Research Training in Natural Product Complementary and Integrative Health

项目总结/摘要 俄勒冈州州立大学（OSU）药学院成立于120年前，是美国历史最悠久的药学院之一。 自2004年博士前培训计划以来， 制药科学始于1952年。1973年由两届诺贝尔奖得主莱纳斯·鲍林创立， 坐落在最先进的莱纳斯鲍林科学中心在俄勒冈州立大学校园，莱纳斯鲍林研究所 (LPI)仍然侧重于使用微量营养素、植物化学物质和膳食补充剂来预防疾病 维护人类健康。我们的毕业生在学术界，工业界和政府中占据领导地位 在美国和全世界。从历史上看，天然产品占所有产品的一半以上。 治疗剂，今天仍然是近40%的新药的灵感。培养青年科学家， 天然产品和膳食补充剂研究的职业生涯是我们药学院的核心使命 和LPI，并将是这个培训补助金的重点。为了满足培养新一代 天然产物药物发现和膳食营养素的安全性和有效性研究专家 作为补充，我们建议建立一个新的培训补助金计划，将招收5名博士前学员 时间目前，在俄勒冈州立大学药学院或LPI没有培训补助金。我们的导师团队 包括在海洋，微生物和植物天然产品和膳食补充剂方面具有专业知识的教师， 以及天然产物基因组学，癌症治疗，化学预防，药理学，膳食补充剂， 有机合成和生物合成。我们的领导团队包括经验丰富的联合项目负责人 领导一个T32培训计划（货车Breemen博士）和经验，担任研究生课程主任， 我们的部门（马哈茂德博士）。最后，我们的培训计划将得到加强， 承诺的形式，行政支持从药学院俄勒冈州立大学，系 制药科学和LPI以及OSU研究生院的财政支持作为部分学费 弃权书

PROJECT SUMMARY/ABSTRACT Founded 120 years ago, the Oregon State University (OSU) College of Pharmacy is one of the oldest in the United States and has been a leader in natural products research since our predoctoral training program in Pharmaceutical Sciences began in 1952. Founded in 1973 by two-time Nobel Laureate Linus Pauling and housed in the state-of-the-art Linus Pauling Science Center on the OSU campus, the Linus Pauling Institute (LPI) remains focused on using micronutrients, phytochemicals and dietary supplements to prevent disease and maintain human health. Our graduates occupy leadership positions in academia, industry and government in the United States and throughout the world. Historically, natural products have accounted for over half of all therapeutic agents, and today are still the inspiration of nearly 40% of new drugs. Training young scientists for careers in natural products and dietary supplements research is a core mission of our College of Pharmacy and the LPI and will be the focus of this training grant. To address the need to train a new generation of experts in research concerning natural products drug discovery and in the safety and efficacy of dietary supplements, we propose to establish a new training grant program that will enroll 5 predoctoral trainees at a time. Currently, there is no training grant based in the OSU College of Pharmacy or the LPI. Our mentor team includes faculty with expertise in marine, microbial and botanical natural products and dietary supplements as well as natural product genomics, cancer therapy, chemoprevention, pharmacology, dietary supplements, organic synthesis, and biosynthesis. Our leadership team includes co-Program Leaders with experience leading a T32 training program (Dr. van Breemen) and experience serving as a director of graduate studies for our department (Dr. Mahmud). Finally, our training program will be enhanced by exceptional institutional commitment in the forms of administrative support from the OSU College of Pharmacy, the Department of Pharmaceutical Sciences and the LPI and financial support from the OSU Graduate School as partial tuition waivers.