Administrative Core

行政核心

• 批准号: 10519073
• 负责人: William Mallory Grady
• 金额: $ 8.34万
• 依托单位: FRED HUTCHINSON CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-20 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10519073
• 关键词: Administrative Coordination; Architecture; Basic Science; Biology; Cancer Biology; Cancer Intervention and Surveillance Modeling Network; Collaborations; Communication; Communities; Data Analyses; Data Commons; Funding; Goals; Industrialization; Institution; Investigation; Logistics; Mission; Pathology; Process; Rana; Research; Research Personnel; Structure; System; Teleconferences; The Sun; Tissues; Translational Research; United States National Institutes of Health; adenoma; cancer genomics; data dissemination; data harmonization; data management; data sharing; data submission; gut microbiome; industry partner; innovation; meetings; member; operation; organizational structure; programs; protocol development; translational goal

SUMMARY The Administrative Core of our Translational and Basic Science of Adenomas Center (TBAC) will serve to optimize and integrate the investigative processes of the Project Labs between each other and the Project Labs with the Cores. The Administrative Core will provide logistical support, enhance communication, facilitate data dissemination and create a system for structured oversight of the projects by the PIs. The Administrative Core will also provide administrative support to facilitate collaborations and communications between the other TBEL Centers, the Coordinating and Data Management Center (CDMC); NCI staff, collaborating industrial and academic partners, and collaborating NCI programs (e.g. CISNET, NIST, etc.). The Administrative Core will provide guidance and enhance communication for and between the TBAC, TBEL Community members and external partners. The TBAC is comprised of three teams of investigators in the Project Labs: Project 1 (Grady, Yu, Maroni- Rana, Dai, Carter), Project 2 (Halberg, Spengler, Snow, Newton), and Project 3 (Dey, Morella, LaChance) and the Translational Pathology and Data Analysis Core (Matkowskyj, Pickhardt, Sun, Kendziorski, Dinh), who will function as a seamless unit though the coordination of the Administrative Core. The TBAC will interact closely with other TBEL Centers and the CDMC in its core mission to elucidate the translational and early biology of adenomas. The TBAC will also have collaborations with industrial partners and academic partners as needed to advance the Projects’ studies. The TBAC, other TBEL Centers, TBEL CDMC, industrial partners, and academic partners will collaborate on the studies in this proposal as well as on any resulting derivative studies that arise from the TBAC’s highly innovative, productive and significant program of investigation of the basic and translational biology of adenomas. The Administrative Core has the following Specific Aims/Goals: Specific Aim 1: To provide the organizational structure for supporting the key objectives of the TBAC Specific Aim 2: To provide efficiency in management of large-scale collaborative research efforts involving multiple institutions and multiple PDs/PIs Specific Aim 3: To coordinate with the TBEL CDMC and the TBEL community protocol development, biospecimen sharing, biospecimen blinding, data analysis, data sharing, data harmonization, data deposition, populating any data commons, and any other relevant functions deemed necessary for TBAC operations as well as for the larger TBEL community.

概括 我们的腺瘤转化和基础科学中心 (TBAC) 的行政核心将致力于 优化和整合项目实验室之间以及项目实验室之间的调查流程 与核心。行政核心将提供后勤支持、加强沟通、促进数据传输 传播并创建一个由 PI 对项目进行结构化监督的系统。行政核心 还将提供行政支持，以促进其他 TBEL 之间的合作和沟通 中心、协调和数据管理中心（CDMC）； NCI 工作人员、工业界和 学术合作伙伴以及 NCI 合作项目（例如 CISNET、NIST 等）。行政核心将 为 TBAC、TBEL 社区成员和他们之间提供指导并加强沟通 外部合作伙伴。 TBAC 由项目实验室的三个研究小组组成：项目 1（Grady、Yu、Maroni- Rana、Dai、Carter）、项目 2（Halberg、Spengler、Snow、Newton）和项目 3（Dey、Morella、LaChance）和 转化病理学和数据分析核心（Matkowskyj、Pickhardt、Sun、Kendziorski、Dinh），谁将 通过行政核心的协调，作为一个无缝单位发挥作用。 TBAC将密切互动 与其他 TBEL 中心和 CDMC 一起履行其核心使命，即阐明转化和早期生物学 腺瘤。 TBAC 还将根据需要与工业合作伙伴和学术合作伙伴进行合作 推进项目的研究。 TBAC、其他 TBEL 中心、TBEL CDMC、工业合作伙伴和学术界 合作伙伴将就本提案中的研究以及由此产生的任何衍生研究进行合作 来自 TBAC 高度创新、富有成效且意义重大的基础和研究项目 腺瘤的转化生物学。 行政核心有以下具体目的/目标： 具体目标 1：提供支持 TBAC 关键目标的组织结构 具体目标 2：提高大规模合作研究工作的管理效率，涉及 多个机构和多个 PD/PI 具体目标3：配合TBEL CDMC和TBEL社区协议开发， 生物样本共享、生物样本致盲、数据分析、数据共享、数据协调、数据沉积、 填充任何数据共享以及 TBAC 操作所需的任何其他相关功能 至于更大的 TBEL 社区。