Administrative Core

抽象行政核心 多中心骨关节炎(MOST)研究的使命是进行、促进和促进高影响 研究骨关节炎(OA)及其疼痛和功能丧失的后果的病因和预防。 在拟议的第四个MOST周期(MOST4)期间，我们计划通过收购来实现这一目标， 管理、分析和共享有关骨科疾病、风险因素和功能后果的数据。这个 MOST4管理核心的主要目标是确保流程到位并发挥作用，以 支持完成这一使命。行政核心将管理财务，以及以下内容 互动：1)内部研究单位之间(核心(临床数据收集和管理、分析、 成像)和项目)；2)与外部研究人员；3)参与最多研究的机构之间 包括波士顿大学、阿拉巴马大学伯明翰分校、加州大学旧金山分校； 爱荷华大学；资助机构(NIA)；阅读中心；以及专门的实验室。 CORE将在CORE联合领导人David Felson博士和Tuhina Neogi的领导下，由 由其他核心的领导人组成的执行委员会。MOST4调查人员的整个团队包括一个 NIH资助的资深经验丰富的教师和初级教师的混合，以学习为重点建立他们的职业生涯 关于骨性关节炎、疼痛和残疾。社会变革管理计划研究的第一个周期(MOST1)于2001年获得资助，研究人员 隶属于这一群体的合作历史悠久，发表了180多篇论文报道 与骨性关节炎流行病学和风险因素、疼痛、功能和其他结果相关的重要发现。在这些人中 这项研究的独特之处在于其调查人员和研究具有多学科性质。一系列主题 已有研究成果，包括膝关节MRI表现、疼痛敏感度、生物力学基础数据等 反作用力，肌肉功能测量，晶体沉积研究，体力活动评估， 还有其他的。目前关于社会变革管理计划第四周期(MOST4)的提议代表了这一点的扩展 多学科聚焦。管理核心的目标是提供成功管理的领导力 整体研究的执行；计划、指导和整合所有最重要的研究活动；提供透明的 跨项目和核心的沟通；并促进跨项目合作。我们将实现这些目标 通过为以下具体目标提供领导和行政监督：科学和 业务管理，包括单一机构审查委员会程序；财务管理；研究 产出管理和传播；试点赠款方案；社区咨询委员会参与； 通信和外部协作。通过这些活动，行政核心将确保 在调查员团队的坚强和协作领导下，MOST4成功运作。

ABSTRACT Administrative Core The mission of the Multicenter Osteoarthritis (MOST) study is to conduct, facilitate, and promote high impact research on the etiology and prevention of osteoarthritis (OA) and its consequences of pain and loss of function. During the proposed 4th cycle of MOST (MOST4), we plan to accomplish this goal through the acquisition, management, analysis and sharing of data on OA, risk factors and functional consequences of disease. The primary goal of the MOST4 Administrative Core is to ensure that processes are in place and functioning to support the accomplishment of this mission. The Administrative Core will manage finances, and the following interactions: 1) internally among the study units (the Cores (Clinical Data Collection and Management, Analysis, Imaging) and Projects); 2) with external researchers; 3) between institutions involved in the MOST study including Boston University; University of Alabama, Birmingham; University of California, San Francisco; University of Iowa; the funding agency (NIA); reading centers; and specialized laboratories.The Administrative Core will be under the leadership of Core co-Leaders Drs. David Felson and Tuhina Neogi, supported by an Executive Committee consisting of the other Cores' leaders. The overall team of MOST4 investigators include a mix of senior experienced NIH-funded faculty and junior faculty establishing their careers with a focus on studies of OA, pain and disability. The first cycle of the MOST study (MOST1) was funded in 2001, and investigators affiliated with this cohort have a long history of collaboration, having published over 180 papers reporting important findings related to OA epidemiology and risk factors, pain, function, and other outcomes. Among the unique features of the study has been the multidisciplinarity of its investigators and research. A range of topics have been studied, including MRI findings in the knee, pain sensitization, biomechanical data such as the ground reaction force, measurement of muscle function, studies of crystal deposition, assessment of physical activity, among others. The current proposal for the 4th cycle of MOST (MOST4) represents an expansion of this multidisciplinary focus. The goals of the Administrative Core are to provide leadership to successfully manage the overall study's execution; plan, direct and integrate all MOST study activities; provide transparent communication across projects and cores; and foster cross-project collaboration. We will accomplish these goals through providing leadership and administrative oversight for the following Specific Aims: Scientific & Operational Management, including single Institutional Review Board processes; Financial Management; Study Output Management & Dissemination; Pilot Grant Program; Community Advisory Board Engagement; Communications & External Collaboration. Through these activities, the Administrative Core will ensure the successful operations of MOST4 under the strong and collaborative leadership of the investigator team.