Admin Core: Administration, Biostatistics and Data Coordinating Center

核心1摘要 行政、生物统计和临床数据库核心为以下所有三个项目提供支持 P01。国际私家侦探费拉拉博士负责整个研究项目的实施。一位高管 成员委员会(三个项目和核心领导)由PI担任主席。执行委员会 每月举行正式会议，以检讨个别项目的进度，并监察 核心，并解决任何潜在的后勤困难。UmutÖzbek博士提供生物统计学 监督在三类统计事务方面具有专门知识的所有项目：1)统计分析 临床和生物标志物数据；2)试验设计、样本量计算和分析 实验模型；3)临床试验设计和监测。莱文博士负责监督 数据协调中心，提供多项创新且经济实惠的服务。魔力 数据库目前包含5000名HCT接受者和2300例急性移植物抗宿主病患者的数据；约700名患者 (300人使用GVHD)每年。该核心开发了严格的流程，以将数据错误降至最低 数据录入前后。 核心1目标如下： 1.向所有项目和核心提供行政和财政监督，并促进 包括集中数据共享、文档生成、组织监控、 财务报告，以及对所有内部和外部机构的问责。 2.为临床和实验室数据的分析提供先进的生物统计学支持，并协助 所有项目中实验的生物统计设计。 3.监督魔术数据库的创建和管理。

CORE 1 ABSTRACT The Administration, Biostatistics and Clinical Database Core provides support for all three projects within the P01. The PI, Dr. Ferrara, is responsible for the overall conduct of this research program. An executive committee of members (the three project and core leaders) is chaired by the PI. The executive committee meets formally on a monthly basis to review progress of the individual projects, to monitor the function of the cores, and to resolve any potential logistical difficulties. Umut Özbek, Ph.D., provides biostatistical oversight to all projects with expertise in three categories of statistical services: 1) statistical analysis of clinical and biomarker data; 2) experimental design, sample size calculations and analyses in experimental models; and 3) clinical trial design and monitoring. Dr. Levine oversees the activities of the data coordinating center which provides a number of innovative and cost effective services. The MAGIC database currently contains data for 5,000 HCT recipients and 2300 acute GVHD cases; ~700 patients (300 with GVHD) per year. This core has developed rigorous processes to minimize data errors both before and after data entry. The Core 1 objectives are as follows: 1. To provide administrative and fiscal oversight to all projects and cores, and to facilitate optimal interactions including centralized data sharing, document generation, organization monitoring, financial reports, and accountability to all internal and external agencies. 2. To provide advanced biostatistical support for analysis of clinical and laboratory data and assist in the biostatistical design of experiments in all projects. 3. To oversee the creation and curation of the MAGIC database.