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Investigating the Neural Basis of Flexible Emotion Perception

研究灵活情绪感知的神经基础

基本信息

批准号：
10569934
负责人：
Jonathan Bronner Freeman
金额：
$ 22.23万
依托单位：
COLUMBIA UNIV NEW YORK MORNINGSIDE
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-02-10 至 2023-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10569934
关键词：
Investigating Neural Basis Flexible Emotion

项目摘要

Project Summary/Abstract Accurate perception of others' emotion is critical for successful social interaction, yet it diminishes over the lifespan and is impaired across a wide range of disorders, including anxiety, depression, bipolar disorder, autism, and schizophrenia. The current proposal builds on a computational model developed by the PI, which posits that perceptions of social categories, including emotion categories, are driven not only by bottom-up cues inherent to targets (e.g., facial features) but also top-down factors harbored within perceivers, such as context and expectations. Although recent studies have documented the impact of such top-down factors in emotion perception, the mechanisms underlying these top-down impacts and how “deeply” they manifest at lower levels of visual representation is far less clear. The overarching goal of this proposal is to use cutting- edge neuroimaging and behavioral methods to understand basic mechanisms of facial emotion perception, and particularly the impact by expectations and context. Functional magnetic resonance imaging (fMRI) will be used in conjunction with an innovative behavioral technique developed by the PI to accomplish 3 specific aims: (a) examine how context and expectations systematically bias the visual representation of a face's emotion, which is driven by OFC‒FG interplay and depends on IFOF integrity; (b) test whether this top-down modulation is automatic and does not reflect some form of post-perceptual response bias; and (c) this mechanism this mechanism is shaped by inter-individual variability in emotion-conceptual knowledge, which provides a set of top-down expectations on the perception of facial emotion. The results will have numerous implications for the understanding of flexible emotion perception at the behavioral and neural levels, and will also help inform a variety of clinical processes involving the impairment of emotion perception and social dysfunction.

项目摘要/摘要对他人情绪的准确感知是成功社交的关键，但随着时间的推移，这种感知会逐渐减弱寿命长，患有多种疾病，包括焦虑、抑郁、双相情感障碍、自闭症和精神分裂症。目前的提议建立在PI开发的计算模型的基础上，该模型假设对社会类别的认知，包括情感类别，不仅是由自下而上驱动的目标固有的提示(例如，面部特征)，但也有隐藏在感知器中的自上而下的因素，例如背景和期望。尽管最近的研究记录了这种自上而下的因素在情绪感知，这些自上而下影响的机制，以及它们在较低级别的视觉表现远没有那么清晰。这项提案的首要目标是使用切割- 边缘神经成像和行为方法，以了解面部情绪感知的基本机制，尤其是预期和背景的影响。功能磁共振成像(FMRI)将是与PI开发的创新行为技术结合使用，以实现3个特定目标： (A)考察背景和期望如何系统性地偏向面部情绪的视觉表现，它由OFC-FG交互作用驱动，并取决于IFOF完整性；(B)测试这种自上而下的调制是自动的，并不反映某种形式的知觉后反应偏差；以及(C)这种机制机制是由情绪-概念知识的个体间差异性形成的，这提供了一套对面部情绪知觉的自上而下的期望。这一结果将对在行为和神经层面上理解灵活的情绪感知，也将有助于了解涉及情绪知觉障碍和社交功能障碍的各种临床过程。