The neural basis of touch and proprioreception in the primate orofacial sensorimotor cortex

灵长类口面部感觉运动皮层触觉和本体感受的神经基础

基本信息

  • 批准号:
    10543656
  • 负责人:
  • 金额:
    $ 54.38万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-12-23 至 2023-03-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY There is a fundamental gap in understanding the cortical representations and integration of tactile and proprio- ceptive sensations accompanying bodily movements in general and oromotor behavior in particular. This repre- sents an important problem because until it is understood, the mechanisms underlying orofacial pain, sensorimo- tor impairments, and sensorimotor integration will remain largely incomprehensible. The goal of the proposed research is to dissociate the cortical representations of touch and proprioception during natural feeding behavior by using an innovative sequence of nerve blocks together with multi-electrode array recordings and 3D tracking of tongue and jaw movements in non-human primates. The tongue is a unique structure for investigating this because it is in constant motion and assumes various postures when touching other oral structures (e.g., teeth, palate, and gingiva) during feeding. More importantly, the tactile and proprioceptive afferent fibers innervating the tongue enter the central nervous system separately in trigeminal (lingual nerve branch) and hypoglossal cranial nerves, respectively. Such unique anatomy enables experimental dissociation of touch and propriocep- tion. The central hypothesis is that tongue posture and contact with other oral structures are reflected in the proprioception- and tactile-related responses of neurons in the primary somatosensory (SIo) and primary motor (MIo) areas of the orofacial sensorimotor cortex (OSMcx). This hypothesis will be tested by pursuing three spe- cific aims: (1) determine how information about tongue posture and contact with other oral structures is encoded in MIo and SIo during natural feeding by eliminating tactile stimuli to the tongue and surrounding oral structures through sequential nerve blocks to the maxillary and mandibular sensory branches of the trigeminal nerve, (2) dissociate the neurons’ motor response from a proprioceptive response by using intracortical microstimulation (ICMS) to evoke muscle twitches while tactile inputs to the tongue and other oral structures are blocked, and (3) characterize the functional connectivity between tactile- and proprioceptive-related regions in OSMcx by spectral coherence analysis and by the effects of low-intensity ICMS of a tactile region on a proprioceptive one and vice versa. The proposed research uses an innovative approach that leverages the unique sensory innervation of the oral region by different cranial nerves and integrates the simultaneous neural recording and tracking of the tongue and jaw movements in 3D. The proposed research is significant because it will bridge the results of decades of research on cortical representation of oral somatosensation and on the biomechanics of tongue/jaw movements during oromotor behavior, thus filling an important gap in the field. The knowledge gained from this work will lay the groundwork for future studies on oral somatosensation, pain mechanisms, and sensorimotor integration. Ultimately such knowledge has the potential to inform the development of strategies for treatment of sensory impairments associated with dental implants, trigeminal neuralgia, temporomandibular disorders, orofa- cial pain, and for the restoration of sensory feedback for use in brain-machine interface.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Fritzie Arce-McShane其他文献

Fritzie Arce-McShane的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Fritzie Arce-McShane', 18)}}的其他基金

The neural basis of touch and proprioreception in the primate orofacial sensorimotor cortex
灵长类口面部感觉运动皮层触觉和本体感受的神经基础
  • 批准号:
    10359788
  • 财政年份:
    2021
  • 资助金额:
    $ 54.38万
  • 项目类别:
Disambiguating natural aging from Alzheimer's disease through changes in oral neuromechanics
通过改变口腔神经力学来消除自然衰老与阿尔茨海默病的关系
  • 批准号:
    10634762
  • 财政年份:
    2020
  • 资助金额:
    $ 54.38万
  • 项目类别:
Disambiguating natural aging from Alzheimer's disease through changes in oral neuromechanics
通过改变口腔神经力学来消除自然衰老与阿尔茨海默病的关系
  • 批准号:
    10256795
  • 财政年份:
    2020
  • 资助金额:
    $ 54.38万
  • 项目类别:
Disambiguating natural aging from Alzheimer's disease through changes in oral neuromechanics
通过改变口腔神经力学来消除自然衰老与阿尔茨海默病的关系
  • 批准号:
    10543237
  • 财政年份:
    2020
  • 资助金额:
    $ 54.38万
  • 项目类别:
Disambiguating natural aging from Alzheimer's disease through changes in oral neuromechanics
通过改变口腔神经力学来消除自然衰老与阿尔茨海默病的关系
  • 批准号:
    10055619
  • 财政年份:
    2020
  • 资助金额:
    $ 54.38万
  • 项目类别:
The neural basis of touch and proprioception in the primate orofacial sensorimotor cortex
灵长类口面部感觉运动皮层触觉和本体感觉的神经基础
  • 批准号:
    9895722
  • 财政年份:
    2018
  • 资助金额:
    $ 54.38万
  • 项目类别:

