UofL RBL Operations, Workforce Development and Pandemic Preparedness Research

总结（总体）： 路易斯维尔大学区域生物防护实验室（RBL）由大学中心运营， 生物防御和新发传染病预测医学（CPM）。RBL是一种区域资源 促进转化研究，以开发诊断，免疫学，治疗和疫苗，以减轻 生物防御和新出现的传染病威胁。我们的中心经营唯一的BSL-3和ABSL-3设施 目前在肯塔基州的联邦运作。CPM的任务是准备和回应公众 卫生紧急情况，如COVID-19大流行。 路易斯维尔大学（UofL）CPM RBL的广泛，长期目标和目标是： 1.为区域和国家生物医学研究界提供最先进的研究服务， 从过去的大流行病和生物战经验中学习，有效预测和减轻未来 新出现的传染病威胁。 2.管理、维护和运行UofL RBL，以满足国家和地区的生物防护需求 适合研究第3类危险病原体和其他生物威胁的设施。 3.遵循BSL-3和ABSL-3工作实践的持续改进理念，并确保 所有需要进入BSL-3和ABSL-3防护实验室的人员均经过适当培训， 准备为国家和区域对生物防护研究专业人员的需求服务。 为了实现这些目标，我们建议建立三个合作核心。设施管理 维护和运营核心（FMMO Core）负责确保设施始终可用 以满足RBL的研究和应急准备使命。BSL-3实践和劳动力 发展核心（BSL-3 PWD核心）正式确定了我们的导师-学员培训计划，以确保我们的实验室 配备了BSL-3研究专业人员，他们精通生物遏制研究专业人员。这一核心 应对像COVID-19这样迅速出现的公共卫生突发事件的反应受到限制的现实， 现有的BSL-3培训和经验丰富的研究专业人员的数量。我们的大流行防范 和响应综合研究核心（PaPR核心）响应大幅增加的要求，我们 BSL-3研究服务，组织一个综合的全方位服务BSL-3研究支持职能， 调查员需要。这些核心将协同工作，以实现CPM的使命：准备和响应 新冠肺炎疫情等突发公共卫生事件。

SUMMARY (OVERALL): The University of Louisville Regional Biocontainment Laboratory (RBL) is operated by the University Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases (CPM). The RBL is a regional resource that facilitates translational research to develop diagnostics, prognostics, therapeutics and vaccines to mitigate biodefense and emerging infectious disease threats. Our Center operates the only BSL-3 and ABSL-3 facilities currently operating in the Commonwealth of Kentucky. The CPM mandate is to prepare for and respond to public health emergencies, such as the COVID-19 pandemic. The broad, long-range objectives and goals of the University of Louisville (UofL) CPM RBL are: 1. To offer state-of-the-art research services to the regional and national biomedical research community to learn from past pandemics and biological warfare experiences and effectively predict and mitigate future emerging infectious disease threats. 2. To manage, maintain and operate the UofL RBL to serve the national and regional need for biocontainment facilities suitable for research on Risk Group 3 pathogens and other biothreats. 3. To follow a philosophy of continuous improvement in BSL-3 and ABSL-3 work practices and to ensure that all personnel who need to access BSL-3 and ABSL-3 containment laboratories are appropriately trained and prepared to serve the national and regional need for biocontainment research professionals. To achieve these aims we propose to establish three collaborative Cores. The Facilities Management Maintenance and Operations Core (FMMO Core) is responsible for ensuring that the facility is always available to meet the research and emergency preparedness mission of the RBL. The BSL-3 Practices and Workforce Development Core (BSL-3PWD Core) formalizes our mentor-mentee training plan to ensure our laboratory is staffed with BSL-3 research professionals who are proficient at biocontainment research professionals. This core responds to the reality that response to rapidly emerging public health emergencies like COVID-19 is limited by the number of available BSL-3 trained and experienced research professionals. Our Pandemic Preparedness and Response Integrated Research Core (PaPR Core) responds to the substantially increased requests for our BSL-3 research services by organizing an integrated full-service BSL-3 research support function to support investigator needs. These cores will work in unison to achieve the CPM mission: to prepare for and respond to public health emergencies like the COVID-19 pandemic.