Personalised Adaptive Medicine
个性化适应性医学
基本信息
- 批准号:10100435
- 负责人:
- 金额:$ 80.89万
- 依托单位:
- 依托单位国家:英国
- 项目类别:EU-Funded
- 财政年份:2024
- 资助国家:英国
- 起止时间:2024 至 无数据
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Personalised drug formulation is a hot topic butstate of the art approaches are limited by low scalability, cost, and regulatory hurdles, while current polypill formulation efforts are hindered by liquid form or hot melt addition approaches, posing stability issues. These bottlenecks carry a great societal price, as the synergic boost of drug combinations was recently demonstrated to reach significant improvement in treatment outcomes, while keeping active substances in the ideal physiological concentration window is known to maximise efficiency and reduce side effects. Also, polypharmacy is a real problem leading to dosing errors and significant loss in patient adherence. Finally, while Big Data Health IT system concepts on the far horizon hold potential to gather the large amount of reliable dosage-patient data required for evidence-based personalised medicine, the technology to deliver such data – well-tracked patient/dosing procedures with bi-directional digital information flow – is missing. The PERAMEDIC project proposes to resolve these problems with a breakthrough solution: a stand-alone drug formulation system for personalised medicine, offering locally prepared, individually customised,segmented release polypills, with an inherently digital technology interface. The system relies on integrating several novel technologies: personal release profiles, in situ 3D printing of release matrix using adaptive toolpaths, and ultra-precise multichannel powder dosing of drugs into sealed microcompartments. The envisaged device would be a desktop-size pill/capsule printing machine, using canisters of powdered drugs and bioresorbable polymer matrix material. Application scenarios would be first clinical settings, then at later stage, pharmacy locations and medical practices such as GP’s office. PERAMEDIC will deliver a lab-scale proof-of-concept prototype system of the functionally combined novel technologies, with a preview design of the future technology.
个性化药物制剂是一个热门话题,但现有技术的方法受到低可扩展性、成本和监管障碍的限制,而目前的聚药丸制剂努力受到液体形式或热熔添加方法的阻碍,造成稳定性问题。这些瓶颈带来了巨大的社会代价,因为最近证明药物组合的协同增效可以显着改善治疗效果,而将活性物质保持在理想的生理浓度窗口可以最大限度地提高效率并减少副作用。此外,多种药物是一个真实的问题,导致给药错误和患者依从性的显著损失。最后,虽然大数据健康IT系统概念在遥远的地平线上有可能收集循证个性化医疗所需的大量可靠的剂量-患者数据,但提供此类数据的技术-具有双向数字信息流的良好跟踪的患者/给药程序-仍然缺失。PERAMEDIC项目提出了一个突破性的解决方案来解决这些问题:一个用于个性化医疗的独立药物配方系统,提供本地制备的,个性化定制的,分段释放的聚药丸,具有固有的数字技术界面。该系统依赖于集成几种新技术:个人释放曲线,使用自适应工具路径的释放矩阵的原位3D打印,以及将药物超精确的多通道粉末给药到密封的微室中。设想的装置将是一个桌面大小的药丸/胶囊打印机,使用粉末状药物和生物可吸收聚合物基质材料的罐。应用场景将首先是临床环境,然后是后期阶段,药房位置和医疗实践,如GP的办公室。PERAMEDIC将提供一个实验室规模的概念验证原型系统的功能组合的新技术,与预览设计的未来技术。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
其他文献
Internet-administered, low-intensity cognitive behavioral therapy for parents of children treated for cancer: A feasibility trial (ENGAGE).
针对癌症儿童父母的互联网管理、低强度认知行为疗法:可行性试验 (ENGAGE)。
- DOI:
10.1002/cam4.5377 - 发表时间:
2023-03 - 期刊:
- 影响因子:4
- 作者:
- 通讯作者:
Differences in child and adolescent exposure to unhealthy food and beverage advertising on television in a self-regulatory environment.
在自我监管的环境中,儿童和青少年在电视上接触不健康食品和饮料广告的情况存在差异。
- DOI:
10.1186/s12889-023-15027-w - 发表时间:
2023-03-23 - 期刊:
- 影响因子:4.5
- 作者:
- 通讯作者:
The association between rheumatoid arthritis and reduced estimated cardiorespiratory fitness is mediated by physical symptoms and negative emotions: a cross-sectional study.
类风湿性关节炎与估计心肺健康降低之间的关联是由身体症状和负面情绪介导的:一项横断面研究。
- DOI:
10.1007/s10067-023-06584-x - 发表时间:
2023-07 - 期刊:
- 影响因子:3.4
- 作者:
- 通讯作者:
ElasticBLAST: accelerating sequence search via cloud computing.
ElasticBLAST:通过云计算加速序列搜索。
- DOI:
10.1186/s12859-023-05245-9 - 发表时间:
2023-03-26 - 期刊:
- 影响因子:3
- 作者:
- 通讯作者:
Amplified EQCM-D detection of extracellular vesicles using 2D gold nanostructured arrays fabricated by block copolymer self-assembly.
使用通过嵌段共聚物自组装制造的 2D 金纳米结构阵列放大 EQCM-D 检测细胞外囊泡。
- DOI:
10.1039/d2nh00424k - 发表时间:
2023-03-27 - 期刊:
- 影响因子:9.7
- 作者:
- 通讯作者:
的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('', 18)}}的其他基金
An implantable biosensor microsystem for real-time measurement of circulating biomarkers
用于实时测量循环生物标志物的植入式生物传感器微系统
- 批准号:
2901954 - 财政年份:2028
- 资助金额:
$ 80.89万 - 项目类别:
Studentship
Exploiting the polysaccharide breakdown capacity of the human gut microbiome to develop environmentally sustainable dishwashing solutions
利用人类肠道微生物群的多糖分解能力来开发环境可持续的洗碗解决方案
- 批准号:
2896097 - 财政年份:2027
- 资助金额:
$ 80.89万 - 项目类别:
Studentship
A Robot that Swims Through Granular Materials
可以在颗粒材料中游动的机器人
- 批准号:
2780268 - 财政年份:2027
- 资助金额:
$ 80.89万 - 项目类别:
Studentship
Likelihood and impact of severe space weather events on the resilience of nuclear power and safeguards monitoring.
