Northern New England Clinical and Translational Research Network

新英格兰北部临床和翻译研究网络(NNE-CTR)的长期目标， 由MaineHealth，佛蒙特州大学和南缅因州大学组成，将维持一项 临床和转化性研究基础设施，支持改善北部地区的社区卫生 新英格兰居民。缅因州和佛蒙特州拥有美国最老龄化的人口，再加上 乡村，使居民容易患上一系列疾病，从癌症到药物使用障碍，食物 不安全、肥胖、糖尿病和心血管疾病。此外，新英格兰北部有越来越多的 服务不足的移民人口以及美洲原住民人口。我们的社区一直是 受到新冠肺炎大流行的挑战，我们正在通过将初级保健与 与学术中心建立实践中心，开发以社区为基础的研究的创新方法。 在我们的头四年里，NNE-CTR为临床研究奠定了坚实的基础。我们的合作伙伴 最古老的以实践为基础的区域研究网络(PBRN)，达特茅斯合作组织，并得到积极支持 成功的NIH计划申请，包括两个Cobres，两个NCI计划赠款，一笔基础设施赠款 一个新的生物医学共享资源中心，以及一笔HRSA赠款，以建立阿片类药物治疗模式 在佛蒙特州首创。NNE-CTR PI在协调全国CTR网络方面发挥领导作用， 包括CTR国家冠状病毒队列合作(N3C)，这是一个在新冠肺炎上共享临床数据的注册机构 全国范围内，以及由美国国立卫生研究院赞助的RECOVER试验，这将定义新冠肺炎的长期后遗症。在……里面 此次续约，我们计划扩大我们在地区和全国的合作，加强我们的PBRN，以及 拥抱文化多样性。我们将加强核心资源，包括：生物统计学、流行病学和 研究设计核心，将提高数据能力和研究导航服务；专业 发展核心，将提供一系列新的教育和指导机会；试点 项目计划，该计划将提供新的灵活的资金机制，为 以社区为基础的项目；翻译研究和技术核心，提供最先进的 新调查员的技术和培训，以及社区参与和外联核心，其中 将建造更坚固的桥梁，通向服务不足的社区。我们提出了三个具体目标：1-扩大 基础设施和资源，以满足新英格兰北部的临床和转译研究需求；2- 加强临床和转化性研究，以解决卫生公平和在以下方面遇到的差距- 风险人群，包括扩大临床试验准入、远程医疗和指导培训计划 新的调查员；以及3--加快信息和通信技术网络内的区域和国家合作倡议 并通过NIH，如N3C和Recover。总而言之，我们将通过不断加强NNE-CTR 在多样性、包容性和公平性原则的支持下学习和改进。

The long-term goal of the Northern New England Clinical and Translational Research Network (NNE-CTR), composed of MaineHealth, the University of Vermont, and the University of Southern Maine, is to sustain a clinical and translational research infrastructure that supports improvements in community health for northern New England inhabitants. Maine and Vermont have the oldest populations in the U.S. and that, coupled with rurality, predisposes residents to a range of disorders ranging from cancer to substance use disorders, food insecurity, obesity, diabetes and cardiovascular disease. In addition, northern New England has a growing underserved immigrant population, as well as a Native American population. Our communities have been challenged by the Covid-19 pandemic, and we are addressing these challenges by linking primary care practice centers with academic centers and developing innovative approaches to community-based research. During our first four years, the NNE-CTR has built a strong foundation for clinical research. We partnered with the oldest regional practice-based research network (PBRN), the Dartmouth Co-Op, and actively supported successful NIH program applications, including two COBREs, two NCI program grants, an infrastructure grant for a new Center for Biomedical Shared Resources, and a HRSA grant to build on the opioid treatment model pioneered in Vermont. The NNE-CTR PI is playing a leadership role in coordinating a national CTR network, including the CTR National COVID Cohort Collaborative (N3C), a registry to share clinical data on Covid-19 nationally, and the NIH-sponsored RECOVER trial, which will define the long-term sequelae of Covid-19. In this renewal, we plan to expand our collaborations both regionally and nationally, strengthen our PBRN, and embrace cultural diversity. We will strengthen Core resources that include: the Biostatistics, Epidemiology and Research Design Core, which will improve data capability and research navigation services; the Professional Development Core, which will offer an array of new educational and mentorship opportunities; the Pilot Projects Program, which will provide new and flexible funding mechanisms to offer more support for community-based projects; the Translational Research and Technology Core, offering state-of-the-art technologies and training for new investigators, and the Community Engagement and Outreach Core, which will build stronger bridges to underserved communities. We propose three specific aims: 1-Expand infrastructure and resources to address clinical and translational research needs in northern New England; 2- Strengthen clinical and translational research that addresses health equity and disparities encountered by at- risk populations, including expansion of clinical trial access, telehealth, and mentored training programs for new investigators; and 3-Accelerate regional and national collaborative initiatives within the IDeA networks and through NIH such as N3C and RECOVER. In sum, we will strengthen the NNE-CTR through continuous learning and improvement supported by the principles of diversity, inclusion, and equity.