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NMR Core

NMR Core
核磁共振核心
批准号：
10506950
负责人：
ANGELA M. GRONENBORN
金额：
$96.87万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
项目状态：
未结题
起止时间：
2022-07-01 至 2027-04-30
来源：
https://reporter.nih.gov/project-details/10506950
关键词：
CapsidCell NucleusCellsCommunitiesComplexData AnalysesDetectionDiseaseEnvironmentEquipmentFluorineFrequenciesFutureGoalsHIVHIV-1InstitutionIntegraseIntegrase InhibitorsIntegration Host FactorsMagicMeasurementMeasuresMethodologyMethodsMolecular ConformationNMR SpectroscopyNatureNuclearNuclear ImportPhysiologicalPositioning AttributeProteinsProtocols documentationRecombinant ProteinsResearchResearch PersonnelResolutionResourcesSavingsSiteSpin LabelsStructureTechnologyTimeWorkbasebiophysical propertiescell typedata acquisitiondesignexperimental studyin vivoinhibitorinnovationinsightinstrumentationmagnetic fieldnew technologyprotein complexprotein structurescreeningsolid statesolid state nuclear magnetic resonancestructural biologytrafficking

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中文摘要
翻译
核磁共振芯 核磁共振核心的总体目标是为PCHPI研究人员提供最先进的能力，用于原子- HIV-1蛋白及其复合体结构和动力学的水平表征。为了实现这一目标， 我们将利用精湛的仪器资源、创新的实验方案和独特的 在过去十年中形成了专门知识。具体目标是：i)支持PCHPI项目和额外的- 中心合作者通过为HIV-1研究提供尖端的固态核磁共振功能，以及ii)开发 用于HIV-1研究的细胞内溶液和固态~(19)F核磁共振。核磁共振核心开发的新技术 将对HIV-1细胞结构生物学产生重大影响。
英文摘要
NMR Core The overall goal of the NMR Core is to provide state-of-the art capabilities for PCHPI researchers, for atomic- level characterization of structure and dynamics of HIV-1 proteins and their complexes. To accomplish this goal, we will take advantage of superb instrumentation resources, innovative experimental protocols, and unique expertise developed during the past decade. Specific aims are designed to i) support PCHPI projects and extra- center collaborators by providing cutting-edge solid-state NMR capabilities for HIV-1 research, and ii) develop in-cell solution and solid state 19F NMR for HIV-1 research. The novel technologies developed by the NMR Core will have major impact on HIV-1 cellular structural biology.
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Molecular, Cellular and Behavioral Impact of the R203W PACS1 Syndrome Mutation
Administrative Core
Pittsburgh Center for HIV Protein Interactions (PCHPI)
Pittsburgh Center for HIV Protein Interactions (PCHPI)
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