Liver Cancer Disparities in Alaska Native and American Indian People

阿拉斯加原住民和美洲印第安人的肝癌差异

基本信息

  • 批准号:
    10286757
  • 负责人:
  • 金额:
    $ 101.15万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-09-06 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

ABSTRACT: OVERALL COMPONENT - LIVER CANCER DISPARITIES IN AI/AN HCC is the fastest-rising major malignancy in the United States. While deaths related to lung, breast, prostate and colorectal cancer have declined dramatically by 40-53% between 1990 and 2016, HCC is the only major malignancy whose mortality is rising in both men and women and has had the highest average annual percentage change2. HCC is now the 6th leading cause of cancer-related death in the U.S. It is projected to surpass breast and colorectal cancer to become the 3rd leading cause of cancer-related death by 2030. American Indian/Alaska Native (AI/AN) people face a disproportionally high burden of HCC. AI/AN people have 2.4 times higher HCC incidence and 2.5 times higher HCC-related mortality than white persons. AI/AN people have a very high incidence and prevalence of conditions that cause HCC such as viral hepatitis C and B, alcohol use disorders, NAFLD/NASH, obesity and diabetes. Additionally, AI/AN patients have unique risk factors and pathogenetic mechanisms for HCC development, such as high prevalence of infection with HBV genotype F1b, unique mutations in the core region of HBV genotype F1b and high exposure to air pollutants (particulate matter <2.5µm or “PM2.5”), which are recognized carcinogens. The main focus of our Liver Cancer in AI/AN Disparities (Li-CAD) P20 program is to eliminate disparities in EARLY DETECTION. We believe that the most critical disparities and deficiencies in HCC management, and the greatest opportunities for improvement, lie in early detection. The overarching aim of this P20 Program is to apply novel, innovative, translational approaches to surveillance and early detection of HCC that are informed by unique aspects of HCC pathophysiology and epidemiology in AI/AN people in order to eliminate disparities, improve early detection and ultimately reduce HCC-related mortality. The overarching strategy is to introduce “Precision HCC Screening” based on HCC risk stratification and risk-based surveillance The P20 Li-CAD program will achieve the following AIMS: 1. PROJECT 1. Transform biomarker-based surveillance for early detection of HCC in medium and low-risk AI/AN patients. We will test and adapt exciting biomarker panels in AI/AN patients and develop innovative longitudinal (Bayesian) biomarker modeling strategies to maximize the performance characteristics of biomarker- based surveillance. 2. PROJECT 2. Develop novel risk stratification strategies and test abbreviated MRI-based surveillance for early detection of HCC in high-risk AI/AN patients. We will elucidate the role of HBV genotype-specific mutations in HCC; develop AI/AN-specific “HCC Risk Calculators” for HCC risk stratification and risk-based surveillance; and use these HCC Risk Calculators to identify high-risk patients for more intensive HCC surveillance strategies utilizing novel abbreviated MRI protocols, which will be tested in a small pilot and feasibility RCT
摘要:ai / an的总体成分-肝癌差异

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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William Mallory Grady其他文献

CPG island methylator phenotype and patients with multiple colorectal cancers
  • DOI:
    10.1016/s0016-5085(00)82254-4
  • 发表时间:
    2000-04-01
  • 期刊:
  • 影响因子:
  • 作者:
    William Mallory Grady;Sanford Markowitz;Joseph Willis
  • 通讯作者:
    Joseph Willis

William Mallory Grady的其他文献

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{{ truncateString('William Mallory Grady', 18)}}的其他基金

Administrative Core
行政核心
  • 批准号:
    10519073
  • 财政年份:
    2022
  • 资助金额:
    $ 101.15万
  • 项目类别:
Administrative Core-Biomarkers for optimizing risk prediction and early detection of cancers of the colon and esophagus
用于优化结肠癌和食道癌风险预测和早期检测的管理核心生物标志物
  • 批准号:
    10677826
  • 财政年份:
    2022
  • 资助金额:
    $ 101.15万
  • 项目类别:
Comprehensive atlas of advanced adenomas and their surrounding primed colon: A multi-omics evaluation and clinical impact assessment
晚期腺瘤及其周围的结肠的综合图谱:多组学评估和临床影响评估
  • 批准号:
    10707100
  • 财政年份:
    2022
  • 资助金额:
    $ 101.15万
  • 项目类别:
Biomarker Development Laboratory
生物标志物开发实验室
  • 批准号:
    10677827
  • 财政年份:
    2022
  • 资助金额:
    $ 101.15万
  • 项目类别:
Biomarkers for optimizing risk prediction and early detection of cancers of the colon and esophagus
用于优化结肠癌和食道癌风险预测和早期检测的生物标志物
  • 批准号:
    10677825
  • 财政年份:
    2022
  • 资助金额:
    $ 101.15万
  • 项目类别:
Comprehensive atlas of advanced adenomas and their surrounding primed colon: A multi-omics evaluation and clinical impact assessment
晚期腺瘤及其周围的结肠的综合图谱:多组学评估和临床影响评估
  • 批准号:
    10920978
  • 财政年份:
    2022
  • 资助金额:
    $ 101.15万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10707097
  • 财政年份:
    2022
  • 资助金额:
    $ 101.15万
  • 项目类别:
Comprehensive atlas of advanced adenomas and their surrounding primed colon: A multi-omics evaluation and clinical impact assessment
晚期腺瘤及其周围的结肠的综合图谱:多组学评估和临床影响评估
  • 批准号:
    10519074
  • 财政年份:
    2022
  • 资助金额:
    $ 101.15万
  • 项目类别:
The intestinal microbiome contribution to colon cancer and senescence
肠道微生物组对结肠癌和衰老的贡献
  • 批准号:
    10831334
  • 财政年份:
    2021
  • 资助金额:
    $ 101.15万
  • 项目类别:
The role of the senescent microenvironment on cancer initiating cells in the colon.
衰老微环境对结肠癌起始细胞的作用。
  • 批准号:
    10638374
  • 财政年份:
    2021
  • 资助金额:
    $ 101.15万
  • 项目类别:

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NNA 研究:合作研究:通过知识共同生产为阿拉斯加原住民社区打造具有复原力的水基础设施
  • 批准号:
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阿拉斯加原住民结直肠癌肿瘤和免疫微环境的深入分子和细胞分析
  • 批准号:
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开发一种评估土著历史创伤作为美洲印第安人/阿拉斯加原住民健康社会决定因素的工具
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  • 财政年份:
    2023
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