Pre-cancer atlases of cutaneous and hematologic origin (PATCH Center)

皮肤和血液来源的癌前图谱（PATCH 中心）

• 批准号: 10818803
• 负责人: PETER Karl SORGER
• 金额: $ 75.74万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-04 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10818803
• 关键词: 3-Dimensional; Atlases; Cells; Clinical; Clinical Data; Communication; Complex; Computer software; Cutaneous; Data; Data Analyses; Data Element; Diagnosis; Disease; Ensure; Genetic; Goals; Hematology; Histopathology; Human; Image; Malignant Neoplasms; Metadata; Methods; Molecular; Participant; Patients; Process; Publications; Sampling; Tissue Microarray; Visualization software; Work; data dissemination; data portal; data sharing; data submission; follow-up; improved; melanoma; member; multiplexed imaging; open data; premalignant; prevent; process optimization; progression risk; quality assurance; skin lesion; software development; three-dimensional visualization; tool; transcriptomics

ABSTRACT The overall aims of the Center for Pre-cancer Atlases of Cutaneous and Hematologic Origin (PATCH Center) will pivot in the supplemental year to focus on data analysis and dissemination. The Administration and Project Management team will focus on the scientific management of the Center, communicate with NCI staff and HTAN Centers, and ensure regular data deposition. They will guide the other Center members to focus on all activities related to the completion and dissemination of the Center atlas. We anticipate the biospecimen and clinical teams will focus on curating clinical and biospecimen metadata and participating in the interpretation of results for publication and other dissemination activities. Most characterization activities for the atlas and the SARDANA TNP will be completed prior to the initiation of the supplement, but additional characterization will be performed for quality assurance and follow up experimentation during the publication process. The bulk of the activities will be in data analysis, software development, and dissemination of complex image data. The Center will be working on 3D segmentation and visualization tools, improvements to the MCMICRO pipeline, and advancements to Minerva Story tools to accommodate 3D visualization as well as clinical and biospecimen metadata. Our Center will continue to work with the DCC to develop and optimize the process for sharing highly complex imaging data.

摘要 皮肤和血液起源癌前病变中心（PATCH）的总体目标是 中心）将在补充年度重点关注数据分析和传播。政府当局 和项目管理团队将专注于中心的科学管理，与 NCI员工和HTAN中心，并确保定期的数据存储。他们将指导其他中心 委员会成员应集中精力开展与完成和传播中心地图集有关的所有活动。我们 预计生物标本和临床团队将专注于管理临床和生物标本元数据， 参与对结果的解释，以供出版和其他传播活动。最 图谱和SARDANA TNP的表征活动将在 补充，但将进行额外表征，以保证质量并进行随访 在出版过程中进行实验。大部分活动将在数据分析，软件， 开发和传播复杂的图像数据。该中心将致力于3D分割 和可视化工具，MCMICRO管道的改进，以及Minerva Story的改进 用于容纳3D可视化以及临床和生物样本元数据的工具。我中心将 继续与DCC合作，开发和优化共享高度复杂成像的流程 数据

项目成果

Stitching and registering highly multiplexed whole-slide images of tissues and tumors using ASHLAR.

• DOI: 10.1093/bioinformatics/btac544
• 发表时间: 2022-09-30
• 期刊: Bioinformatics (Oxford, England)

Sequential apoptotic and multiplexed proteomic evaluation of single cancer cells.

• DOI: 10.1126/sciadv.adg4128
• 发表时间: 2023-06-23
• 期刊: SCIENCE ADVANCES
• 影响因子: 13.6
• 作者: Lecky, Emmalyn;Mukherji, Atreyi;German, Rebecca;Antonellis, Gabriella;Lin, Jia-Ren;Yorsz, Michael;McQueeney, Kelley E.;Ryan, Jeremy;Ng, Kimmie;Sicinska, Ewa;Sorger, Peter K.;Letai, Anthony;Bhola, Patrick D.
• 通讯作者: Bhola, Patrick D.