Administrative Core-Biomarkers for optimizing risk prediction and early detection of cancers of the colon and esophagus
用于优化结肠癌和食道癌风险预测和早期检测的管理核心生物标志物
基本信息
- 批准号:10677826
- 负责人:
- 金额:$ 41.74万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-05 至 2027-07-31
- 项目状态:未结题
- 来源:
- 关键词:Administrative CoordinationAdministratorBiological AssayBiological MarkersCLIA certifiedCancer Intervention and Surveillance Modeling NetworkClinicalCollaborationsCommunicationDataData AnalysesData CommonsData Coordinating CenterDevelopmentEarly Detection Research NetworkEarly DiagnosisEducationEnvironmentFundingFunding AgencyFutureIndustrializationInstitutionLettersMalignant neoplasm of esophagusMalignant neoplasm of gastrointestinal tractMissionProcessProductivityRanaResearchResearch PersonnelRunningScientistScreening for cancerStructureSystemTeleconferencesUnited States National Institutes of HealthValidationWorkbiomarker discoverybiomarker validationclinical biomarkersclinical developmentcolon cancer screeningdata disseminationdata sharingdata submissionindustry partnerinnovationinterestmeetingsmemberoperationorganizational structureprogramsprotocol developmentrisk predictionsuccessvalidation studies
项目摘要
PROJECT SUMMARY
The Administrative Core (AC) of our Biomarker Characterization Center (BCC) will facilitate and optimize
the integration of biomarker discovery and initial validation studies by the Biomarker Discovery Lab (BDL) and
the development and validation studies to create clinical-grade, CLIA compliant biomarker assays by the
Biomarker Reference Lab (BRL). The Administrative Core will be managed by the Center Administrator and run
by the PIs of the BDL and BRL. It will support and enhance cross BCC and cross EDRN communication, data
dissemination and data review and analysis, which will promote the BCC’s core mission to discovery and validate
clinical grade biomarker assays for GI cancer risk prediction and early detection The Administrative Core will
provide administrative support for collaborations and communications between the EDRN BCCs, Clinical
Validation Centers (CVCs), Data Management Center (DMCC); collaborating industrial partners (e.g. Cernostics,
Qiagen, etc.) and academic partners, and collaborating NCI programs (e.g. CISNET, NIST, etc.). Through the
functions of the Administrative Core, the BCC with other EDRN BCCs, CVC, and DMCC, industrial partners, and
academic partners will collaborate not only on the BCC’s studies but also on resulting derivative studies and
other EDRN BCC and CVC projects that arise from the BCC’s highly innovative, productive and significant
program of biomarker discovery and validation for GI cancer risk prediction and early detection and the programs
of other BCCs.
The Administrative Core has the following aims:
Aim 1: To provide the organizational structure for supporting the key objectives of the BCC, which are the BDL’s
and BRL’s scientific and educational missions and the successful collaboration among the BDL and BRL PI and
scientists, EDRN partners, academic partners and industrial partners.
Aim 2: To provide efficiency in management of large-scale collaborative research efforts involving multiple
institutions and multiple PDs/PIs, including local and national meetings management.
Aim 3: To coordinate with EDRN DMCC for protocol development, biospecimen sharing, biospecimen blinding,
data analysis, data sharing, data deposition, populating Biomarker Data Commons, and any other relevant
functions deemed necessary for BCC operations as well as for the larger Network.
