A Personalized Metabolomic Approach to Human Obesity and Weight Loss
针对人类肥胖和减肥的个性化代谢组学方法
基本信息
- 批准号:9196377
- 负责人:
- 金额:$ 59.61万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-01-01 至 2019-12-31
- 项目状态:已结题
- 来源:
- 关键词:Amino AcidsBehavior TherapyBehavioralBiological MarkersBloodBody Weight decreasedBranched-Chain Amino AcidsCardiovascular DiseasesCholesterolClinicalCoronary ArteriosclerosisDataDiseaseDyslipidemiasEventExerciseFibrinogenFoundationsFreezingGenesGlucoseGoalsHealthHealthcareHeart DiseasesHeterogeneityHumanHypertensionIndividualInsulin ResistanceInterventionMeasuresMetabolicMetabolic PathwayMethodsModelingMolecular ModelsMolecular ProfilingMorbidity - disease rateNon-Insulin-Dependent Diabetes MellitusObesityOperative Surgical ProceduresOverweightPatient CarePharmacologyPhenotypePlasmaPrediabetes syndromePrevalencePrimary Health CareResourcesRiskRisk FactorsTechnologyTestingTherapeutic InterventionUnited StatesWorkbiobankbiomarker identificationcardiovascular disorder preventioncardiovascular disorder riskcardiovascular risk factorcohortdisorder riskimprovedlipid metabolismmetabolomemetabolomicsmolecular modelingmortalitynovelnovel markerobesity managementpersonalized approachpersonalized interventionpersonalized medicinepredictive modelingpreventpublic health relevanceresponseweight loss intervention
项目摘要
DESCRIPTION (provided by applicant): The primary goal of this proposal is to identify and refine novel metabolic biomarkers that incrementally improve CVD risk prediction models and help predict the best obesity intervention to improve metabolic health, to begin to move towards a more personalized approach to obesity management for prevention of CVD. While obesity is a well-recognized risk factor for CVD-related morbidity and mortality, attributed to the increased prevalence of intermediate risk factors, there is heterogeneity in the prevalence of these risk factors in obese individuals.5 This disconnect leads to incomplete CVD risk prediction models and difficulty in identification of those obese individuals at greatest need for intensive therapeutic interventions for prevention of CVD events. Emerging molecular profiling technologies have begun to fill this gap. Building on a foundation of our previous work, we now propose here to use metabolomics profiling to develop biomarkers for identification of those obese individuals at greatest risk of CVD and, importantly, to build integrated "clinico-metabolic"
models that would facilitate personalization of obesity interventions to prevent CVD. Our Specific Aims are (1) to test the hypothesis that previously identified metabolic signatures are associated with CVD-related clinical measures in obese individuals and with obesity interventions; (2) to use "unbiased" metabolomics approaches to identify novel biomarkers associated with these biomarkers; and (3) to develop an integrated "clinico-molecular" model incorporating clinical variables and metabolic biomarkers.
