Multimodal Artificial Intelligence to Predict Glaucomatous Progression and Surgical Intervention

项目摘要 该提案的总体目标是“多模式人工智能预测青光眼进展”， 和手术干预”，是使用多模态人工智能（AI）和深度学习策略来预测 哪些青光眼患者需要青光眼手术，哪些可能有进行性视野丧失 在未来本研究旨在利用长期良好表征的临床和研究队列 青光眼患者及其经验证的决策支持AI基础设施，以预测哪些青光眼患者将 哪些需要手术，哪些需要手术。该提案包括以下两个具体目标。目标1将使用 基线电子健康记录（EHR）、视神经乳头（ONH）、光学相干断层扫描（OCT） 在多模式中，成像、视野（VF）数据、眼内压（IOP）和中央角膜厚度（CCT） DL模型预测青光眼手术干预的可能性。目标2将使用基线EHR、ONH 多模态DL模型中的OCT成像、VF数据、IOP和CCT，以预测快速昏迷的可能性 视野进展为了实现这些目标，来自青光眼患者的现有数据1）参加了 国家眼科研究所资助的青光眼诊断创新研究（DIGS 1995年至今）和非洲 血统和青光眼评估研究（ADAGES 2009-2021），以及2）在UCSD Viterbi家族管理 眼科将用于AI模型开发和测试。我们还将利用 UCSD现有的基于云的人工智能管道，以建立一个专门的平台来训练，测试，并在未来， 更新开发的深度学习模型。在未来，这种基础设施可以用来支持 人工智能引导青光眼管理的随机临床试验测试，并实现实时决策支持， 临床医生

Project Summary The overall objective of this proposal, “Multimodal Artificial Intelligence to Predict Glaucomatous Progression and Surgical Intervention”, is to use multimodal artificial intelligence (AI) and deep learning strategies to predict which glaucoma patients will need glaucoma surgery and which are likely to have progressive visual field loss in the future. This study is designed to leverage longstanding well characterized clinical and research cohorts of glaucoma patients and its validated decision support AI infrastructure to predict which glaucoma patients will progress and which will need surgery. The proposal includes the following two Specific Aims. Aim 1 will use baseline electronic health records (EHR), optic nerve head (ONH) optical coherence tomography (OCT) imaging, visual field (VF) data, intraocular pressure (IOP) and central corneal thickness (CCT) in a multimodal DL model to predict the likelihood of surgical intervention for glaucoma. Aim 2 will use baseline EHR, ONH OCT imaging, VF data, IOP and CCT in a multimodal DL model to predict the likelihood of fast glaucomatous visual field progression. To address these aims, existing data from glaucoma patients 1) enrolled in the National Eye Institute funded Diagnostic Innovations in Glaucoma Study (DIGS 1995-present) and African Descent and Glaucoma Evaluation Study (ADAGES 2009-2021), and 2) managed at the UCSD Viterbi Family Department of Ophthalmology will be used in the AI model development and testing. We will also leverage UCSD's existing cloud-based AI pipeline to build a glaucoma-specific platform to train, test and in the future, update the deep learning models developed. In the future, this infrastructure can be used to support randomized clinical trial testing of AI guided glaucoma management and enable real-time decision support for clinicians.