N-Glycosylation and Ocular Surface Homeostasis

N-糖基化和眼表稳态

基本信息

  • 批准号:
    10578975
  • 负责人:
  • 金额:
    $ 36.38万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-08-01 至 2024-07-31
  • 项目状态:
    已结题

项目摘要

Project Summary/Abstract All cells in nature are coated with a diverse mixture of glycans called the glycocalyx that functions as the primary interface with the environment. The structure of the glycocalyx is controlled by a series of glycosyltransferases, glycosidases and glycan-modifying enzymes that collectively assemble and process monosaccharide moieties to generate cell surface signatures in a tissue-specific manner. Recent findings indicate cell surface glycans perform important roles in stem cells and have a critical impact during both developmental processes and maintenance of homeostasis in the adult. This proposal centers on a major gap in our understanding of how cell surface glycans contribute to maintain limbal epithelial stem cell homeostasis. The proliferative capacity of the stem cells in tissues with high cellular turnover has to be precisely regulated to maintain regenerative capacity while preventing abnormal growth. It has become increasingly clear that modification of cell surface receptors by core fucosylation is critical to promote specific signal tranduction pathways and to regulate biological functions relevant to cell proliferation and differentiation. We hypothesize that lack of core fucosylation plays an important role in modulating the proliferative capacity of limbal epithelial stem cells and in promoting their self-renewal properties. The following specific aims will address this objective: (1) to identify glycan signatures in limbal epithelial stem cells and how they change during differentiation, (2) to investigate the contribution of FUT8, the only fucosyltransferase that catalyzes the addition of core fucose to N-glycans, in regulating growth factor receptor signaling and cellular turnover in limbal epithelial cells, and (3) to investigate whether core fucosylation can be used as a novel method to isolate and transplant limbal epithelial stem cells with high self-renewal and proliferative capacities. It is anticipated that this research will have significant translational relevance given the emerging focus on cell replacement therapies for limbal stem cell deficiency.
项目总结/文摘

项目成果

期刊论文数量(0)
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专利数量(0)

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Pablo Argueso其他文献

Pablo Argueso的其他文献

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{{ truncateString('Pablo Argueso', 18)}}的其他基金

Regulation of the immune cell glycome in corneal injury
角膜损伤中免疫细胞糖组的调节
  • 批准号:
    10602510
  • 财政年份:
    2020
  • 资助金额:
    $ 36.38万
  • 项目类别:
Regulation of the immune cell glycome in corneal injury
角膜损伤中免疫细胞糖组的调节
  • 批准号:
    10591019
  • 财政年份:
    2020
  • 资助金额:
    $ 36.38万
  • 项目类别:
Regulation of the immune cell glycome in corneal injury
角膜损伤中免疫细胞糖组的调节
  • 批准号:
    10636875
  • 财政年份:
    2020
  • 资助金额:
    $ 36.38万
  • 项目类别:
Regulation of the immune cell glycome in corneal injury
角膜损伤中免疫细胞糖组的调节
  • 批准号:
    10238839
  • 财政年份:
    2020
  • 资助金额:
    $ 36.38万
  • 项目类别:
N-Glycosylation and Ocular Surface Homeostasis
N-糖基化和眼表稳态
  • 批准号:
    10197130
  • 财政年份:
    2016
  • 资助金额:
    $ 36.38万
  • 项目类别:
N-Glycosylation and Ocular Surface Homeostasis
N-糖基化和眼表稳态
  • 批准号:
    9973535
  • 财政年份:
    2016
  • 资助金额:
    $ 36.38万
  • 项目类别:
N-glycosylation and ocular surface homeostasis
N-糖基化和眼表稳态
  • 批准号:
    9533581
  • 财政年份:
    2016
  • 资助金额:
    $ 36.38万
  • 项目类别:
N-glycosylation and ocular surface homeostasis
N-糖基化和眼表稳态
  • 批准号:
    9196100
  • 财政年份:
    2016
  • 资助金额:
    $ 36.38万
  • 项目类别:
N-Glycosylation and Ocular Surface Homeostasis
N-糖基化和眼表稳态
  • 批准号:
    10445276
  • 财政年份:
    2016
  • 资助金额:
    $ 36.38万
  • 项目类别:
CD147 and Corneal Wound Repair
CD147和角膜伤口修复
  • 批准号:
    8816764
  • 财政年份:
    2015
  • 资助金额:
    $ 36.38万
  • 项目类别:

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人眼表面电生理学
  • 批准号:
    10591279
  • 财政年份:
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  • 资助金额:
    $ 36.38万
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  • 财政年份:
    2023
  • 资助金额:
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开发用于表征驻留眼表微生物组的标准化资源。
  • 批准号:
    10661354
  • 财政年份:
    2023
  • 资助金额:
    $ 36.38万
  • 项目类别:
Redefining the immune landscape of the human ocular surface
重新定义人类眼表的免疫景观
  • 批准号:
    DP230102105
  • 财政年份:
    2023
  • 资助金额:
    $ 36.38万
  • 项目类别:
    Discovery Projects
Mitochondria and Mustard Damage at the Ocular Surface
眼表的线粒体和芥末损伤
  • 批准号:
    10708498
  • 财政年份:
    2023
  • 资助金额:
    $ 36.38万
  • 项目类别:
Defining bacterial members of the ocular surface microbiome and assessing stability over time
定义眼表微生物组的细菌成员并评估随时间推移的稳定性
  • 批准号:
    10668753
  • 财政年份:
    2023
  • 资助金额:
    $ 36.38万
  • 项目类别:
A Study of the Relationship between Ocular Surface Temperature and Anterior Segment Blood Flow in Dry Eye
干眼症眼表温度与眼前节血流量关系的研究
  • 批准号:
    22K09800
  • 财政年份:
    2022
  • 资助金额:
    $ 36.38万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Assessing how ocular surface nerves, immune cells, and epithelial cells communicate to encourage neuro-immune homeostasis
评估眼表神经、免疫细胞和上皮细胞如何沟通以促进神经免疫稳态
  • 批准号:
    10595234
  • 财政年份:
    2022
  • 资助金额:
    $ 36.38万
  • 项目类别:
2022 Cornea and Ocular Surface Biology, Pathology and Regeneration GRC/GRS
2022 角膜和眼表面生物学、病理学和再生 GRC/GRS
  • 批准号:
    10377627
  • 财政年份:
    2022
  • 资助金额:
    $ 36.38万
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Ocular surface applications of Descemet's membrane
后弹力层在眼表的应用
  • 批准号:
    10448019
  • 财政年份:
    2022
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