Administrative Core-Biomarkers for optimizing risk prediction and early detection of cancers of the colon and esophagus

项目总结 我们的生物标记表征中心(BCC)的管理核心(AC)将促进和优化 整合生物标记物发现和初步验证研究，由生物标记物发现实验室(BDL)和 开发和验证研究以创建临床级别的、符合CLIA标准的生物标记物分析 生物标记参考实验室(BRL)。管理核心将由中心管理员管理并运行 由BDL和BRL的PI。它将支持和加强跨BCC和跨EDRN通信、数据 传播以及数据审查和分析，这将促进BCC的核心使命，即发现和验证 临床分级生物标志物分析用于胃肠道癌症风险预测和早期发现行政核心将 为EDRN BCC和临床部之间的协作和沟通提供行政支持 验证中心(CVC)、数据管理中心(DMCC)；协作行业合作伙伴(例如Cernostics、 QIAGEN等)和学术合作伙伴，以及合作的NCI项目(例如，CISNET、NIST等)。通过 行政核心、BCC与其他EDRN BCC、CVC和DMCC、行业合作伙伴以及 学术伙伴不仅将在BCC的研究上合作，而且还将在由此产生的衍生品研究和 其他EDRN BCC和CVC项目，源于BCC的高度创新、多产和重要的 用于GI癌风险预测和早期检测的生物标记物发现和验证程序及其程序 其他商业信贷资料库。 行政核心有以下目标： 目标1：提供组织结构，以支持BCC的关键目标，即BDL的目标 以及BRL的科学和教育使命以及BDL和BRL Pi之间的成功合作 科学家、EDRN合作伙伴、学术合作伙伴和产业合作伙伴。 目标2：为大型协作研究工作提供高效的管理，涉及多个 各机构和多个个人数字助理/个人数字助理，包括地方和国家会议管理。 目标3：与EDRN DMCC协调制定方案、共享生物胺、生物胺盲法、 数据分析、数据共享、数据存储、填充Biomarker数据共享空间以及任何其他相关 被认为是BCC运营以及更大网络所必需的功能。

PROJECT SUMMARY The Administrative Core (AC) of our Biomarker Characterization Center (BCC) will facilitate and optimize the integration of biomarker discovery and initial validation studies by the Biomarker Discovery Lab (BDL) and the development and validation studies to create clinical-grade, CLIA compliant biomarker assays by the Biomarker Reference Lab (BRL). The Administrative Core will be managed by the Center Administrator and run by the PIs of the BDL and BRL. It will support and enhance cross BCC and cross EDRN communication, data dissemination and data review and analysis, which will promote the BCC’s core mission to discovery and validate clinical grade biomarker assays for GI cancer risk prediction and early detection The Administrative Core will provide administrative support for collaborations and communications between the EDRN BCCs, Clinical Validation Centers (CVCs), Data Management Center (DMCC); collaborating industrial partners (e.g. Cernostics, Qiagen, etc.) and academic partners, and collaborating NCI programs (e.g. CISNET, NIST, etc.). Through the functions of the Administrative Core, the BCC with other EDRN BCCs, CVC, and DMCC, industrial partners, and academic partners will collaborate not only on the BCC’s studies but also on resulting derivative studies and other EDRN BCC and CVC projects that arise from the BCC’s highly innovative, productive and significant program of biomarker discovery and validation for GI cancer risk prediction and early detection and the programs of other BCCs. The Administrative Core has the following aims: Aim 1: To provide the organizational structure for supporting the key objectives of the BCC, which are the BDL’s and BRL’s scientific and educational missions and the successful collaboration among the BDL and BRL PI and scientists, EDRN partners, academic partners and industrial partners. Aim 2: To provide efficiency in management of large-scale collaborative research efforts involving multiple institutions and multiple PDs/PIs, including local and national meetings management. Aim 3: To coordinate with EDRN DMCC for protocol development, biospecimen sharing, biospecimen blinding, data analysis, data sharing, data deposition, populating Biomarker Data Commons, and any other relevant functions deemed necessary for BCC operations as well as for the larger Network.