Molecular basis of nucleotide signalling by TIR domain containing proteins

含 TIR 结构域的蛋白质的核苷酸信号转导的分子基础

• 批准号: FT200100572
• 负责人: A/Prof Thomas Ve
• 金额: $ 58.11万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-04 至 2025-01-03
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT200100572
• 关键词: Molecular; basis; nucleotide; signalling; TIR

Nicotinamide adenine dinucleotide (NAD+) dependent signalling pathways play important roles in neurodegenerative diseases and bacterial defence systems, and are therefore potential targets for the development of new therapeutics and biotechnology tools. This project aims to increase our understanding of the biology of a novel class of enzymes involved in NAD+ signalling across the domains of life. The project is expected to unravel general principles of nucleotide-based signalling, and the expected outcomes will include new molecular mechanisms relevant to cell-death and pathogen defence in mammalian and bacterial systems, which should provide significant benefit for a range of applications in human biology and biotechnology.

烟酰胺腺嘌呤二核苷酸（NAD+）依赖性信号通路在神经退行性疾病和细菌防御系统中起重要作用，因此是开发新的治疗剂和生物技术工具的潜在目标。该项目旨在增加我们对一类涉及NAD+信号转导的新型酶的生物学的理解。预计该项目将揭示基于核苷酸的信号传导的一般原理，预期成果将包括与哺乳动物和细菌系统中的细胞死亡和病原体防御相关的新分子机制，这将为人类生物学和生物技术的一系列应用提供重大益处。