Coordinating Center for the Program on the Origins of Gastroesophageal Cancers

哥伦比亚协调中心（CCC）将提供必要的领导、基础设施和监督， 支持并实现NCI胃食管癌起源计划（PGEC）的总体目标 以及六个跨学科的R 01项目。PGEC的使命是推广最近的调查结果， 胃食管癌的分子分类和基因组学，检查和定义这些癌症如何 最初在细胞水平上发展，并比较和对比的贡献和潜在的机制， 肿瘤起始细胞的风险和进展。协调、沟通和接触不足将造成 项目成功的重大障碍。 协调委员会将提供领导和组织结构，以促进和加强相互协作 通过培训、会议和工作组。CCC将制定标准化和协调 数据元素（例如，正确跟踪细胞来源），实现技术解决方案， 挑战，共享模型和资源，并推进尖端技术的使用。CCC将 促进公平和公正（采用可查找性、可访问性、互操作性和可重用性原则） 获得体内和体外模型，提供关于研究目标的真实的时间反馈，并允许进行评估 严谨和可复制的。中央协调委员会将为早期调查人员提供培训和支持， 从事跨学科研究，培养下一代科学家。 我们的CCC和科学咨询委员会汇集了多学科科学家， 以及多样化的研究、临床、数据库和联盟经验来支持这些目标。这个研究小组在 与哥伦比亚大学欧文医学中心（CUIMC）的许多机构资源相结合， 纽约基因组中心（NYGC）将是项目成功的关键资产。 具体目标1：提供强有力的愿景和科学领导，以确保PGEC符合其 方案目标。次级目标1A-初级调查员的培训和发展;以及次级目标1B- 监测研究进展并提供可操作的真实的时间反馈。 具体目标2：为PGEC提供行政监督和结构。 具体目标3：协调和组织各种会议。 具体目标4：为项目构建和维护数据共享和门户。 影响：CCC将提供强有力的领导，拥有一支经验丰富的多学科团队， 所有PGEC活动的组织结构，以促进资源共享，提高生产力， 合作，并最终影响到更好地了解和预防GE癌症发病率和死亡率。进一步 与其他长期资源和培训方案的整合是额外的重要交付成果。

The Columbia Coordinating Center (CCC) will provide the necessary leadership, infrastructure, and oversight to support and fulfill the overarching goals of NCI’s Program on the Origins of Gastroesophageal Cancers (PGEC) and the six transdisciplinary R01 projects. The mission of the PGEC is to extend recent findings regarding molecular classifications and genomics of gastroesophageal cancers, examine and define how these cancers initially evolve at the cellular level, and compare and contrast the contributions and underlying mechanisms of tumor-initiating cells to risk and progression. Inadequate coordination, communication and access will create significant barriers to program success. The CCC will provide the leadership and organizational structure to facilitate and strengthen cross collaboration through trainings, meetings and working groups. The CCC will develop standardization and harmonization of data elements (e.g., track the cell of origin correctly) across research projects, enable the resolution of technical challenges, share models and resources, and advance the use of cutting-edge technologies. The CCC will facilitate equitable and FAIR (employing principles of findability, accessibility, interoperability, and reusability) access to in vivo and in vitro models, provide real time feedback on research objectives and allow for assessment of rigor and reproducibly. The CCC will provide training and support for early-stage investigators to conduct pilot work and engage in transdisciplinary research to build the next generation of scientists. Our CCC and the assembled Scientific Advisory Board brings together multidisciplinary scientists with necessary and diverse research, clinical, database and consortia experience to support these aims. This research team in conjunction with the many institutional resources at Columbia University Irving Medical Center (CUIMC) and New York Genome Center (NYGC) will be pivotal assets to program success. Specific Aim 1: Provide strong vision and scientific leadership to ensure the PGEC meets its programmatic goals. Sub-Aim 1A- training and development of junior investigators; and Sub-Aim 1B- monitoring research progress and to provide real time feedback that are actionable. Specific Aim 2: Provide administrative oversight and structure for the PGEC. Specific Aim 3: Coordinate and organize meetings and conferences. Specific Aim 4: Build and maintain a data commons and portal for the program. Impact: The CCC will provide strong leadership with an experienced and multidisciplinary team and an organizational structure for all PGEC activities to facilitate resource sharing that will expedite productivity, collaboration, and ultimately impact to better understand and prevent GE cancer morbidity and mortality. Further integration with other long-standing resources and training programs are additional important deliverables.