Structural basis of paramyxovirus host cell entry

副粘病毒进入宿主细胞的结构基础

• 批准号: DE170100783
• 负责人: A/Prof Thomas Ve
• 金额: $ 26.03万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE170100783
• 关键词: Structural; basis; paramyxovirus; host; cell

This project aims to investigate interactions between paramyxoviruses and host cell receptors and the mechanisms underlying fusion activation at a molecular level. Paramyxoviruses include economically important human and animal pathogens. Two viral proteins are key to infection: an attachment protein for the interaction with host receptors, and a fusion protein for fusion of viral and cellular membranes. The project is anticipated to discover general principles of how paramyxoviruses infect host cells, which should advance fundamental understanding of viral infection strategies and may identify strategies for rational design of inhibitors targeting host-cell entry of multiple paramyxoviruses.

本项目旨在从分子水平研究副粘病毒与宿主细胞受体的相互作用及其融合激活的机制。副粘病毒包括经济上重要的人类和动物病原体。两种病毒蛋白是感染的关键：用于与宿主受体相互作用的附着蛋白，以及用于融合病毒和细胞膜的融合蛋白。该项目预计将发现副粘病毒如何感染宿主细胞的一般原理，这将促进对病毒感染策略的基本理解，并可能确定针对多种副粘病毒进入宿主细胞的抑制剂的合理设计策略。