Personalised Adaptive Medicine

个性化药物制剂是一个热门话题，但现有技术的方法受到低可扩展性、成本和监管障碍的限制，而目前的聚药丸制剂努力受到液体形式或热熔添加方法的阻碍，造成稳定性问题。这些瓶颈带来了巨大的社会代价，因为最近证明药物组合的协同增效可以显着改善治疗效果，而将活性物质保持在理想的生理浓度窗口可以最大限度地提高效率并减少副作用。此外，多种药物是一个真实的问题，导致给药错误和患者依从性的显著损失。最后，虽然大数据健康IT系统概念在遥远的地平线上有可能收集循证个性化医疗所需的大量可靠的剂量-患者数据，但提供此类数据的技术-具有双向数字信息流的良好跟踪的患者/给药程序-仍然缺失。PERAMEDIC项目提出了一个突破性的解决方案来解决这些问题：一个用于个性化医疗的独立药物配方系统，提供本地制备的，个性化定制的，分段释放的聚药丸，具有固有的数字技术界面。该系统依赖于集成几种新技术：个人释放曲线，使用自适应工具路径的释放矩阵的原位3D打印，以及将药物超精确的多通道粉末给药到密封的微室中。设想的装置将是一个桌面大小的药丸/胶囊打印机，使用粉末状药物和生物可吸收聚合物基质材料的罐。应用场景将首先是临床环境，然后是后期阶段，药房位置和医疗实践，如GP的办公室。PERAMEDIC将提供一个实验室规模的概念验证原型系统的功能组合的新技术，与预览设计的未来技术。

Personalised drug formulation is a hot topic butstate of the art approaches are limited by low scalability, cost, and regulatory hurdles, while current polypill formulation efforts are hindered by liquid form or hot melt addition approaches, posing stability issues. These bottlenecks carry a great societal price, as the synergic boost of drug combinations was recently demonstrated to reach significant improvement in treatment outcomes, while keeping active substances in the ideal physiological concentration window is known to maximise efficiency and reduce side effects. Also, polypharmacy is a real problem leading to dosing errors and significant loss in patient adherence. Finally, while Big Data Health IT system concepts on the far horizon hold potential to gather the large amount of reliable dosage-patient data required for evidence-based personalised medicine, the technology to deliver such data – well-tracked patient/dosing procedures with bi-directional digital information flow – is missing. The PERAMEDIC project proposes to resolve these problems with a breakthrough solution: a stand-alone drug formulation system for personalised medicine, offering locally prepared, individually customised,segmented release polypills, with an inherently digital technology interface. The system relies on integrating several novel technologies: personal release profiles, in situ 3D printing of release matrix using adaptive toolpaths, and ultra-precise multichannel powder dosing of drugs into sealed microcompartments. The envisaged device would be a desktop-size pill/capsule printing machine, using canisters of powdered drugs and bioresorbable polymer matrix material. Application scenarios would be first clinical settings, then at later stage, pharmacy locations and medical practices such as GP’s office. PERAMEDIC will deliver a lab-scale proof-of-concept prototype system of the functionally combined novel technologies, with a preview design of the future technology.