UofL RBL Pandemic Preparedness and Response Integrated Research Core

摘要：大流行防备和应对综合研究服务核心 大流行防备和反应综合研究服务核心(PAPR核心)应支持所有 路易斯维尔大学(UofL)区域生物遏制中心进行的风险组3(RG3)病原体研究 实验室(RBL)。与NIAID大流行防备任务相一致，PAPR核心将为 UofL的调查人员，我们的地区学术和工业合作伙伴，在NBL/RBL合作调查人员 希望利用我们的设施和专业知识的网络和其他调查人员。PAPR核心支持基金 研究计划通过提供研究设计方面的科学专业知识，劳动力来支持两者在体外的执行 和活体BSL-3研究，以及数据分析和解释服务，最终发布了 向主办方调查员提交综合研究报告。PAPR核心应在收回成本的情况下运行 商业模式，收入再投资于核心服务。PAPR核心的目标是：(1)支持 UofL RBL建立的Rg3病原体感染模型的持续完善；(2)支持持续 改进UofL RBL建立的RG3病原体感染模型；(3)使对影响的调查成为可能 老龄化和慢性代谢性疾病对RG3病原体感染的影响；以及(4)能够研究 环境毒物暴露对Rg3病原菌感染的影响

SUMMARY: PANDEMIC PREPAREDNESS AND RESPONSE INTEGRATED RESEARCH SERVICES CORE The Pandemic Preparedness and Response Integrated Research Services Core (PaPR Core) shall support all Risk Group 3 (RG3) pathogen studies conducted at the University of Louisville (UofL) Regional Biocontainment Laboratory (RBL). In alignment with the NIAID Pandemic Preparedness Mission, the PaPR Core shall serve investigators at UofL, our regional academic and industrial partners, collaborating investigators in the NBL/RBL network and other investigators who wish to avail of our facilities and expertise. The PaPR Core supports funded research programs by providing scientific expertise on study design, labor to support execution of both in vitro and in vivo BSL-3 studies, and data analysis and interpretation services that culminate in issuing a comprehensive study report to the sponsor investigator. The PaPR Core shall operate on a cost-recovery business model, with revenue re-invested in core services. The aims of the PaPR Core are to: (1) Support continuous refinement of RG3 pathogen infection models established at UofL RBL.; (2) Support continuous refinement of RG3 pathogen infection models established at UofL RBL; (3) Enable investigations on the impact of aging and chronic metabolic disease on RG3 pathogen infections; and (4) Enable studies on the impact of environmental toxicant exposure on RG3 pathogen infections.