描述(由申请人提供):该提案的主要目标是鉴定和改进新型代谢生物标志物,其逐步改善CVD风险预测模型并帮助预测改善代谢健康的最佳肥胖干预,以开始向预防CVD的更个性化的肥胖管理方法迈进。虽然肥胖是心血管疾病相关发病率和死亡率的公认风险因素,归因于中等风险因素的患病率增加,但肥胖个体中这些风险因素的患病率存在异质性。5这种脱节导致心血管疾病风险预测模型不完整,并且难以识别最需要强化治疗干预以预防心血管疾病事件的肥胖个体。新兴的分子分析技术已经开始填补这一空白。在我们以前工作的基础上,我们现在建议使用代谢组学分析来开发生物标志物,用于识别那些患有CVD风险最大的肥胖个体,重要的是,建立整合的“临床代谢”,
模型,这将有助于个性化的肥胖干预措施,以防止心血管疾病。我们的具体目标是:(1)检验先前鉴定的代谢特征与肥胖个体中CVD相关临床指标和肥胖干预相关的假设;(2)使用“无偏倚”代谢组学方法鉴定与这些生物标志物相关的新型生物标志物;(3)开发整合临床变量和代谢生物标志物的“临床-分子”模型。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Svati H. Shah其他文献
Brain‐derived neurotrophic factor rs6265 (Val66Met) polymorphism is associated with disease severity and incidence of cardiovascular events in a patient cohort
脑源性神经营养因子 rs6265 (Val66Met) 多态性与患者队列中疾病严重程度和心血管事件发生率相关
- DOI:
- 发表时间:
2017 - 期刊:
- 影响因子:4.8
- 作者:
Rong Jiang;M. Babyak;B. Brummett;E. Hauser;Svati H. Shah;R. Becker;I. Siegler;Abanish Singh;Carol Haynes;Megan Chryst;D. Craig;Redford B Williams - 通讯作者:
Redford B Williams
The Genetics of Thrombosis
血栓形成的遗传学
- DOI:
10.1007/978-1-60327-235-3_4 - 发表时间:
2010 - 期刊:
- 影响因子:3.3
- 作者:
Svati H. Shah;R. Becker - 通讯作者:
R. Becker
Insulin Growth Factor Phenotypes in Heart Failure with Preserved Ejection Fraction, an INSPIRE Registry and CATHGEN Study: IGF axis in HFpEF.
保留射血分数的心力衰竭中的胰岛素生长因子表型、INSPIRE 注册和 CATHGEN 研究:HFpEF 中的 IGF 轴。
- DOI:
- 发表时间:
2021 - 期刊:
- 影响因子:6
- 作者:
F. Haddad;J. A. Ataam;M. Amsallem;N. Cauwenberghs;T. Kuznetsova;Y. Rosenberg;R. Zamanian;I. Karakikes;B. Horne;J. Muhlestein;L. Kwee;Svati H. Shah;H. Maecker;S. Knight;K. Knowlton - 通讯作者:
K. Knowlton
Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk
对 5 万多例病例进行测序,确定了房颤风险背后的编码和结构变异
- DOI:
10.1038/s41588-025-02074-9 - 发表时间:
2025-03-06 - 期刊:
- 影响因子:29.000
- 作者:
Seung Hoan Choi;Sean J. Jurgens;Ling Xiao;Matthew C. Hill;Christopher M. Haggerty;Garðar Sveinbjörnsson;Valerie N. Morrill;Nicholas A. Marston;Lu-Chen Weng;James P. Pirruccello;David O. Arnar;Daniel Fannar Gudbjartsson;Helene Mantineo;Aenne S. von Falkenhausen;Andrea Natale;Arnljot Tveit;Bastiaan Geelhoed;Carolina Roselli;David R. Van Wagoner;Dawood Darbar;Doreen Haase;Elsayed Z. Soliman;Giovanni E. Davogustto;Goo Jun;Hugh Calkins;Jeffrey L. Anderson;Jennifer A. Brody;Jennifer L. Halford;John Barnard;John E. Hokanson;Jonathan D. Smith;Joshua C. Bis;Kendra Young;Linda S. B. Johnson;Lorenz Risch;Lorne J. Gula;Lydia Coulter Kwee;Mark D. Chaffin;Michael Kühne;Michael Preuss;Namrata Gupta;Navid A. Nafissi;Nicholas L. Smith;Peter M. Nilsson;Pim van der Harst;Quinn S. Wells;Renae L. Judy;Renate B. Schnabel;Renee Johnson;Roelof A. J. Smit;Stacey Gabriel;Stacey Knight;Tetsushi Furukawa;Thomas W. Blackwell;Victor Nauffal;Xin Wang;Yuan-I Min;Zachary T. Yoneda;Zachary W. M. Laksman;Connie R. Bezzina;Alvaro Alonso;Bruce M. Psaty;Christine M. Albert;Dan E. Arking;Dan M. Roden;Daniel I. Chasman;Daniel J. Rader;David Conen;David D. McManus;Diane Fatkin;Emelia J. Benjamin;Eric Boerwinkle;Gregory M. Marcus;Ingrid E. Christophersen;J. Gustav Smith;Jason D. Roberts;Laura M. Raffield;M. Benjamin Shoemaker;Michael H. Cho;Michael J. Cutler;Michiel Rienstra;Mina K. Chung;Morten S. Olesen;Moritz F. Sinner;Nona Sotoodehnia;Paulus Kirchhof;Ruth J. F. Loos;Saman Nazarian;Sanghamitra Mohanty;Scott M. Damrauer;Stefan Kaab;Susan R. Heckbert;Susan Redline;Svati H. Shah;Toshihiro Tanaka;Yusuke Ebana;Hilma Holm;Kari Stefansson;Christian T. Ruff;Marc S. Sabatine;Kathryn L. Lunetta;Steven A. Lubitz;Patrick T. Ellinor - 通讯作者:
Patrick T. Ellinor
Epigenetic profiling identifies novel genes for ascending aortic aneurysm formation with bicuspid aortic valves.
