Personalised Adaptive Medicine

个性化适应性医学

• 批准号: 10100435
• 金额: $ 80.89万
• 依托单位: LOUGHBOROUGH UNIVERSITY
• 依托单位国家: 英国
• 项目类别: EU-Funded
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10100435
• 关键词: Personalised; Adaptive; Medicine

Personalised drug formulation is a hot topic butstate of the art approaches are limited by low scalability, cost, and regulatory hurdles, while current polypill formulation efforts are hindered by liquid form or hot melt addition approaches, posing stability issues. These bottlenecks carry a great societal price, as the synergic boost of drug combinations was recently demonstrated to reach significant improvement in treatment outcomes, while keeping active substances in the ideal physiological concentration window is known to maximise efficiency and reduce side effects. Also, polypharmacy is a real problem leading to dosing errors and significant loss in patient adherence. Finally, while Big Data Health IT system concepts on the far horizon hold potential to gather the large amount of reliable dosage-patient data required for evidence-based personalised medicine, the technology to deliver such data – well-tracked patient/dosing procedures with bi-directional digital information flow – is missing. The PERAMEDIC project proposes to resolve these problems with a breakthrough solution: a stand-alone drug formulation system for personalised medicine, offering locally prepared, individually customised,segmented release polypills, with an inherently digital technology interface. The system relies on integrating several novel technologies: personal release profiles, in situ 3D printing of release matrix using adaptive toolpaths, and ultra-precise multichannel powder dosing of drugs into sealed microcompartments. The envisaged device would be a desktop-size pill/capsule printing machine, using canisters of powdered drugs and bioresorbable polymer matrix material. Application scenarios would be first clinical settings, then at later stage, pharmacy locations and medical practices such as GP’s office. PERAMEDIC will deliver a lab-scale proof-of-concept prototype system of the functionally combined novel technologies, with a preview design of the future technology.

个性化的药物配方是一个热门话题，但是艺术方法的局势受到低扩展性，成本和监管障碍的限制，而当前的Polypill公式努力受到液体形式或热融化添加方法的阻碍，从而带来了稳定性问题。这些瓶颈具有巨大的社会价格，因为最近证明药物组合的协同增强可以在治疗结果上取得重大改善，同时将活性物质保持在理想的生理浓度窗口中可以最大程度地提高效率并降低副作用。同样，多药是一个真正的问题，导致给药错误和患者依从性的显着丧失。最后，尽管大数据健康IT IT系统概念在远处远处有可能收集基于证据的个性化医学所需的大量可靠剂量 - 患者数据，但传递此类数据的技术（具有双向数字信息流动的良好传播的患者/剂量程序）缺少。 Peramamic项目的建议旨在通过突破性解决方案解决这些问题：独立的个性化医学药物配方系统，提供本地准备的，单独定制的，分割的释放polypills，并具有固有的数字技术界面。该系统依靠整合了几种新型技术：个人释放曲线，使用自适应工具路径对释放矩阵的原位3D打印，以及超级精致的多通道粉末剂量的药物剂量的药物剂量为密封的微型组件。所设想的设备将是使用粉末粉和可生物吸收的聚合物矩阵材料的罐头式药丸/胶囊打印机。应用方案将是第一个临床环境，然后在后期，药房和医疗惯例（例如GP办公室）。 Peramedic将提供实验室规模的概念验证原型系统，其功能相结合的新技术和未来技术的预览设计。