Administrative Core

行政核心

• 批准号: 10555682
• 负责人: DAVID Tobin FELSON
• 金额: $ 123.81万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10555682
• 关键词: Address; Aging; Agreement; Alabama; Ancillary Study; Area; Biomechanics; Boston; California; Clinical Data; Collaborations; Communication; Communities; Crystal Formation; Data; Data Collection; Degenerative polyarthritis; Disease; Disputes; Ensure; Epidemiologic Factors; Etiology; Faculty; Feedback; Fostering; Funding; Funding Agency; Goals; Grant; Image; Institution; Institutional Review Boards; Iowa; Knee; Laboratories; Leadership; Magnetic Resonance Imaging; Measurement; Mission; Monitor; Muscle function; Observational Study; Occupational activity of managing finances; Outcome; Output; Pain; Paper; Physical activity; Physical assessment; Policies; Postdoctoral Fellow; Prevention; Process; Productivity; Protocols documentation; Publishing; Reaction; Reading; Recording of previous events; Regulation; Reporting; Research; Research Personnel; Risk Factors; San Francisco; United States National Institutes of Health; Universities; career; cohort; data management; data sharing; disability; experience; human subject; innovation; insight; loss of function; meetings; multidisciplinary; novel; operation; patient oriented; programs

ABSTRACT Administrative Core The mission of the Multicenter Osteoarthritis (MOST) study is to conduct, facilitate, and promote high impact research on the etiology and prevention of osteoarthritis (OA) and its consequences of pain and loss of function. During the proposed 4th cycle of MOST (MOST4), we plan to accomplish this goal through the acquisition, management, analysis and sharing of data on OA, risk factors and functional consequences of disease. The primary goal of the MOST4 Administrative Core is to ensure that processes are in place and functioning to support the accomplishment of this mission. The Administrative Core will manage finances, and the following interactions: 1) internally among the study units (the Cores (Clinical Data Collection and Management, Analysis, Imaging) and Projects); 2) with external researchers; 3) between institutions involved in the MOST study including Boston University; University of Alabama, Birmingham; University of California, San Francisco; University of Iowa; the funding agency (NIA); reading centers; and specialized laboratories.The Administrative Core will be under the leadership of Core co-Leaders Drs. David Felson and Tuhina Neogi, supported by an Executive Committee consisting of the other Cores' leaders. The overall team of MOST4 investigators include a mix of senior experienced NIH-funded faculty and junior faculty establishing their careers with a focus on studies of OA, pain and disability. The first cycle of the MOST study (MOST1) was funded in 2001, and investigators affiliated with this cohort have a long history of collaboration, having published over 180 papers reporting important findings related to OA epidemiology and risk factors, pain, function, and other outcomes. Among the unique features of the study has been the multidisciplinarity of its investigators and research. A range of topics have been studied, including MRI findings in the knee, pain sensitization, biomechanical data such as the ground reaction force, measurement of muscle function, studies of crystal deposition, assessment of physical activity, among others. The current proposal for the 4th cycle of MOST (MOST4) represents an expansion of this multidisciplinary focus. The goals of the Administrative Core are to provide leadership to successfully manage the overall study's execution; plan, direct and integrate all MOST study activities; provide transparent communication across projects and cores; and foster cross-project collaboration. We will accomplish these goals through providing leadership and administrative oversight for the following Specific Aims: Scientific & Operational Management, including single Institutional Review Board processes; Financial Management; Study Output Management & Dissemination; Pilot Grant Program; Community Advisory Board Engagement; Communications & External Collaboration. Through these activities, the Administrative Core will ensure the successful operations of MOST4 under the strong and collaborative leadership of the investigator team.

抽象的管理核心 多中心骨关节炎的使命是进行，促进和促进高影响力 研究骨关节炎（OA）的病因和预防及其对疼痛和功能丧失的后果的研究。 在大多数（大多数4）的提议的第四个周期中，我们计划通过收购来实现这一目标， 有关OA，危险因素和疾病功能后果的数据的管理，分析和共享。这 最多4个行政核心的主要目标是确保进程已经到位并运行到 支持完成此任务的完成。行政核心将管理财务状况，以下 互动：1）在研究单元中内部（核心（临床数据收集和管理，分析， 成像）和项目）； 2）与外部研究人员； 3）在研究最研究的机构之间 包括波士顿大学；阿拉巴马大学伯明翰；加利福尼亚大学旧金山； 爱荷华大学；资助机构（NIA）；阅读中心；和专业实验室。 核心将在核心联合领导者DRS的领导下。大卫·费尔森（David Felson）和图希纳·尼吉（Tuhina Neogi），由 由其他核心领导人组成的执行委员会。大多数4个调查人员的总体团队包括 高级经验丰富的NIH资助教师和初级教师建立职业，重点是学习 OA，疼痛和残疾。最多研究的第一个周期（最多1）是在2001年资助的，研究人员 隶属于该队列的协作历史悠久，已发表了180多篇论文报告 与OA流行病学和危险因素，疼痛，功能和其他结果有关的重要发现。在 该研究的独特特征是其研究人员和研究的多学科性。一系列主题 已经研究了，包括膝盖中的MRI发现，疼痛敏化，生物力学数据，例如地面 反作用力，肌肉功能的测量，晶体沉积研究，体育活动评估， 等等。当前关于大多数（最多4）的第四个周期的建议代表了这一点的扩展 多学科重点。行政核心的目标是提供领导才能成功管理 总体研究的执行；计划，直接和整合所有大多数研究活动；提供透明 跨项目和核心的交流；和促进跨项目的协作。我们将实现这些目标 通过为以下特定目的提供领导和行政监督：科学＆ 运营管理，包括单个机构审查委员会流程；财务管理；学习 产出管理与传播；试点赠款计划；社区咨询委员会的参与； 沟通与外部协作。通过这些活动，行政核心将确保 在调查员团队的强大和协作领导下，大多数4的成功运营。