严重空间天气事件对核电和保障监督的恢复力的可能性和影响。
- 批准号:
2908918 - 财政年份:2027
- 资助金额:
$ 80.89万 - 项目类别:
Studentship
Proton, alpha and gamma irradiation assisted stress corrosion cracking: understanding the fuel-stainless steel interface
质子、α 和 γ 辐照辅助应力腐蚀开裂:了解燃料-不锈钢界面
- 批准号:
2908693 - 财政年份:2027
- 资助金额:
$ 80.89万 - 项目类别:
Studentship
Field Assisted Sintering of Nuclear Fuel Simulants
核燃料模拟物的现场辅助烧结
- 批准号:
2908917 - 财政年份:2027
- 资助金额:
$ 80.89万 - 项目类别:
Studentship
Assessment of new fatigue capable titanium alloys for aerospace applications
评估用于航空航天应用的新型抗疲劳钛合金
- 批准号:
2879438 - 财政年份:2027
- 资助金额:
$ 80.89万 - 项目类别:
Studentship
CDT year 1 so TBC in Oct 2024
CDT 第 1 年,预计 2024 年 10 月
- 批准号:
2879865 - 财政年份:2027
- 资助金额:
$ 80.89万 - 项目类别:
Studentship
Developing a 3D printed skin model using a Dextran - Collagen hydrogel to analyse the cellular and epigenetic effects of interleukin-17 inhibitors in
使用右旋糖酐-胶原蛋白水凝胶开发 3D 打印皮肤模型,以分析白细胞介素 17 抑制剂的细胞和表观遗传效应
- 批准号:
2890513 - 财政年份:2027
- 资助金额:
$ 80.89万 - 项目类别:
Studentship
Understanding the interplay between the gut microbiome, behavior and urbanisation in wild birds
了解野生鸟类肠道微生物组、行为和城市化之间的相互作用
- 批准号:
2876993 - 财政年份:2027
- 资助金额:
$ 80.89万 - 项目类别:
Studentship
相似海外基金
Precision Medicine in Alzheimer’s Disease: A SMART Trial of Adaptive Exercises and Their Mechanisms of Action Using AT(N) Biomarkers to Optimize Aerobic-Fitness Responses
阿尔茨海默病的精准医学:使用 AT(N) 生物标志物优化有氧健身反应的适应性运动及其作用机制的 SMART 试验
- 批准号:
10581973 - 财政年份:2023
- 资助金额:
$ 80.89万 - 项目类别:
Determining the long-term outcomes and optimal treatment of childhood nephrotic syndrome using population-based administrative health data, target trial emulation, and a pilot adaptive clinical trial of a precision medicine treatment strategy
使用基于人群的管理健康数据、目标试验模拟和精准医学治疗策略的试点适应性临床试验来确定儿童肾病综合征的长期结果和最佳治疗
- 批准号:
475537 - 财政年份:2022
- 资助金额:
$ 80.89万 - 项目类别:
Studentship Programs
Addiction Medicine Consult Teams as Complex Adaptive Systems: An Exploratory Case Study
成瘾医学咨询团队作为复杂的自适应系统:探索性案例研究
- 批准号:
458237 - 财政年份:2021
- 资助金额:
$ 80.89万 - 项目类别:
Miscellaneous Programs
Evaluating a precision medicine approach to nephrotic syndrome using novel genetic risk profiles: A pilot adaptive clinical trial
使用新的遗传风险特征评估肾病综合征的精准医学方法:一项试点适应性临床试验
- 批准号:
466596 - 财政年份:2021
- 资助金额:
$ 80.89万 - 项目类别:
Studentship Programs
The RECLAIM (REcovering from COVID-19 Lingering symptoms Adaptive Integrative Medicine) trial
RECLAIM(从 COVID-19 挥之不去的症状中恢复适应性综合医学)试验
- 批准号:
448867 - 财政年份:2021
- 资助金额:
$ 80.89万 - 项目类别:
Operating Grants
EAGER: SCH: Distributed and Adaptive Personalized Medicine
EAGER:SCH:分布式和自适应个性化医疗
- 批准号:
1723483 - 财政年份:2017
- 资助金额:
$ 80.89万 - 项目类别:
Standard Grant
SBIR Phase I: Adaptive E-Triage in Emergency Medicine
SBIR 第一阶段:急诊医学中的自适应电子分诊
- 批准号:
1621899 - 财政年份:2016
- 资助金额:
$ 80.89万 - 项目类别:
Standard Grant
Personalized medicine using registry cohort data: Developing an adaptive treatment strategy to prevent and treat graft-versus-host disease
使用登记队列数据的个性化医疗:制定预防和治疗移植物抗宿主病的适应性治疗策略
- 批准号:
363271 - 财政年份:2016
- 资助金额:
$ 80.89万 - 项目类别:
Operating Grants
Adaptive Optics for Australian Astronomy, Medicine, Industry, and Defence
用于澳大利亚天文学、医学、工业和国防的自适应光学
- 批准号:
SR0354517 - 财政年份:2003
- 资助金额:
$ 80.89万 - 项目类别:
Special Research Initiatives