Administrative Core

行政核心

• 批准号: 10707097
• 负责人: William Mallory Grady
• 金额: $ 33.59万
• 依托单位: FRED HUTCHINSON CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-20 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10707097
• 关键词: Administrative Coordination; Architecture; Basic Science; Biology; Cancer Biology; Cancer Intervention and Surveillance Modeling Network; Collaborations; Communication; Communities; Data Analyses; Data Commons; Data Coordinating Center; Education; Funding; Goals; Industrialization; Institution; Investigation; Mission; Pathology; Process; Productivity; Rana; Research; Research Personnel; Structure; System; Teleconferences; Tissues; Translational Research; United States National Institutes of Health; adenoma; cancer genomics; data dissemination; data harmonization; data sharing; data submission; gut microbiome; industry partner; innovation; meetings; member; operation; organizational structure; programs; protocol development; translational goal

SUMMARY The Administrative Core of our Translational and Basic Science of Adenomas Center (TBAC) will serve to optimize and integrate the investigative processes of the Project Labs between each other and the Project Labs with the Cores. The Administrative Core will provide logistical support, enhance communication, facilitate data dissemination and create a system for structured oversight of the projects by the PIs. The Administrative Core will also provide administrative support to facilitate collaborations and communications between the other TBEL Centers, the Coordinating and Data Management Center (CDMC); NCI staff, collaborating industrial and academic partners, and collaborating NCI programs (e.g. CISNET, NIST, etc.). The Administrative Core will provide guidance and enhance communication for and between the TBAC, TBEL Community members and external partners. The TBAC is comprised of three teams of investigators in the Project Labs: Project 1 (Grady, Yu, Maroni- Rana, Dai, Carter), Project 2 (Halberg, Spengler, Snow, Newton), and Project 3 (Dey, Morella, LaChance) and the Translational Pathology and Data Analysis Core (Matkowskyj, Pickhardt, Sun, Kendziorski, Dinh), who will function as a seamless unit though the coordination of the Administrative Core. The TBAC will interact closely with other TBEL Centers and the CDMC in its core mission to elucidate the translational and early biology of adenomas. The TBAC will also have collaborations with industrial partners and academic partners as needed to advance the Projects’ studies. The TBAC, other TBEL Centers, TBEL CDMC, industrial partners, and academic partners will collaborate on the studies in this proposal as well as on any resulting derivative studies that arise from the TBAC’s highly innovative, productive and significant program of investigation of the basic and translational biology of adenomas. The Administrative Core has the following Specific Aims/Goals: Specific Aim 1: To provide the organizational structure for supporting the key objectives of the TBAC Specific Aim 2: To provide efficiency in management of large-scale collaborative research efforts involving multiple institutions and multiple PDs/PIs Specific Aim 3: To coordinate with the TBEL CDMC and the TBEL community protocol development, biospecimen sharing, biospecimen blinding, data analysis, data sharing, data harmonization, data deposition, populating any data commons, and any other relevant functions deemed necessary for TBAC operations as well as for the larger TBEL community.

概括 我们的adenomas中心翻译和基础科学的行政核心（TBAC）将有助于 优化和整合彼此和项目实验室之间项目实验室的调查过程 与核心。行政核心将提供后勤支持，增强沟通，促进数据 传播并创建一个用于PIS对项目的结构化监督的系统。行政核心 还将提供行政支持，以促进其他TBEL之间的合作和沟通 中心，协调和数据管理中心（CDMC）； NCI员工，协作工业和 学术合作伙伴和合作NCI计划（例如Cisnet，NIST等）。行政核心将 提供指导并增强TBAC，TBEL社区成员以及 外部合作伙伴。 TBAC由项目实验室中的三支调查人员组成：项目1（Grady，Yu，Maroni- Rana，Dai，Carter），项目2（Halberg，Spengler，Snow，Newton）和Project 3（Dey，Morella，Lachance）和 转化病理学和数据分析核心（Matkowskyj，Pickhardt，Sun，Kendziorski，Dinh），他将 通过行政核心的协调，功能充当无缝单位。 TBAC将密切相互作用 与其他TBEL中心以及CDMC的核心使命，以阐明 腺瘤。 TBAC还将根据需要与工业合作伙伴和学术合作伙伴合作 推进项目的研究。 TBAC，其他TBEL中心，TBEL CDMC，工业合作伙伴和学术 合作伙伴将在本提案中以及任何产生的衍生研究中合作进行研究 根据TBAC的高度创新，富有成效和重要的基础投资计划 腺瘤的翻译生物学。 行政核心具有以下特定目标/目标： 特定目的1：提供支持TBAC的关键对象的组织结构 特定目标2：为涉及大规模协作研究的管理提供效率 多个机构和多个PDS/PI 特定目标3：与TBEL CDMC和TBEL社区协议开发协调， 生物测量共享，生物循环盲目，数据分析，数据共享，数据协调，数据沉积， 填充任何数据共享以及TBAC操作所必需的任何其他相关功能 至于较大的TBEL社区。