Prediction and Validation of Oligodendrocyte Gene Regulatory Network from Multi-Omics

多组学预测和验证少突胶质细胞基因调控网络

基本信息

  • 批准号:
    10509768
  • 负责人:
  • 金额:
    $ 40.1万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-07-01 至 2024-06-30
  • 项目状态:
    已结题

项目摘要

PROJECT ABSTRACT Studies of several Intellectual/Developmental Disability (IDD) conditions have implicated white matter alterations in their pathogenesis, and mouse models of oligodendrocyte defects have validated mechanistic connections with cognitive disorders. In addition, many genetic causes of leukodystrophies have been identified, including mutations affecting the PLP1 gene in Pelizaeus-Merzbacher disease. However, due to the lack of tools to interpret significant variations in the noncoding genome, the ultimate influence of most genetic variants unfortunately remain uncharacterized. With the resources of PsychEncode and GTEx, a number of tools have emerged that can be integrated to create a network model of Transcription Factors (TFs) and their binding sites (TFBS), and several relevant datasets of the oligodendrocyte epigenome have emerged. The goal of this proposal is to integrate these epigenomic resources with newly available eQTL resources to develop a model that will improved predictive value in deciphering Whole Genome Sequencing (WGS) data from patients with a variety of developmental disabilities related to white matter changes. Along with creating the model, we will integrate motif analysis of known TFs involved in oligodendrocyte development (MYRF, SOX10, OLIG2, TCF4 and CHD7/8) to determine if variants alter transcription factor binding sites (TFBS) in oligodendrocyte-expressed genes. We anticipate that creation an improved oligodendrocyte GRN will lead to collaborative grant collaborations in several IDD conditions, such as Autism Spectrum Disorder (ASD), to elucidate the effects of noncoding changes in WGS and link them to perturbations in the oligodendrocyte network.
项目摘要

项目成果

期刊论文数量(0)
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John P Svaren其他文献

John P Svaren的其他文献

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{{ truncateString('John P Svaren', 18)}}的其他基金

Creation of a Schwann Cell Gene Regulatory Network
雪旺细胞基因调控网络的创建
  • 批准号:
    10581647
  • 财政年份:
    2022
  • 资助金额:
    $ 40.1万
  • 项目类别:
IDD Models Core
IDD 模型核心
  • 批准号:
    10678933
  • 财政年份:
    2021
  • 资助金额:
    $ 40.1万
  • 项目类别:
IDD Models Core
IDD 模型核心
  • 批准号:
    10239780
  • 财政年份:
    2021
  • 资助金额:
    $ 40.1万
  • 项目类别:
IDD Models Core
IDD 模型核心
  • 批准号:
    10450732
  • 财政年份:
    2021
  • 资助金额:
    $ 40.1万
  • 项目类别:
Epigenetic Regulation of Nerve Injury
神经损伤的表观遗传调控
  • 批准号:
    9396615
  • 财政年份:
    2017
  • 资助金额:
    $ 40.1万
  • 项目类别:
Epigenetic Regulation of Nerve Injury
神经损伤的表观遗传调控
  • 批准号:
    10207795
  • 财政年份:
    2017
  • 资助金额:
    $ 40.1万
  • 项目类别:
Regulation of PMP22 Expression in Peripheral Nerve
周围神经中 PMP22 表达的调节
  • 批准号:
    9293380
  • 财政年份:
    2014
  • 资助金额:
    $ 40.1万
  • 项目类别:
Regulation of PMP22 Expression in Peripheral Nerve
周围神经中 PMP22 表达的调节
  • 批准号:
    9069615
  • 财政年份:
    2014
  • 资助金额:
    $ 40.1万
  • 项目类别:
Regulation of PMP22 Expression in Peripheral Nerve
周围神经中 PMP22 表达的调节
  • 批准号:
    8759907
  • 财政年份:
    2014
  • 资助金额:
    $ 40.1万
  • 项目类别:
Epigenetic Regulation of Peripheral Nerve Myelination
周围神经髓鞘形成的表观遗传调控
  • 批准号:
    8575660
  • 财政年份:
    2013
  • 资助金额:
    $ 40.1万
  • 项目类别:

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