therapy evaluation; memory disorders; mental disorder diagnosis; neuropsychological tests; socioeconomics

We propose a four year prospective, community-based study of Age Associated Memory Impairment (AAMI) designed to discover its characteristics, prevalence, incidence, and clinical significance. The 1,000 subjects will be drawn from a sample of 1,250 elderly adults currently participating in a cardiovascular health study in which extensive demographic and medical data are being collected. Diagnosis will be made on the basis of neuropsychological testing, subjective report and interview. Two levels of AAMI will be distinguished: The first, an age-appropriate decline in memory from presumed optimum young adult levels, is expected to be present in 25-65% of the population. The second, a more profound decline specific to memory and resulting in memory test performance which is impaired even when compared with that of their age-peers, will be much less common (probably 5-10%). The extent to which these represent qualitatively distinct entities, rather than different degrees of impairment, will be considered. The possibility that the atypical form is the forerunner of an impending dementia will be investigated. Evaluations will be repeated after 18 months (in year three) to discover the extent to which AAMI is progressive, how it progresses and to look for now incident cases. The relationship between AAMI, cardiovascular disease, depression and other forms of comorbidity will be examined. Two additional studies involving small subsets of the AAMI sample will be integrated into the core project. One will be a cognitive neuropsychological study of memory impaired subjects designed to discover the extent to which the memory impairment of AAMI qualitatively resembles that seen in dementia. The other substudy will be a treatment trial investigating the extent to which training in the use of external memory aids, and other compensatory techniques can reduce the impact of AAMI on daily life.

我们提出了一项为期四年的前瞻性，以社区为基础的研究，年龄相关的 记忆障碍（AAMI）旨在发现其特征， 患病率、发病率和临床意义。1,000名实验对象将 从1,250名目前参加一项 一项心血管健康研究， 正在收集。诊断将根据以下因素进行： 神经心理测试、主观报告和访谈。两级 AAMI将区分为：第一，与年龄相适应的记忆力下降 从假定的最佳年轻成人水平，预计将存在于 占人口的25 - 65%。第二，一个更深刻的下降， 存储器并导致存储器测试性能受损，即使当 与同龄人相比， 5 - 10%）。它们在质量上的不同程度 将考虑实体，而不是不同程度的减值。 非典型形式是一种即将发生的 痴呆症将被调查。18个月后将重复评估 (in第三年），以发现AAMI的进步程度， 并寻找现在发生的事件。的关系 AAMI、心血管疾病、抑郁症和其他形式的合并症 将被审查。 另外两项涉及AAMI样本小子集的研究将在 融入核心项目。一个是认知的 对记忆受损受试者的神经心理学研究旨在发现 AAMI的记忆损害在性质上类似于 这在痴呆症中可见。另一项子研究将是一项治疗试验 调查使用外部记忆的训练 艾滋病和其他补偿技术可以减少AAMI对 日常生活