UofL RBL Pandemic Preparedness and Response Integrated Research Core

UofL RBL 流行病防范和应对综合研究核心

基本信息

批准号：
10793921
负责人：
KENNETH E PALMER
金额：
$ 179.3万
依托单位：
UNIVERSITY OF LOUISVILLE
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-18 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10793921
关键词：
Aging Alcoholic Liver Diseases Ally Alphavirus Animal Model Arthritogenic Attention Autopsy Blood Chemical Analysis Businesses COVID-19 Cardiometabolic Disease Centers of Research Excellence Chronic Chronic Disease Clinical Collaborations Communicable Diseases Communities Data Data Analyses Development Disease Disease Outcome Elderly Emerging Communicable Diseases Ensure Environmental Exposure Environmental Impact Environmental Medicine Funding Health Hematology Immunology In Vitro Industrialization Infection Investigation Investigational Drugs Investments Japanese encephalitis virus Laboratories Measurement Metabolic Metabolic Diseases Mission Modeling National Institute of Allergy and Infectious Disease Outcome Outcome Study Pathogenesis Pathology Persons Pharmacodynamics Physiological Positron Positron-Emission Tomography Powassan virus Readiness Recovery Reporting Reproducibility Research Research Design Research Personnel Risk SARS-CoV-2 infection Scanning Semliki forest virus Service delivery model Services System Testing Toxic Environmental Substances Toxicant exposure Translational Research United States National Institutes of Health Universities Viral Pathogenesis Virus Virus Diseases Vulnerable Populations West Nile virus Whole Body Plethysmography Workforce Development X-Ray Computed Tomography chikungunya cost environmental toxicology future pandemic global environment good laboratory practice in vivo in vivo Model in vivo imaging infectious disease model instrument instrumentation medical countermeasure mouse model operation pandemic potential pandemic preparedness pandemic response pathogen programs pulmonary function response

项目摘要

SUMMARY: PANDEMIC PREPAREDNESS AND RESPONSE INTEGRATED RESEARCH SERVICES CORE The Pandemic Preparedness and Response Integrated Research Services Core (PaPR Core) shall support all Risk Group 3 (RG3) pathogen studies conducted at the University of Louisville (UofL) Regional Biocontainment Laboratory (RBL). In alignment with the NIAID Pandemic Preparedness Mission, the PaPR Core shall serve investigators at UofL, our regional academic and industrial partners, collaborating investigators in the NBL/RBL network and other investigators who wish to avail of our facilities and expertise. The PaPR Core supports funded research programs by providing scientific expertise on study design, labor to support execution of both in vitro and in vivo BSL-3 studies, and data analysis and interpretation services that culminate in issuing a comprehensive study report to the sponsor investigator. The PaPR Core shall operate on a cost-recovery business model, with revenue re-invested in core services. The aims of the PaPR Core are to: (1) Support continuous refinement of RG3 pathogen infection models established at UofL RBL.; (2) Support continuous refinement of RG3 pathogen infection models established at UofL RBL; (3) Enable investigations on the impact of aging and chronic metabolic disease on RG3 pathogen infections; and (4) Enable studies on the impact of environmental toxicant exposure on RG3 pathogen infections.

摘要：大流行准备和综合研究服务核心大流行的准备和反应综合研究服务核心（PAPR核心）应支持所有风险组3（RG3）在路易斯维尔大学（UOFL）区域生物内在进行的病原体研究实验室（RBL）。为了与NIAID大流行的准备任务保持一致，PAPR核心应服务 UOFL的调查人员，我们的区域学术和工业合作伙伴，与NBL/RBL合作的研究人员网络和其他希望利用我们的设施和专业知识的调查人员。 PAPR核心支持资助研究计划通过提供研究设计的科学专业知识，劳动以支持两者的执行以及体内BSL-3研究以及数据分析和解释服务，最终发出综合研究报告给赞助商研究者。 PAPR核心应进行成本恢复商业模式，收入重新投资于核心服务。 PAPR核心的目的是：（1）支持在UOFL RBL建立的RG3病原体感染模型的连续细化。（2）支持连续在UOFL RBL建立的RG3病原体感染模型的细化；（3）对影响进行调查 RG3病原体感染的衰老和慢性代谢疾病；（4）启用有关影响的研究 RG3病原体感染的环境有毒物质暴露。