University of Buffalo Clinical and Translational Science Institute - Supplement Schulyer

布法罗大学临床与转化科学研究所 - 补充 Schulyer

• 批准号: 10516586
• 负责人: Timothy F Murphy
• 金额: $ 4.76万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10516586
• 关键词: Academia; Address; African American; Area; Award; Biometry; Buffaloes; Center for Translational Science Activities; Cities; Clinic; Clinical; Clinical Research; Clinical Sciences; Communication; Communities; Data Analyses; Development; Diverse Workforce; Educational workshop; Environment; Fellowship; Formulation; Foundations; Funding; Future; Good Clinical Practice; Growth; Health; Health Care Research; Health Sciences; Healthcare; Healthcare Systems; Heart; Human; Individual; Influentials; Institutes; Institution; Institutional Review Boards; Laboratories; Learning; Longevity; Medical; Medical Education; Methodological Studies; New York; Parents; Participant; Pediatric Hospitals; Population; Population Analysis; Process; Public Health; Public Health Informatics; Recording of previous events; Reduce health disparities; Research; Research Design; Research Institute; Research Training; Schools; Science; Series; Smoking Behavior; Special Population; Speed; Strategic Planning; Testing; Tobacco use; Training; Translational Research; Translations; Underrepresented Minority; United States Food and Drug Administration; United States National Institutes of Health; Universities; Vision; Writing; biomedical informatics; career; education research; epidemiology study; experience; health disparity; improved; informatics tool; innovation; marginalized population; medical schools; multiple data sources; novel; novel strategies; programs; racial difference; response; skills; smartphone Application; smoking cessation; substance use; success; tool; translational pipeline

CTSA UL1 Abstract The Buffalo Translational Consortium (BTC), which includes the University at Buffalo (UB) health sciences schools, the major healthcare institutions in our region, four key research institutes, and five influential community partners, have embarked on a comprehensive strategic plan to build a strong foundation for clinical and translational research in response to our community needs. Buffalo is the second most populous city in New York State and has a rich cultural history. The proportion of underrepresented minorities in Buffalo in 2018 (50%) parallels that projected for the US in 2050, making Buffalo a microcosm of what the US will look like in 30 years. A similar proportion of our population experiences health disparities. The vision for our CTSA hub is to perform innovative research across the translational spectrum to improve the health of our community and the nation. We will develop, test, and share novel approaches to engage difficult-to-engage populations and reduce health disparities in our community, which represents a “population of the future”. Guided by our vision, the CTSA has catalyzed a transformation of our environment since our CTSA was first funded in August 2015 with remarkable growth in clinical and translational research. Further, in just the past year, the UB medical school has moved into a spectacular new building and our clinical partner, Kaleida Health, the largest healthcare system in the region, opened the new Oishei Children’s Hospital, both on the Buffalo Niagara Medical Campus and connected to the Clinical and Translational Research Center devoted entirely to clinical and translational research that opened in 2012. This rapid and continuing trajectory of growth in healthcare and research in the region has resulted in a new 21st century Academic Health Center with healthcare, medical education, and clinical and translational research on one campus in the heart of Buffalo, creating a foundation to enhance the impact of our CTSA even further. While launching our CTSA, we have prioritized participation in the national consortium through hosting and testing Innovation Labs as a team science tool, working with multiple hubs on initiatives to solve translational research barriers, and sharing tools that we have developed with the CTSA consortium, including novel health informatics tools. Our CTSA has five ambitious but achievable aims, including: 1) Accelerate innovative translational research with teams that engage communities, regional stakeholders, and the national consortium; 2) Train an excellent, diverse workforce to advance the translation of discoveries; 3) Enhance inclusion of special populations across the lifespan and difficult-to-engage populations; 4) Streamline clinical research processes focusing on quality and efficiency with emphasis on multisite studies; 5) Develop, test and share biomedical informatics tools to integrate data from multiple sources to speed translation. Guided by our vision to perform research to improve the health of our community and the nation, we will continue our momentum to expand translational research, train our diverse workforce, streamline processes, engage our community, and actively contribute to the national consortium. CTSA Diversity Supplement: “Understanding racial differences in smoking cessation app utilization and smoking behavior”; Schuyler C. Lawson, PI The candidate for this diversity supplement is of African American background. Completion of this supplement will allow him to examine racial differences in the utilization of smoking cessation smartphone apps and their impact on smoking behaviors. Additionally, he will be trained in longitudinal data analysis research skills, health disparities, substance use, and professional development in the areas of clinical and translational research. This proposal relates to the aims of the parent CTSA UL1 award such as Aims 2, 3 in that the research will involve training a candidate from a diverse background and the research is primarily focused on a marginalized population that is often characterized as difficult-to-engage. Those aims will be addressed through the analysis of the Population Assessment of Tobacco Use and Health (PATH) study, a nationally representative multi-wave study created under the auspices of the National Institutes of Health (NIH) and the Food and Drug Administration (FDA). To complete the proposed supplemental research, Mr. Lawson will utilize the following CTSA cores: (1 Biostatistics, Epidemiology, Research Design (BERD) Research Bootcamp to learn advanced statistical methodology, study design, and hypothesis formulation; (2 Good Clinical Practice Workshop Series to learn how to prepare IRB submissions and become more familiar with the fundamental principles of the protection of human research participants. Additionally, Mr. Lawson will utilize the following CLIMB program workshops to achieve the proposed supplemental research: (1) CLIMB Scientific Communication for Success Workshop series to bolster presentation skills, familiarize himself with the fellowship application process, and prepare him for careers in academia; (2) CLIMB Advanced Writing for Excellence in Research to learn proper grantsmanship, and develop finer scientific writing skills.

