Core A: Administrative Core

行政核心（AC）的总体目标是提供一个结构，以促进实现本计划项目目标的有效互动。为实现这一目标，咨询委员会将分为指导委员会和项目管理小组。这些小组将共同努力实现以下具体目标：1）通过制定研究议程提供研究方向，重点关注解决阿巴拉契亚地区宫颈癌差异并促进跨学科研究; 2）通过提供集中的拨款管理、信息传播、预算数据处理以及无缝的信息和服务交换，确保该计划所有组成部分的运营效率;和3）促进项目和核心（调查和数据收集，干预和联盟，生物统计和评估）的整合，以促进四所大学，调查人员，阿巴拉契亚社区，参与社区诊所/卫生系统之间的互动;和相关的外部实体。拟议的AC建立在阿巴拉契亚社区癌症网络（P30 CA 016058）结构的成功经验基础上，其中多个主要研究者（MPI）共同工作了10多年。拟议的结构将由位于俄亥俄州州立大学的总部单位领导，并由MPI、Paskett博士、安德森博士、Dignan博士和Kennedy博士指导。这个团队的成员都很熟悉，并有一起进行研究项目的跟踪记录，以及每个人都有在阿巴拉契亚进行社区研究的丰富经验。我们设计了一个组织和管理结构，定义和保留明确的责任，并促进项目和核心之间的相互依赖。MPI将负责重要里程碑的日常监督，以及所有计划组成部分之间的整合。AC还将监督指导委员会的运作，这是一个外部科学咨询委员会，由来自外部机构的四名科学家组成，还将与干预和联盟核心合作，以促进社区咨询委员会和临床合作伙伴成员的投入和会议，确保在该计划的各个方面开展基于社区的前瞻性研究，并负责与生物统计和评估核心一起召开数据和安全监测委员会的定期会议。该计划还有两名顾问-Mack Ruffin博士和Jaimie Ostroff博士-分别就临床问题和实施科学提供建议。最后，咨询委员会将确保该方案的所有组成部分无缝协作，以实现该方案项目的总体和具体项目目标，并确保研究所依据的两个概念模型-解决健康差距的多层次模型（用于干预和评估）和普罗克特实施框架（用于实施和评估干预措施）得到充分接受和整合。

The overall goal of the Administrative Core (AC) is to provide a structure to facilitate effective interactions toward accomplishment of the aims of this Program Project. To accomplish this goal, the AC will be structured into a Steering Committee and a Project Management Team. These groups will work together to accomplish the following specific aims: 1) Provide research direction by setting the research agenda focused on addressing cervical cancer disparities in Appalachia and promoting transdisciplinary research; 2) Ensure operational efficiency for all components of the Program by providing centralized grant administration, information dissemination, budget data processing, and seamless exchange of information and services; and 3) Promote integration of the Projects and Cores (Survey and Data Collection, Intervention and Consortium, and Biostatistics and Evaluation) to promote interaction among the four Universities, the investigators, the Appalachian communities, the participating community clinics/health systems; and relevant external entities. The proposed AC builds upon the successful experience of the structure of the Appalachian Community Cancer Network (P30 CA016058), in which the Multiple Principal Investigators (MPIs) worked together for over 10 years. The proposed structure will be led by a Headquarters unit located at The Ohio State University and be directed by MPIs, Drs. Paskett, Anderson, Dignan and Kennedy. The members of this team are well acquainted and have a track record of conducting research projects together, as well as each has substantial experience with conducting community based research in Appalachia. We have designed an organizational and administrative structure that defines and preserves clear responsibilities and facilitates interactive dependence among projects and cores. The MPIs will be responsible for day-to-day oversight of the important milestones, and integration among all Program components. The AC will also oversee the operation of the Steering Committee, an External Scientific Advisory Committee, comprised of four scientists from outside institutions, and will also work with the Intervention and Consortium Core to facilitate input from and meetings with members of the Community Advisory Board and the Clinical Partners, assuring Community-Based Participatory Research in all the aspects of the Program, and be responsible for regular meetings of the Data and Safety Monitoring Board, in conjunction with the Biostatistics and Evaluation Core. The Program also has two consultants – Drs. Mack Ruffin and Jaimie Ostroff – to advise on clinical issues and Implementation Science, respectively. Lastly, the AC will ensure that all components of the Program work seamlessly together to accomplish the Overall and specific project goals of the Program Project and that the two conceptual models which underlie the research – the Multi-Level Model for Addressing Health Disparities (for intervention and assessment) and the Proctor Implementation Framework (for implementation and evaluation of the interventions) are fully embraced and integrated.