项目摘要
我们的生物标志物表征中心(BCC)的行政核心(AC)将促进和优化
生物标志物发现实验室(BDL)的生物标志物发现和初步验证研究的整合,
开发和验证研究,以创建临床级,CLIA合规的生物标志物测定,由
生物标志物参考实验室(BRL)。管理核心将由中心管理员管理并运行
BDL和BRL的PI。它将支持和增强跨BCC和跨EDRN通信、数据
传播和数据审查和分析,这将促进BCC的核心使命,发现和验证
用于GI癌症风险预测和早期检测的临床级生物标志物测定
为EDRN BCC之间的协作和通信提供行政支持,临床
验证中心(CVC)、数据管理中心(DMCC);协作工业合作伙伴(例如Cernostics,
Qiagen等)和学术合作伙伴,以及合作的NCI计划(例如CISNET,NIST等)。通过
行政核心、BCC与其他EDRN BCC、CVC和DMCC、行业合作伙伴的职能,
学术合作伙伴不仅将在BCC的研究上进行合作,还将在由此产生的衍生研究上进行合作,
其他EDRN BCC和CVC项目,从BCC的高度创新,生产力和重大
用于GI癌症风险预测和早期检测的生物标志物发现和验证计划以及该计划
其他BCC
行政核心的目标如下:
目标1:提供支持BCC关键目标的组织结构,这些目标是BDL的
以及BRL的科学和教育任务,以及BDL和BRL PI之间的成功合作,
科学家、EDRN合作伙伴、学术合作伙伴和工业合作伙伴。
目标2:提高涉及多个领域的大规模合作研究工作的管理效率
会议管理是一个由各机构和多个方案执行主任/方案执行主任负责的工作,包括地方和国家会议管理。
目的3:与EDRN DMCC协调方案制定、生物标本共享、生物标本设盲,
数据分析、数据共享、数据沉积、填充生物标志物数据共享区以及任何其他相关的
被认为是BCC操作以及更大网络所必需的功能。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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William Mallory Grady其他文献
CPG island methylator phenotype and patients with multiple colorectal cancers
- DOI:
10.1016/s0016-5085(00)82254-4 - 发表时间:
2000-04-01 - 期刊:
- 影响因子:
- 作者:
William Mallory Grady;Sanford Markowitz;Joseph Willis - 通讯作者:
Joseph Willis
William Mallory Grady的其他文献
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{{ truncateString('William Mallory Grady', 18)}}的其他基金
Comprehensive atlas of advanced adenomas and their surrounding primed colon: A multi-omics evaluation and clinical impact assessment
晚期腺瘤及其周围的结肠的综合图谱:多组学评估和临床影响评估
- 批准号:
10707100 - 财政年份:2022
- 资助金额:
$ 41.74万 - 项目类别:
Biomarkers for optimizing risk prediction and early detection of cancers of the colon and esophagus
用于优化结肠癌和食道癌风险预测和早期检测的生物标志物
- 批准号:
10677825 - 财政年份:2022
- 资助金额:
$ 41.74万 - 项目类别:
Comprehensive atlas of advanced adenomas and their surrounding primed colon: A multi-omics evaluation and clinical impact assessment
晚期腺瘤及其周围的结肠的综合图谱:多组学评估和临床影响评估
- 批准号:
10920978 - 财政年份:2022
- 资助金额:
$ 41.74万 - 项目类别:
Comprehensive atlas of advanced adenomas and their surrounding primed colon: A multi-omics evaluation and clinical impact assessment
晚期腺瘤及其周围的结肠的综合图谱:多组学评估和临床影响评估
- 批准号:
10519074 - 财政年份:2022
- 资助金额:
$ 41.74万 - 项目类别:
Liver Cancer Disparities in Alaska Native and American Indian People
阿拉斯加原住民和美洲印第安人的肝癌差异
- 批准号:
10286757 - 财政年份:2021
- 资助金额:
$ 41.74万 - 项目类别:
The intestinal microbiome contribution to colon cancer and senescence
肠道微生物组对结肠癌和衰老的贡献
- 批准号:
10831334 - 财政年份:2021
- 资助金额:
$ 41.74万 - 项目类别:
The role of the senescent microenvironment on cancer initiating cells in the colon.
衰老微环境对结肠癌起始细胞的作用。
- 批准号:
10638374 - 财政年份:2021
- 资助金额:
$ 41.74万 - 项目类别:
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