相似国自然基金

基于Volatility Basis-set方法对上海大气二次有机气溶胶生成的模拟
  • 批准号:
    41105102
  • 批准年份:
    2011
  • 资助金额:
    24.0 万元
  • 项目类别:
    青年科学基金项目
求解Basis Pursuit问题的数值优化方法
  • 批准号:
    11001128
  • 批准年份:
    2010
  • 资助金额:
    18.0 万元
  • 项目类别:
    青年科学基金项目
TB方法在有机和生物大分子体系计算研究中的应用
  • 批准号:
    20773047
  • 批准年份:
    2007
  • 资助金额:
    26.0 万元
  • 项目类别:
    面上项目

相似海外基金

Dissecting the gustatory and mechanosensory basis of feeding and egg-laying behaviour in disease-vectoring mosquitoes
剖析传播疾病的蚊子摄食和产卵行为的味觉和机械感觉基础
  • 批准号:
    489843
  • 财政年份:
    2023
  • 资助金额:
    $ 54.38万
  • 项目类别:
    Operating Grants
The neural basis of stereognosis and its application to neuroprosthetics
立体认知的神经基础及其在神经修复学中的应用
  • 批准号:
    10752482
  • 财政年份:
    2023
  • 资助金额:
    $ 54.38万
  • 项目类别:
The neural basis of touch and proprioreception in the primate orofacial sensorimotor cortex
灵长类口面部感觉运动皮层触觉和本体感受的神经基础
  • 批准号:
    10359788
  • 财政年份:
    2021
  • 资助金额:
    $ 54.38万
  • 项目类别:
The neural basis of touch and proprioception in the primate orofacial sensorimotor cortex
灵长类口面部感觉运动皮层触觉和本体感觉的神经基础
  • 批准号:
    9895722
  • 财政年份:
    2018
  • 资助金额:
    $ 54.38万
  • 项目类别:
Biophysical Basis of Functional Connectivity by MRI
MRI 功能连接的生物物理基础
  • 批准号:
    9915963
  • 财政年份:
    2012
  • 资助金额:
    $ 54.38万
  • 项目类别:
Biophysical Basis of Functional Connectivity by MRI
MRI 功能连接的生物物理基础
  • 批准号:
    10382296
  • 财政年份:
    2012
  • 资助金额:
    $ 54.38万
  • 项目类别:
'Mirror Touch' and the Neural Basis of Empathy (Response to: Society, Social Behaviour and the Neurosciences)
“镜像触摸”和同理心的神经基础(回应:社会、社会行为和神经科学)
  • 批准号:
    ES/F036248/1
  • 财政年份:
    2008
  • 资助金额:
    $ 54.38万
  • 项目类别:
    Research Grant
Infants' Neural Basis for Language Using New NIRS
使用新 NIRS 的婴儿语言神经基础
  • 批准号:
    7497359
  • 财政年份:
    2006
  • 资助金额:
    $ 54.38万
  • 项目类别:
Molecular Basis of Sensory Transduction in C elegans
秀丽隐杆线虫感觉转导的分子基础
  • 批准号:
    7029700
  • 财政年份:
    2004
  • 资助金额:
    $ 54.38万
  • 项目类别:
Molecular Basis of Sensory Transduction in C elegans
秀丽隐杆线虫感觉转导的分子基础
  • 批准号:
    6914157
  • 财政年份:
    2004
  • 资助金额:
    $ 54.38万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了