The Computational Tumor Immunology Core (CTIC)

计算肿瘤免疫学核心 (CTIC)

• 批准号: 10505677
• 负责人: Derin B Keskin
• 金额: $ 25.99万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10505677
• 关键词: Area; Atlases; Award; Cancer Patient; Cells; Clinical; Clonal Evolution; Collaborations; Data; Data Analyses; Epitopes; Genomics; Hereditary Nonpolyposis Colorectal Neoplasms; Immune; Immunoprevention; Intercept; Lead; Lung; Malignant Neoplasms; Malignant neoplasm of lung; Mutation; Mutation Analysis; Nodule; Patients; Premalignant Neoplasm; Proteomics; RNA; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Role; Science; Services; The Cancer Genome Atlas; Tumor Antigens; Vaccines; Validation; cancer genetics; computerized tools; experience; genomic data; immunogenicity; improved; innovation; insertion/deletion mutation; neoantigens; new technology; novel; programs; success; tool; tumor; tumor immunology; vaccine immunogenicity; working group

CTIC Core: Project Summary/Abstract The Computational Tumor Immunology Core (CTIC) will provide CAP-IT CRI researchers with state-of-the-art computational genomic, tumor immunology, immunopeptidomic, and spatial genomic services to support research projects for immunoprevention of patients with a. Lynch syndrome (LS; Project 1), b. lung cancer non- solid nodule (NSN), pre-malignant neoplasms (Project 2), and c. any new CAP-IT projects that are subsequently approved by the CAP-IT program. CTIC investigators include accomplished leaders in computational cancer genetics, tumor immunology, single-cell profiling, and spatial genomics. We have significant experience with all proposed analyses to be performed. As the CTIC areas of focus are dynamic and rapidly evolving, we anticipate incorporating new technologies and computational strategies as they develop to help drive Projects 1 and 2. The CTIC will successfully delineate LNP RNA immunoprevention and immune interception vaccines for LS and NSN patients and provide necessary shared resources for the CAP-IT, network-wide.

CTIC Core：项目概要/摘要 计算肿瘤免疫学核心（CTIC）将为CAP-IT CRI研究人员提供最先进的 计算基因组学、肿瘤免疫学、免疫肽组学和空间基因组学服务， 免疫预防a. Lynch综合征（LS;项目1），B。非肺癌 实性结节（NSN），癌前病变（项目2），和c.任何新的CAP-IT项目， 由CAP-IT计划批准。CTIC研究人员包括计算癌症领域的杰出领导者 遗传学、肿瘤免疫学、单细胞分析和空间基因组学。我们在所有方面都拥有丰富的经验 拟进行的分析。由于CTIC的重点领域是动态的，并且正在迅速发展，我们预计 随着新技术和计算策略的发展，它们将有助于推动项目1和项目2。的 CTIC将成功描述LS和NSN的LNP RNA免疫预防和免疫拦截疫苗 患者，并为CAP-IT提供必要的共享资源，网络范围。