Administrative Core

行政核心主任：Angela M. Gronenborn博士将主要负责指导和激励拟议的PCHPI的研究和项目。Gronenborn博士在过去的30年里领导了研究小组，首先在英国伦敦的MRC，然后在德国慕尼黑的马克斯-普朗克生物化学研究所，从1988年到2006年，在贝塞斯达的美国国立卫生研究院。她负责监督技术人员、学生、博士后和长期科研人员的工作。她将指导核心之间以及核心与研究项目之间（内部和外部）合作框架的实施。此外。Gronenborn博士将出席NIGMS指定的网络咨询委员会年会和年度科学会议。Gronenborn博士将准备PCHPI合作计划的年度更新（由执行委员会指导），并将其提供给咨询委员会。此外，主任和中心协调员将主要负责确保中心各方面的顺利运作。Gronenborn博士将担任执行委员会主席。中心协调员：Teresa Brosenitsch博士将担任中心协调员。自PCHPI成立以来，Brosenitsch博士一直是该中心的一员，并将继续监督中心的日常运作以及成员和合作者之间的沟通。在格罗恩伯恩医生行政助理的帮助下。Brosenitsch博士将确保会议、电话会议和教育计划如期进行，并将监督研讨会和研讨会的后勤工作，包括差旅安排。Brosenitsch博士还将协调所有的教育和合作促进活动，包括合作发展计划的征求、申请和审查过程。Brosenitsch博士直接向Gronenborn博士报告，并将监督执行委员会指令和政策的实施和协调。她将成为执行委员会的成员。主任和中心协调员将定期安排每两周举行一次会议。Brosenitsch博士将与结构生物学系的工作人员密切合作，包括行政助理、业务经理和IT人员，以开展核心的活动。执行委员会：执行委员会由中心主任、中心协调员、各核心主任、各项目负责人组成。它将每月召开一次会议，确定研究重点，制定如何克服技术问题和瓶颈的战略，分析中心的进展和对项目时间表的遵守情况，监督PCHPI的财务状况，建立和实施教育和培训计划，监督PCHPI的网络服务器内容，并制定如何促进合作的战略。科学顾问委员会（SAB）：将与NIGMS协商并经其批准后任命科学顾问委员会。SAB将有至少三名外部顾问，包括一名病毒学家和一名结构生物学家，由执行委员会通过提名和投票任命。SAB将每年召开一次会议，审查中心在里程碑方面的进展（如第1节方法所述），为定义新的结构目标提供方向，并讨论改善进展的策略。审计委员会的咨询意见将对有关项目继续或停止的决定发挥重要作用（见下文）。评议委员会将被要求在他们访问后的一个月内提供一份书面评论摘要。该评论和PCHPI的回应将提供给NIGMS项目官员。NIGMS项目官员将被邀请参加PCHPI SAB的所有会议。顾问：Ronald Montelaro博士，在PCHPI资助的头五年，PCHPI的联合主任将作为行政事务顾问，运用他在艾滋病毒- 1领域的广泛知识和经验，帮助确定研究和合作重点。

The Administrative Core Director: Angela M. Gronenborn, PhD will have the primary responsibility for directing and exciting the research and programs of the proposed PCHPI. Dr. Gronenborn has directed research groups for the last 30 years, first at the MRC in London, UK, then at the Max-Planck-institute for Biochemistry in Munich, Germany, and, from 1988-2006, at the NIH in Bethesda. She has overseen the work of technical personnel, students, post-docs and permanent scientific staff. She will direct the implementation of the collaborative framework among the cores and between the cores and research projects (both in-house and external). In addition. Dr. Gronenborn will attend the annual meetings of the NIGMS appointed network advisory committee and the annual scientific meeting. Dr. Gronenborn will prepare annual updates to the PCHPI's plans for collaboration (guided by the Executive Committee) and provide these to the Advisory Committee. In addition, the Director along with the Center Coordinator will have the primary responsibility for ensuring that all aspects of the center function smoothly. Dr. Gronenborn will chair the Executive Committee. Center Coordinator: Teresa Brosenitsch, PhD will serve as the Center Coordinator. Dr. Brosenitsch has been a part of the PCHPI since its inception and will continue to oversee the day-to-day operation of the center and communication among members and collaborators. With help from Dr. Gronenborn's administrative assistant. Dr. Brosenitsch will ensure that meetings, teleconferences, and educational programs occur as outlined and will oversee the logistics for workshop and seminar implementation, including travel arrangements. Dr. Brosenitsch will also coordinate all educational and collaboration promotion activities, including the Collaboration Development Program solicitation, application, and review processes. Dr. Brosenitsch reports directly to Dr. Gronenborn and will oversee implementation and coordination of the directives and policies of the Executive Committee. She will be a member of the Executive Committee. The Director and the Center Coordinator will have regularly scheduled meetings on a bi-weekly basis. Dr. Brosenitsch will work closely with the staff of the Department of Structural Biology, including an administrative assistant, the business manager, and IT personnel, to carry out the activities of the core. Executive Committee: The Executive Committee will be composed of the Center Director, the Center Coordinator, each of the core directors, and the leaders of each of project. It will meet on a monthly schedule and will define research priorities, strategize as to how to overcome technical problems and bottlenecks, analyze center progress and adherence to project timelines, provide oversight of PCHPI finances, establish and implement educational and training programs, provide oversight of the PCHPIs' web server content, and strategize about how to promote collaboration. Scientific Advisory Board (SAB): A Scientific Advisory Board will be appointed in consultation with and subject to approval of the NIGMS. The SAB will have at least three external advisors, including a virologist and a structural biologist, to be appointed by the Executive Committee through nominations and voting. The SAB will meet annually to review the center's progress toward milestones (as outlined in the Section 1, Approach), provide direction for defining new structural targets, and discuss strategies to improve progress. The advice of the SAB will play an important role on decisions related to project continuation or cessation (see below). The SAB will be asked to provide a written summary of their critique within a month of their visit. This critique and the PCHPI's response will be provided to the NIGMS program official. The NIGMS program official will be invited to attend all meetings of the PCHPI SAB. Consultant: Dr. Ronald Montelaro, co-Director of the PCHPI during the first five years of PCHPI funding will serve as a consultant on administrative matters, applying his extensive knowledge and experience in the HIV-l field, to help set research and collaboration priorities.