Enriched environments: a multi-level integrative medicine intervention for endometriosis

项目摘要-摘要 这项资助研究的目标是开发一种基于EE的多模式干预 在该团队的动物模型中测试了范式，并测试了其在患有 子宫内膜异位症。干预行动原定于2020年1月11日开始，到 2019年12月，干预的所有后勤工作都已到位。然而，由于天然的 影响波多黎各的灾害(2020年1-2月发生的一系列地震，以及 新冠肺炎大流行)，科考队不得不做出艰难的决定推迟 开始干预。该团队考虑到了公关中的高度压力 人口将影响这项研究，因为很难区分正在进行的 自然灾害给子宫内膜异位症患者带来了生活压力。 目前，波多黎各新冠肺炎疫苗接种工作持续快速、积极推进 利率低于5%，政府已经取消了对集会和 宵禁。科学团队决定在2021年8月开始干预。在……里面 为此，该团队请求NIH免费延长，以允许 将这项研究再延长一年，该研究已获批准。然而，剩下的 资金不包括研究小组关键职位、研究协调员、 保拉·拉莫斯女士。我们在此请求额外的资金来支持这项研究 协调员加薪一年，弥补因新冠肺炎而损失的时间 相关限制。此外，我们正在请求额外资金，以支付与 干预期间预防新冠肺炎的措施。研究协调员职位 对项目的成功至关重要，因为该职位负责 参与活动的后勤，数据收集和分析，以及对学习的跟踪 提供干预的对象、场地和教练。此外，这项研究 协调员对数据录入、质量控制和分析以及 生成进度报告、演示文稿和出版物。

Project Summary-Abstract The goal of the funded study is to develop a multi-modal intervention based on the EE paradigm tested in the team's animal model and test its efficacy in women with endometriosis. The start of the intervention was set to begin January 11, 2020, and by December 2019 all logistics of the interventions were in place. However, due to natural disasters affecting Puerto Rico (a series of earthquakes in January-February 2020, and the COVID-19 pandemic), the scientific team had to make the difficult decision to postpone the start of the intervention. The team factored in that the high levels of stress in the PR population would affect the study as it would be difficult to disentangle the effect of ongoing natural disasters to the stress of living with endometriosis. Currently, vaccination for COVID-19 in Puerto Rico continue to advance rapidly, positivity rates are lower than 5%, and the government has lifted most restrictions on gatherings and curfews. The scientific team made the decision to start the intervention in August 2021. In preparation for this, the team requested an NIH no -cost extension to allow for the continuation of this study for an additional year, which was approved. However, the remaining funds do not include the salary of a key position in the study team, the Research Coordinator, Ms. Paola Ramos. We are hereby requesting additional funds to support the Research Coordinator's salary for an additional year to make up for the time lost due to COVID-19 related restrictions. In addition, we are requesting additional funds to cover costs related to measures to prevent COVID-19 during the interventions. The Research Coordinator position is crucial for the success of the project as this position is in charge of overall organization of the logistics involved in the activities, data collection and analysis, and follow-ups on study subjects, venues, and coaches delivering the interventions. In addition, the Research Coordinator contributes extensively to data entry, quality control, and analysis as well as the generation of progress reports, presentations, and publications.