Enhancing experimental rigor through education in evidence synthesis

项目概要/摘要 现在发表的研究比历史上任何时候都多，而且这些研究在全世界都可以获得。 由于研究的迅速扩散，如果不是不可能的话， 可能影响研究和循证实践的重要发现。然而，有一个全面的 对文献的理解是推进知识的基础。这使得研究人员能够识别 现有的知识差距，使他们能够设计新的研究，以推动该领域的发展。的一种方法 实现这一点是通过严格的证据综合，或系统的方法来收集和分析 结果来自多个来源。在实践中，证据综合的使用需要改进，因为它们往往是 执行和报告不力，对公共卫生产生严重的下游影响。虽然有充足的 资源目前提供给研究人员的主题，他们没有得到充分利用，可能无法完全访问 所有可能从中受益的人。 国家神经疾病和中风研究所（NINDS）致力于提高基础知识， 通过及时传播神经疾病领域的科学发现。这次使命，跨越 翻译谱，通过加强证据合成技能得到充分支持，这可以防止浪费 研究投资。随着大脑和神经系统知识的迅速发展， 必须高度反思当前知识的变化，以确保他们的工作是相关的。培训 证据合成技能使之成为可能。 因此，本建议的目的是开发、评估和传播一系列教育模块 对科学的严格方法侧重于证据综合。拟议的模块将包括（1）一个 介绍证据合成，（2）开发研究问题和建议，（3）设计文献 搜索，（4）进行证据合成，（5）分析证据合成的数据，以及（6）报告 结果来自证据合成。这些模块将被设计为供不同水平的学习者使用 （入门级、中级和高级），并应用于整个翻译领域（基础科学、临床 科学和公共卫生）。模块的开发、评估和传播将通过迭代 多个利益攸关方（专家和非专业人员）的审查和反馈过程， 全面的最终产品。 有机会通过一个人人都可使用的平台，改进证据综合技术的使用 感兴趣的科学家在提高科学严谨性并最终改善公众健康方面具有巨大潜力。

PROJECT SUMMARY/ABSTRACT More research is being published now than any other time in history and that research is accessible worldwide. Due to the rapid proliferation of research, it can be difficult if not impossible for an individual to stay abreast of important findings which can impact research and evidence-based practice. Yet, having a comprehensive understanding of the literature is foundational to advancing knowledge. This allows a researcher to identify existing gaps in knowledge so that they can design new research to advance the area forward. One way to achieve this is through a rigorous evidence synthesis, or a systematic approach to gathering and analyzing results from multiple sources. In practice, the use of evidence syntheses requires improvement, as they are often poorly conducted and reported, which has serious downstream impacts on public health. While there are ample resources currently available to researchers on the topic, they are underutilized and may not be fully accessible to all individuals who may benefit from them. The National Institute of Neurological Disorders and Stroke (NINDS) seeks to improve fundamental knowledge through timely dissemination of scientific discoveries in the area of neurological disease. This mission, across the translational spectrum, is fully supported by enhancing skills in evidence synthesis, which can prevent waste in research investment. As knowledge of the brain and nervous system advances rapidly, scientists in this area have to be highly reflexive to changing current knowledge to ensure that their work is relevant. Training in the skills of evidence synthesis enables this. Accordingly, the aim of this proposal is to develop, evaluate, and disseminate a series of educational modules on rigorous approaches to science focused on evidence synthesis. The proposed modules will cover (1) an introduction to evidence synthesis, (2) developing a research question and proposal, (3) designing literature searches, (4) conducting an evidence synthesis, (5) analyzing data from an evidence synthesis, and (6) reporting results from an evidence synthesis. The modules will be designed to be utilized by different levels of learners (introductory, intermediate, and advanced) and apply across the translational spectrum (basic science, clinical science, and public health). Module development, evaluation, and dissemination will occur with an iterative process of review and feedback across multiple stakeholders (experts and lay persons alike) to create a useful and comprehensive final product. The opportunity to improve the use of evidence synthesis techniques through a platform that is accessible to all interested scientists has significant potential to enhance scientific rigor, and ultimately, improve public health.