UofL RBL Pandemic Preparedness and Response Integrated Research Core

UofL RBL 流行病防范和应对综合研究核心

• 批准号: 10793921
• 负责人: KENNETH E PALMER
• 金额: $ 179.3万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10793921
• 关键词: Aging; Alcoholic Liver Diseases; Ally; Alphavirus; Animal Model; Arthritogenic; Attention; Autopsy; Blood Chemical Analysis; Businesses; COVID-19; Cardiometabolic Disease; Centers of Research Excellence; Chronic; Chronic Disease; Clinical; Collaborations; Communicable Diseases; Communities; Data; Data Analyses; Development; Disease; Disease Outcome; Elderly; Emerging Communicable Diseases; Ensure; Environmental Exposure; Environmental Impact; Environmental Medicine; Funding; Health; Hematology; Immunology; In Vitro; Industrialization; Infection; Investigation; Investigational Drugs; Investments; Japanese encephalitis virus; Laboratories; Measurement; Metabolic; Metabolic Diseases; Mission; Modeling; National Institute of Allergy and Infectious Disease; Outcome; Outcome Study; Pathogenesis; Pathology; Persons; Pharmacodynamics; Physiological; Positron; Positron-Emission Tomography; Powassan virus; Readiness; Recovery; Reporting; Reproducibility; Research; Research Design; Research Personnel; Risk; SARS-CoV-2 infection; Scanning; Semliki forest virus; Service delivery model; Services; System; Testing; Toxic Environmental Substances; Toxicant exposure; Translational Research; United States National Institutes of Health; Universities; Viral Pathogenesis; Virus; Virus Diseases; Vulnerable Populations; West Nile virus; Whole Body Plethysmography; Workforce Development; X-Ray Computed Tomography; chikungunya; cost; environmental toxicology; future pandemic; global environment; good laboratory practice; in vivo; in vivo Model; in vivo imaging; infectious disease model; instrument; instrumentation; medical countermeasure; mouse model; operation; pandemic potential; pandemic preparedness; pandemic response; pathogen; programs; pulmonary function; response

SUMMARY: PANDEMIC PREPAREDNESS AND RESPONSE INTEGRATED RESEARCH SERVICES CORE The Pandemic Preparedness and Response Integrated Research Services Core (PaPR Core) shall support all Risk Group 3 (RG3) pathogen studies conducted at the University of Louisville (UofL) Regional Biocontainment Laboratory (RBL). In alignment with the NIAID Pandemic Preparedness Mission, the PaPR Core shall serve investigators at UofL, our regional academic and industrial partners, collaborating investigators in the NBL/RBL network and other investigators who wish to avail of our facilities and expertise. The PaPR Core supports funded research programs by providing scientific expertise on study design, labor to support execution of both in vitro and in vivo BSL-3 studies, and data analysis and interpretation services that culminate in issuing a comprehensive study report to the sponsor investigator. The PaPR Core shall operate on a cost-recovery business model, with revenue re-invested in core services. The aims of the PaPR Core are to: (1) Support continuous refinement of RG3 pathogen infection models established at UofL RBL.; (2) Support continuous refinement of RG3 pathogen infection models established at UofL RBL; (3) Enable investigations on the impact of aging and chronic metabolic disease on RG3 pathogen infections; and (4) Enable studies on the impact of environmental toxicant exposure on RG3 pathogen infections.

摘要：大流行病准备和应对综合研究服务核心 流行病防范和应对综合研究服务核心（PaPR核心）将支持所有 在路易斯维尔大学（UofL）区域生物防护进行的风险组3（RG 3）病原体研究 实验室（RBL）。根据NIAID的大流行准备使命，PaPR核心应 UofL的调查人员，我们的区域学术和工业合作伙伴，NBL/RBL的合作调查人员 网络和其他调查人员谁希望利用我们的设施和专业知识。PaPR核心支持资助 通过提供研究设计方面的科学专业知识，支持体外研究和 和体内BSL-3研究，以及数据分析和解释服务，最终发布一份 向申办者研究者提交综合研究报告。PaPR核心应在成本回收的基础上运作 商业模式，收入再投资于核心服务。PaPR核心的目标是：（1）支持 不断改进在UofL RBL建立的RG 3病原体感染模型。(2)支持连续 完善在UofL RBL建立的RG 3病原体感染模型;（3）能够调查对 衰老和慢性代谢疾病对RG 3病原体感染的影响;以及（4）能够研究 环境毒物暴露对RG 3病原体感染的影响。