Pre-cancer atlases of cutaneous and hematologic origin (PATCH Center)

皮肤和血液来源的癌前图谱（PATCH 中心）

• 批准号: 10818803
• 负责人: PETER Karl SORGER
• 金额: $ 75.74万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-04 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10818803
• 关键词: 3-Dimensional; Atlases; Cells; Clinical; Clinical Data; Communication; Complex; Computer software; Cutaneous; Data; Data Analyses; Data Element; Diagnosis; Disease; Ensure; Genetic; Goals; Hematology; Histopathology; Human; Image; Malignant Neoplasms; Metadata; Methods; Molecular; Participant; Patients; Process; Publications; Sampling; Tissue Microarray; Visualization software; Work; data dissemination; data portal; data sharing; data submission; follow-up; improved; melanoma; member; multiplexed imaging; open data; premalignant; prevent; process optimization; progression risk; quality assurance; skin lesion; software development; three-dimensional visualization; tool; transcriptomics

ABSTRACT The overall aims of the Center for Pre-cancer Atlases of Cutaneous and Hematologic Origin (PATCH Center) will pivot in the supplemental year to focus on data analysis and dissemination. The Administration and Project Management team will focus on the scientific management of the Center, communicate with NCI staff and HTAN Centers, and ensure regular data deposition. They will guide the other Center members to focus on all activities related to the completion and dissemination of the Center atlas. We anticipate the biospecimen and clinical teams will focus on curating clinical and biospecimen metadata and participating in the interpretation of results for publication and other dissemination activities. Most characterization activities for the atlas and the SARDANA TNP will be completed prior to the initiation of the supplement, but additional characterization will be performed for quality assurance and follow up experimentation during the publication process. The bulk of the activities will be in data analysis, software development, and dissemination of complex image data. The Center will be working on 3D segmentation and visualization tools, improvements to the MCMICRO pipeline, and advancements to Minerva Story tools to accommodate 3D visualization as well as clinical and biospecimen metadata. Our Center will continue to work with the DCC to develop and optimize the process for sharing highly complex imaging data.

抽象的 皮肤和血液学起源前癌前地图中心的总体目标（斑块 中心）将在补充一年中枢纽，以专注于数据分析和传播。政府 项目管理团队将专注于该中心的科学管理，与 NCI员工和HTAN中心，并确保定期数据沉积。他们将引导另一个中心 成员专注于与中心地图集的完成和传播有关的所有活动。我们 预期生物晶体和临床团队将专注于策划临床和生物测量元数据以及 参与对出版和其他传播活动结果的解释。最多 在启动之前，将完成Atlas和Sardana TNP的表征活动 补充剂，但将进行额外的特征以进行质量保证和跟进 在出版过程中进行的实验。大部分活动将用于数据分析，软件 复杂图像数据的开发和传播。该中心将进行3D细分 和可视化工具，改进麦克米罗管道以及密涅瓦故事的进步 适应3D可视化以及临床和生物测试元数据的工具。我们的中心愿意 继续与DCC合作开发和优化共享高度复杂成像的过程 数据。

项目成果

Stitching and registering highly multiplexed whole-slide images of tissues and tumors using ASHLAR.

• DOI: 10.1093/bioinformatics/btac544
• 发表时间: 2022-09-30
• 期刊: Bioinformatics (Oxford, England)

Sequential apoptotic and multiplexed proteomic evaluation of single cancer cells.

• DOI: 10.1126/sciadv.adg4128
• 发表时间: 2023-06-23
• 期刊: SCIENCE ADVANCES
• 影响因子: 13.6
• 作者: Lecky, Emmalyn;Mukherji, Atreyi;German, Rebecca;Antonellis, Gabriella;Lin, Jia-Ren;Yorsz, Michael;McQueeney, Kelley E.;Ryan, Jeremy;Ng, Kimmie;Sicinska, Ewa;Sorger, Peter K.;Letai, Anthony;Bhola, Patrick D.
• 通讯作者: Bhola, Patrick D.