The Role of ERBB4 in Atrial Electrophysiology and Atrial Fibrillation
ERBB4 在心房电生理学和心房颤动中的作用
基本信息
- 批准号:10503131
- 负责人:
- 金额:$ 42.38万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-01 至 2026-07-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdultAgingAlpha RhythmArrhythmiaAtrial FibrillationBiological ModelsCalciumCandidate Disease GeneCardiacCardiac Electrophysiologic TechniquesCardiac MyocytesCardiac developmentCardiovascular systemCause of DeathCell LineDataDefectDependenceDevelopmentDiseaseDown-RegulationERBB2 geneETV1 geneElectrophysiology (science)EnvironmentErbB4 Receptor Protein Tyrosine KinaseErbB4 geneEvaluationFunctional disorderGene DosageGenesGenetic TranscriptionHeartHeart AbnormalitiesHeart AtriumHeart DiseasesHeart failureHistologicHumanHypertensionIon ChannelKnockout MiceKnowledgeLeftLeft atrial structureLinkMAPK3 geneMaintenanceMedicalModelingMolecularMorbidity - disease rateMusMuscle CellsMutant Strains MiceMyocardiumNeuregulin 1Neuregulin ReceptorNodalOpticsPathogenesisPathway interactionsPatientsPhysiologicalPhysiologyPredispositionPrevalenceProcessPublic HealthReceptor Protein-Tyrosine KinasesResearchRiskRoleSignal PathwaySignal TransductionSodiumStrokeStructureSusceptibility GeneSystemTamoxifenTherapeuticTranscriptional ActivationTransgenic MiceTretinoinacquired factorbasecalmodulin-dependent protein kinase IIdefined contributioneffective therapygene regulatory networkgenetic risk factorgenome wide association studyheart rhythmhospital utilizationmortalitymouse modelpostnatalprogramsside effectstroke incidencesuccesstargeted treatmenttherapeutic targettranscription factortranscriptometranscriptomics
项目摘要
PROJECT SUMMARY
Atrial fibrillation (AF) is the leading cause of stroke and a major cause of morbidity and mortality in the US. AF is
due to both inherited and acquired factors. Genome-wide association studies have identified ERBB4 as a
candidate susceptibility gene for AF. Acquired conditions, such as aging, hypertension, and heart failure, are
known to cause electrical and structural changes in the left atrium (LA) in a process known as remodeling that
predisposes to AF. Our data show that left atrial ERBB4 levels are reduced in patients with AF. We have also
shown that ErbB4 is downregulated in heart disease mouse models. To study the role of ErbB4 in both atrial
electrical development and in acquired AF mechanisms, we have generated mouse models that have reduced
ErbB4 expression during development or acquired during adulthood. Both model systems show an important
dependency of correct ErbB4 gene dosage in the maintenance of normal atrial electrophysiology.
项目概要
心房颤动 (AF) 是中风的主要原因,也是美国发病和死亡的主要原因。自动对焦是
due to both inherited and acquired factors.全基因组关联研究已确定 ERBB4 是
candidate susceptibility gene for AF.后天性疾病,如衰老、高血压和心力衰竭,
已知会在称为重塑的过程中引起左心房 (LA) 的电气和结构变化
易患 AF。我们的数据显示 AF 患者左心房 ERBB4 水平降低。我们还有
表明 ErbB4 在心脏病小鼠模型中下调。 To study the role of ErbB4 in both atrial
电气发育和获得性 AF 机制中,我们生成了小鼠模型,这些模型减少了
ErbB4 在发育期间表达或在成年期间获得。 Both model systems show an important
正确的 ErbB4 基因剂量在维持正常心房电生理学中的依赖性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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David S Park其他文献
Ablation in Atrial Fibrillation with Ventricular Pacing Results in Similar Spatial Catheter Stability as Compared to Ablation in Sinus Rhythm with Atrial Pacing.
与心房起搏窦性心律消融相比,心室起搏房颤消融具有相似的空间导管稳定性。
- DOI:
10.4022/jafib.2373 - 发表时间:
2020 - 期刊:
- 影响因子:0
- 作者:
Matthew Dai;Chirag R. Barbhaiya;A. Aizer;Jonathan Hyde;Edward V. Kogan;Douglas S. Holmes;S. Bernstein;Michael A. Spinelli;David S Park;Larry A Chinitz;Lior Jankelson - 通讯作者:
Lior Jankelson
David S Park的其他文献
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{{ truncateString('David S Park', 18)}}的其他基金
The Role of ERBB4 in Atrial Electrophysiology and Atrial Fibrillation
ERBB4 在心房电生理学和心房颤动中的作用
- 批准号:
10671524 - 财政年份:2022
- 资助金额:
$ 42.38万 - 项目类别:
Etv1 is an Essential Regulator of Fast Conduction Tissues in the Heart
Etv1 是心脏快速传导组织的重要调节器
- 批准号:
9893031 - 财政年份:2017
- 资助金额:
$ 42.38万 - 项目类别:
Etv1 is an Essential Regulator of Fast Conduction Tissues in the Heart
Etv1 是心脏快速传导组织的重要调节器
- 批准号:
9311687 - 财政年份:2017
- 资助金额:
$ 42.38万 - 项目类别:
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