表观遗传分析识别了二叶式主动脉瓣升主动脉瘤形成的新基因。
- DOI:
- 发表时间:
2015 - 期刊:
- 影响因子:0.6
- 作者:
A. Shah;S. Gregory;D. Krupp;Sheng Feng;A. Dorogi;Carol Haynes;E. Grass;Shu;E. Hauser;W. Kraus;Svati H. Shah;G. Hughes - 通讯作者:
G. Hughes
Svati H. Shah的其他文献
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{{ truncateString('Svati H. Shah', 18)}}的其他基金
Immunogenetic Profiling for Risk of Primary Graft Dysfunction after Heart Transplantation
心脏移植后原发性移植物功能障碍风险的免疫遗传学分析
- 批准号:
10391731 - 财政年份:2021
- 资助金额:
$ 59.61万 - 项目类别:
Immunogenetic Profiling for Risk of Primary Graft Dysfunction after Heart Transplantation
心脏移植后原发性移植物功能障碍风险的免疫遗传学分析
- 批准号:
10515335 - 财政年份:2021
- 资助金额:
$ 59.61万 - 项目类别:
Inflammatory and Metabolic Biomarkers in Cardiovascular Complications with SARS-CoV-2
SARS-CoV-2 心血管并发症中的炎症和代谢生物标志物
- 批准号:
10303644 - 财政年份:2021
- 资助金额:
$ 59.61万 - 项目类别:
Inflammatory and Metabolic Biomarkers in Cardiovascular Complications with SARS-CoV-2
SARS-CoV-2 心血管并发症中的炎症和代谢生物标志物
- 批准号:
10426342 - 财政年份:2021
- 资助金额:
$ 59.61万 - 项目类别:
Metabolomic Quantitative Trait Locus (mQTL) Genetic Mapping in Human CVD
人类 CVD 代谢组学数量性状位点 (mQTL) 遗传图谱
- 批准号:
8150639 - 财政年份:2009
- 资助金额:
$ 59.61万 - 项目类别:
Metabolomic Quantitative Trait Locus (mQTL) Genetic Mapping in Human CVD
人类 CVD 代谢组学数量性状位点 (mQTL) 遗传图谱
- 批准号:
7894704 - 财政年份:2009
- 资助金额:
$ 59.61万 - 项目类别:
Metabolomic Quantitative Trait Locus (mQTL) Genetic Mapping in Human CVD
人类 CVD 代谢组学数量性状位点 (mQTL) 遗传图谱
- 批准号:
7636093 - 财政年份:2009
- 资助金额:
$ 59.61万 - 项目类别:
Metabolomic Quantitative Trait Locus (mQTL) Genetic Mapping in Human CVD
人类 CVD 代谢组学数量性状位点 (mQTL) 遗传图谱
- 批准号:
8470689 - 财政年份:2009
- 资助金额:
$ 59.61万 - 项目类别:
Metabolomic Quantitative Trait Locus (mQTL) Genetic Mapping in Human CVD
人类 CVD 代谢组学数量性状位点 (mQTL) 遗传图谱
- 批准号:
8318232 - 财政年份:2009
- 资助金额:
$ 59.61万 - 项目类别:
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