CTSA UL1摘要 布法罗翻译联盟(BTC)，其中包括布法罗大学(UB)健康科学 学校、我区主要医疗机构、四个重点研究机构和五个有影响力的社区 合作伙伴已着手制定全面的战略计划，为临床和医疗服务奠定坚实基础 翻译研究，以回应我们的社区需求。布法罗是纽约人口第二多的城市 纽约州，拥有丰富的文化历史。2018年布法罗市代表性不足的少数族裔比例(50%) 与美国2050年的预测相似，布法罗成为美国30年后面貌的一个缩影。 我们人口中有类似比例的人经历了健康差距。我们CTSA中心的愿景是实现 跨翻译领域的创新研究，以改善我们社区和国家的健康。 我们将开发、测试和分享新的方法，以吸引难以参与的人群并减少健康 我们社会的不平等，代表着“未来的人口”。在我们的愿景指导下，CTSA已经 自从我们的CTSA于2015年8月首次获得资金以来，我们的环境发生了显著的变化 临床和转化性研究的增长。此外，就在过去的一年里，亚利桑那州立大学医学院已经搬进了 一座壮观的新建筑和我们的临床合作伙伴，该地区最大的医疗系统Kaleida Health， 开设了新的Oishei儿童医院，既位于布法罗尼亚加拉医学院，又与 临床和翻译研究中心完全致力于临床和翻译研究，该中心于 2012年。该地区医疗保健和研究的这种快速和持续的增长轨迹导致了 新的21世纪学术健康中心，提供医疗保健、医学教育、临床和翻译服务 在布法罗市中心的一个校园进行研究，为提高我们CTSA的影响力奠定了基础 再远一点。在推出我们的CTSA的同时，我们通过主办优先参与国家财团 将创新实验室作为团队科学工具进行测试，与多个中心合作解决翻译 研究障碍，以及我们与CTSA联盟开发的共享工具，包括新型健康 信息学工具。我们的CTSA有五个雄心勃勃但可以实现的目标，包括：1)加快创新 与社区、区域利益攸关方和国家财团合作的团队进行翻译研究； 2)培训一支优秀的、多样化的劳动力队伍，以促进发现成果的转化；3)加强对特殊技术的纳入 生命周期内的人群和难以参与的人群；4)简化临床研究流程 注重质量和效率，注重多点研究；5)开发、测试和共享生物医学 用于集成来自多个来源的数据以加快翻译速度的信息学工具。在我们的愿景指引下表演 为了改善我们社区和国家的健康，我们将继续扩大我们的势头 翻译研究，培训我们多样化的员工队伍，简化流程，让我们的社区参与进来，并积极 向国家财团捐款。 CTSA多样性补充：《了解戒烟应用程序使用和使用中的种族差异 《吸烟行为》，Schuyler C.Lawson，Pi 这份多元化副刊的候选人是非洲裔美国人。填写本补充资料 将允许他检查使用戒烟智能手机应用程序的种族差异以及他们的 对吸烟行为的影响。此外，他还将接受纵向数据分析研究技能、健康 临床和转化性研究领域的差异、物质使用和专业发展。 这项建议与CTSA UL1奖的目标有关，如AIMS 2、3，因为研究将 涉及到培训来自不同背景的候选人，研究主要集中在边缘人群 经常被描述为难以接触的人群。这些目标将通过分析加以解决 的人口烟草使用与健康评估(PATH)研究，一个具有全国代表性的多浪潮 这项研究是由美国国立卫生研究院(NIH)和美国食品和药物管理局赞助的 (FDA)。 为了完成拟议的补充研究，劳森先生将使用以下CTSA核心：(1 生物统计学、流行病学、研究设计(BERD)研究训练营学习高级统计学 方法学、研究设计和假设表述；(2个好的临床实践研讨会系列，了解如何 准备IRB意见书，并更熟悉保护人权的基本原则 研究参与者。此外，劳森先生将利用以下攀登计划研讨会来实现 拟议的补充研究：(1)攀登科学传播促进成功研讨会系列，以 增强演讲技巧，熟悉奖学金申请流程，为职业生涯做好准备 在学术界；(2)攀登研究卓越高级写作课程，以学习适当的资质；以及 培养更好的科学写作技能。