Using Decision Making Science to Optimize Deceased Donor Kidney Allocation

利用决策科学来优化已故捐赠者肾脏的分配

基本信息

  • 批准号:
    10507025
  • 负责人:
  • 金额:
    $ 16.55万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-08-01 至 2026-04-30
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY/ABSTRACT Although kidney transplantation provides better survival, quality of life, and long-term cost compared to maintenance dialysis, the majority of patients with end-stage kidney disease in the United States will never receive a transplant due to a severe shortage of donated kidneys. In response to this shortage, there has been an increasing emphasis on expanding the use of less-than-ideal deceased donor kidneys, which still provide survival and quality of life benefits over extended waiting time for a higher quality kidney. Despite efforts to increase the aggressiveness of organ recovery and utilization, thousands of likely transplantable kidneys are not recovered or discarded after recovery each year, primarily due to quality concerns. We and others have shown that clinicians’ subjective assessments of organ quality are often too conservative, and that cognitive heuristics impact perception or organ quality and likelihood of organ utilization. A key target for improving perceptions of organ quality is therefore to use decision science to improve the presentation of information during organ offers. The goal of the proposed project is to understand how surgeons prioritize and consume information during organ offer decisions, then use a mechanisms-based approach to target cognitive heuristics that favor inappropriate organ offer refusal. We will begin with improving the presentation of the results of procurement biopsies. Despite reliance on findings from these biopsies— which are the most common reason for deceased donor kidney discard— their independent prognostic capability is limited as they are currently performed. We hypothesize that our approach will enable standardization of procurement biopsy presentation in a manner that reduces deleterious impacts on organ offer acceptance. To complete the proposed project and acquire the skills needed for development into an independent investigator in the field of kidney transplantation, Dr. Husain will work closely with a multidisciplinary team of mentors and advisors, led by Dr. Sumit Mohan, to develop research expertise in the areas of interventional and prospective study design, decision making science & human-centered design, kidney transplant epidemiology, and research dissemination & professional development. Upon completion of this project, he will have the scientific and research expertise needed to be a grant-supported independent investigator in this field.
项目总结/摘要 虽然肾移植提供了更好的生存,生活质量和长期成本相比, 维持性透析,大多数终末期肾病患者在美国将永远不会 由于捐赠肾脏严重短缺而接受移植。为了应对这种短缺, 越来越多的人强调扩大使用不太理想的死者捐赠肾脏, 延长等待更高质量肾脏的时间有利于生存和生活质量。尽管努力 增加器官恢复和利用的积极性,但数千个可能可移植的肾脏却没有 每年回收或丢弃,主要是由于质量问题。我们和其他人已经证明 临床医生对器官质量的主观评估往往过于保守, 影响感知或器官质量和器官利用可能性。改善对环境的认识的一个关键目标是 因此,器官质量是利用决策科学来改善器官提供过程中的信息呈现。 拟议项目的目标是了解外科医生如何在器官移植过程中优先考虑和消费信息。 提供决策,然后使用基于机制的方法来瞄准有利于不适当的认知策略, 拒绝器官捐赠我们将开始改进采购活组织检查结果的表述。尽管 依赖于这些活检的结果-这是死亡供体肾脏的最常见原因 丢弃-它们的独立预后能力是有限的,因为它们目前被执行。我们假设 我们的方法将使采购活检展示标准化, 对接受器官捐献的有害影响。 完成拟议的项目,并获得发展成为独立调查员所需的技能 在肾移植领域,Husain博士将与多学科导师团队密切合作, 由Sumit Mohan博士领导的顾问,在干预和前瞻性领域发展研究专业知识 研究设计、决策科学和以人为本的设计、肾移植流行病学和研究 传播和专业发展。在这个项目完成后,他将有科学和 研究专门知识需要成为这一领域的赠款支持的独立调查员。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Syed Ali Husain其他文献

Allocation biopsies of deceased donor kidneys: a necessary tool to expand the donor pool
已故捐赠者肾脏分配活检:扩大捐赠者库的必要手段
  • DOI:
    10.1016/j.kint.2024.09.014
  • 发表时间:
    2024-12-01
  • 期刊:
  • 影响因子:
    12.600
  • 作者:
    Syed Ali Husain;Sumit Mohan
  • 通讯作者:
    Sumit Mohan
Patient and Provider Attitudes Toward Patient-Facing Kidney Organ Offer Reporting
患者和提供者对面向患者的肾脏器官捐赠报告的态度
  • DOI:
    10.1016/j.ekir.2025.01.013
  • 发表时间:
    2025-04-01
  • 期刊:
  • 影响因子:
    5.700
  • 作者:
    Syed Ali Husain;Jordan A. Rubenstein;Seshma Ramsawak;Anne M. Huml;Miko E. Yu;Lindsey M. Maclay;Jesse D. Schold;Sumit Mohan
  • 通讯作者:
    Sumit Mohan
Discrepant creatinine- versus cystatin C-based kidney function estimates in pediatric heart and liver transplant recipients
  • DOI:
    10.1007/s00467-024-06358-w
  • 发表时间:
    2024-04-01
  • 期刊:
  • 影响因子:
    2.600
  • 作者:
    Amy R. Lipman;Syed Ali Husain
  • 通讯作者:
    Syed Ali Husain

Syed Ali Husain的其他文献

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{{ truncateString('Syed Ali Husain', 18)}}的其他基金

Using Decision Making Science to Optimize Deceased Donor Kidney Allocation
利用决策科学来优化已故捐赠者肾脏的分配
  • 批准号:
    10669248
  • 财政年份:
    2022
  • 资助金额:
    $ 16.55万
  • 项目类别:

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    面上项目

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