Antivirus Pandemic Preparedness EuropeAn pLatform (Appeal)
欧洲防病毒大流行准备平台(呼吁)
基本信息
- 批准号:10110329
- 负责人:
- 金额:$ 60.54万
- 依托单位:
- 依托单位国家:英国
- 项目类别:EU-Funded
- 财政年份:2024
- 资助国家:英国
- 起止时间:2024 至 无数据
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Developing new antiviral treatment against viruses and particularly high-priority emerging and re-emerging viruses aslisted by the WHO, remains crucial as, among other aspects, the viruses evolve under selection. Broad spectrum host-directed antiviral drugs (HDA) are promising therapeutic options, however the robust identification of relevant host factors by genome-wide knockout screens is challenging due to low consistency in the resulting hits. Our project aims to (1) establish a computational and experimental pipeline to identify and validate an antiviral for these viruses, and (2) identify at least one broad spectrum antiviral drug against potential emerging and re emerging viruses as listed by the WHO. To address these, we will implement a drug selection pipeline following several strategies: We will employ (i) machine learning, based on data from knockout screens, proteomics, protein interaction, transcriptomics of infected cells with pandemic-related viruses, Genome-Wide Association Studies, and generic gene descriptors, (ii) High Density Cell Arrays, which provide much more detailed readouts compared to state of the art pooled knockout screens, (iii) primary cell cultures obtained from a diverse array of human tissues, as they are more appropriate to study the host cell physiology during infection, compared to cancer cell lines, and (iv) use the pipeline to identify host restriction factors, which, when activated, challenge the virus; followed by innovative drug development and delivery based on small activating RNA. The pipeline comprises an Expedited Arm for which broad spectrum antiviral drugs for repurposing will be selected followed by in vitro and in vivo efficacy testing, and a clinical trial as a proof of concept. The elaborated Arm includes all strategies (i)-(iv) and will provide a sustainable pandemic preparedness pipeline ready-to-operate to identify the appropriate treatment against the emerging virus at the early time of a new outbreak.
开发新的抗病毒治疗,特别是WHO列出的高度优先的新出现和重新出现的病毒,仍然至关重要,因为除其他方面外,病毒在选择下进化。广谱宿主定向抗病毒药物(HDA)是有前途的治疗选择,然而,由于所得命中的低一致性,通过全基因组敲除筛选来稳健地鉴定相关宿主因子是具有挑战性的。我们的项目旨在(1)建立一个计算和实验管道,以确定和验证这些病毒的抗病毒药物,(2)确定至少一种广谱抗病毒药物,以对抗WHO列出的潜在新出现和重新出现的病毒。为了解决这些问题,我们将实施以下几种策略的药物选择管道:我们将采用(i)机器学习,基于来自敲除筛选,蛋白质组学,蛋白质相互作用,大流行相关病毒感染细胞的转录组学,全基因组关联研究和通用基因描述符的数据,(ii)高密度细胞阵列,其提供了比现有技术的合并敲除筛选更详细的读数,(iii)从多种人类组织获得的原代细胞培养物,因为它们更适合于研究感染期间的宿主细胞生理学,与癌细胞系相比,以及(iv)使用管道来识别宿主限制因子,当激活时,挑战病毒;然后是基于小激活RNA的创新药物开发和交付。该管道包括一个加速组,将选择用于再利用的广谱抗病毒药物,然后进行体外和体内疗效测试,并进行临床试验作为概念验证。详细制定的应急机制包括所有战略(i)-(iv),并将提供一个可持续的大流行防备渠道,随时可以运作,以便在新的疫情爆发初期确定针对新出现病毒的适当治疗方法。
项目成果
期刊论文数量(0)
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其他文献
吉治仁志 他: "トランスジェニックマウスによるTIMP-1の線維化促進機序"最新医学. 55. 1781-1787 (2000)
Hitoshi Yoshiji 等:“转基因小鼠中 TIMP-1 的促纤维化机制”现代医学 55. 1781-1787 (2000)。
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LiDAR Implementations for Autonomous Vehicle Applications
- DOI:
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2021 - 期刊:
- 影响因子:0
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吉治仁志 他: "イラスト医学&サイエンスシリーズ血管の分子医学"羊土社(渋谷正史編). 125 (2000)
Hitoshi Yoshiji 等人:“血管医学与科学系列分子医学图解”Yodosha(涉谷正志编辑)125(2000)。
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Effect of manidipine hydrochloride,a calcium antagonist,on isoproterenol-induced left ventricular hypertrophy: "Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,K.,Teragaki,M.,Iwao,H.and Yoshikawa,J." Jpn Circ J. 62(1). 47-52 (1998)
钙拮抗剂盐酸马尼地平对异丙肾上腺素引起的左心室肥厚的影响:“Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,
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{{ truncateString('', 18)}}的其他基金
An implantable biosensor microsystem for real-time measurement of circulating biomarkers
用于实时测量循环生物标志物的植入式生物传感器微系统
- 批准号:
2901954 - 财政年份:2028
- 资助金额:
$ 60.54万 - 项目类别:
Studentship
Exploiting the polysaccharide breakdown capacity of the human gut microbiome to develop environmentally sustainable dishwashing solutions
利用人类肠道微生物群的多糖分解能力来开发环境可持续的洗碗解决方案
- 批准号:
2896097 - 财政年份:2027
- 资助金额:
$ 60.54万 - 项目类别:
Studentship
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2780268 - 财政年份:2027
- 资助金额:
$ 60.54万 - 项目类别:
Studentship
Likelihood and impact of severe space weather events on the resilience of nuclear power and safeguards monitoring.
严重空间天气事件对核电和保障监督的恢复力的可能性和影响。
- 批准号:
2908918 - 财政年份:2027
- 资助金额:
$ 60.54万 - 项目类别:
Studentship
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质子、α 和 γ 辐照辅助应力腐蚀开裂:了解燃料-不锈钢界面
- 批准号:
2908693 - 财政年份:2027
- 资助金额:
$ 60.54万 - 项目类别:
Studentship
Field Assisted Sintering of Nuclear Fuel Simulants
核燃料模拟物的现场辅助烧结
- 批准号:
2908917 - 财政年份:2027
- 资助金额:
$ 60.54万 - 项目类别:
Studentship
Assessment of new fatigue capable titanium alloys for aerospace applications
评估用于航空航天应用的新型抗疲劳钛合金
- 批准号:
2879438 - 财政年份:2027
- 资助金额:
$ 60.54万 - 项目类别:
Studentship
CDT year 1 so TBC in Oct 2024
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- 批准号:
2879865 - 财政年份:2027
- 资助金额:
$ 60.54万 - 项目类别:
Studentship
Developing a 3D printed skin model using a Dextran - Collagen hydrogel to analyse the cellular and epigenetic effects of interleukin-17 inhibitors in
使用右旋糖酐-胶原蛋白水凝胶开发 3D 打印皮肤模型,以分析白细胞介素 17 抑制剂的细胞和表观遗传效应
- 批准号:
2890513 - 财政年份:2027
- 资助金额:
$ 60.54万 - 项目类别:
Studentship
Understanding the interplay between the gut microbiome, behavior and urbanisation in wild birds
了解野生鸟类肠道微生物组、行为和城市化之间的相互作用
- 批准号:
2876993 - 财政年份:2027
- 资助金额:
$ 60.54万 - 项目类别:
Studentship
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