Coordinating and Data Management Center for Acquired Resistance to Therapy Network
获得性治疗耐药网络协调和数据管理中心
基本信息
- 批准号:10516537
- 负责人:
- 金额:$ 105.04万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-01 至 2027-08-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdoptedBioconductorBioinformaticsBiometryBiostatistics Shared ResourceCancer Center Support GrantClinicalCollaborationsCombined Modality TherapyCommunitiesComprehensionComputer softwareCustomDataData Management ResourcesData ScienceData SetData Storage and RetrievalDatabasesDevelopmentDrug KineticsDrug resistanceEcosystemEnsureFosteringFundingGoalsHandImmunooncologyImmunotherapyInformaticsInformation TechnologyInfrastructureLeadMalignant NeoplasmsMethodsMultiomic DataNational Human Genome Research InstitutePatientsPharmacodynamicsPolicePoliciesPrincipal InvestigatorProductivityPubMedRecordsReproducibilityResearchResearch PersonnelResearch Project GrantsResistanceResource SharingResourcesServicesTextTherapeuticTranslatingUnited States National Institutes of HealthVisualizationbasebiobankbiomedical informaticscancer therapycloud basedcommunity engagementcostdata acquisitiondata ecosystemdata harmonizationdata integrationdata managementdata repositorydata resourcedata sharingdata sharing networksdata standardsdrug sensitivityexperiencegenomic dataimprovedinteroperabilitymultidisciplinaryopen sourceoperationoutreachpharmacokinetics and pharmacodynamicspre-clinicalpredictive markerquality assurancereal time monitoringrepositoryresistance mechanismresponsesupport networktherapy resistanttooltranslational oncologytumor microenvironmentvirtual
项目摘要
Project Summary
The goal of our proposed Coordinating and Data Management Center (CDMC) application is to coordinate the
activities across the Acquired Resistance to Therapy Network (ARTNet), and to manage, integrate and
disseminate the data and resources generated through the network. Leveraging cutting-edge multi-disciplinary
team approaches, we will support the ARTNet to inform new strategies that can be better translated to overcome
significant challenges in acquired resistance to cancer therapies. Our strategy is to enhance the productivity of
ARTNet investigators by fostering a collaborative and supportive research community, accelerate the progress
of ARTNet research by reducing barriers to accessing analytical expertise, ensure the reproducibility of ARTNet
data by deploying best practices for data acquisition and harmonization, and unleash the full potential of ARTNet
activities by developing enhanced tools to enable resource sharing to the broader scientific community.
First, we will provide a centralized administrative infrastructure to coordinate ARTNet activities, building upon
our well-functioning infrastructure that currently coordinates network studies under the umbrella of the NCI
Cancer Moonshot initiatives. Second, we will actively promote the ARTNet and engage in trans-consortium
interactions, where we will leverage our demonstrable experience in Cross-Moonshot outreach and
Bioconductor’s decades-long record in community engagement. Third, we will provide multidisciplinary analytical
expertise to support ARTNet collaborative research, leveraging five of Roswell Park CCSG’s shared resources:
Biostatistics, Bioinformatics, Biomedical Informatics, Pharmacokinetics/Pharmacodynamics, and Data Bank and
BioRepository. Our analytical support will be provided at no cost to ARTNet investigators in need of analytical
expertise, based on collaboration, transparency, and sharing. Fourth, we will develop improved data integration
software and workflows to enhance ARTNet’s research capacity, capitalizing on our extensive track-record in
developing NIH-supported Moonshot, Bioconductor and AnVIL ecosystems.
The main deliverables from the proposed aims will be administrative and outreach support to coordinate
network activities, facilitate network collaboration, and engage in interaction with the broader community (Aim
1); polices and infrastructures to ensure that all resources generated by the ARTNet will be findable in a
centralized virtual resource sharing repository, and that all resources will be shared with the broader scientific
community (Aim 2); workflows to ensure that all data generated by the ARTNet will be harmonized using
standards interoperable with the broader cancer data ecosystem, analysis tools to integrate ARTNet data and
facilitate cross-study analysis within and beyond the ARTNet, and multidisciplinary analytical supports to
accelerate ARTNet research progress.(Aim 3).
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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DAVID W. GOODRICH其他文献
DAVID W. GOODRICH的其他文献
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{{ truncateString('DAVID W. GOODRICH', 18)}}的其他基金
YAP1 and RB1 cooperate to regulate lung cancer lineage plasticity and therapeutic resistance
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10829724 - 财政年份:2022
- 资助金额:
$ 105.04万 - 项目类别:
Coordinating and Data Management Center for Acquired Resistance to Therapy Network
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10759015 - 财政年份:2019
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NOTCH signaling controls transformation to androgen independent neuroendocrine prostate cancer
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NOTCH signaling controls transformation to androgen independent neuroendocrine prostate cancer
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