Enriched environments: a multi-level integrative medicine intervention for endometriosis

丰富的环境：子宫内膜异位症的多层次综合医学干预

• 批准号: 10432531
• 负责人: IDHALIZ FLORES
• 金额: $ 6.08万
• 依托单位: PONCE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10432531
• 关键词: Affect; Animal Model; Animal Testing; COVID-19; COVID-19 pandemic; COVID-19 prevention; COVID-19 vaccination; Charge; Data; Data Analyses; Data Collection; Earthquakes; Funding; Generations; Goals; Government; Grant; Integrative Medicine; Intervention; Lifting; Logistics; Measures; Natural Disasters; Population; Positioning Attribute; Preparation; Progress Reports; Publications; Puerto Rico; Quality Control; Research; Research Support; Series; Stress; Study Subject; Testing; Time; United States National Institutes of Health; Wages; Woman; base; cost; endometriosis; environmental enrichment for laboratory animals; multi-component intervention; success

Project Summary-Abstract The goal of the funded study is to develop a multi-modal intervention based on the EE paradigm tested in the team's animal model and test its efficacy in women with endometriosis. The start of the intervention was set to begin January 11, 2020, and by December 2019 all logistics of the interventions were in place. However, due to natural disasters affecting Puerto Rico (a series of earthquakes in January-February 2020, and the COVID-19 pandemic), the scientific team had to make the difficult decision to postpone the start of the intervention. The team factored in that the high levels of stress in the PR population would affect the study as it would be difficult to disentangle the effect of ongoing natural disasters to the stress of living with endometriosis. Currently, vaccination for COVID-19 in Puerto Rico continue to advance rapidly, positivity rates are lower than 5%, and the government has lifted most restrictions on gatherings and curfews. The scientific team made the decision to start the intervention in August 2021. In preparation for this, the team requested an NIH no -cost extension to allow for the continuation of this study for an additional year, which was approved. However, the remaining funds do not include the salary of a key position in the study team, the Research Coordinator, Ms. Paola Ramos. We are hereby requesting additional funds to support the Research Coordinator's salary for an additional year to make up for the time lost due to COVID-19 related restrictions. In addition, we are requesting additional funds to cover costs related to measures to prevent COVID-19 during the interventions. The Research Coordinator position is crucial for the success of the project as this position is in charge of overall organization of the logistics involved in the activities, data collection and analysis, and follow-ups on study subjects, venues, and coaches delivering the interventions. In addition, the Research Coordinator contributes extensively to data entry, quality control, and analysis as well as the generation of progress reports, presentations, and publications.

项目摘要-摘要 资助研究的目标是开发一种基于EE的多模式干预 在该团队的动物模型中进行了测试，并测试了其在女性中的功效， 子宫内膜异位症干预的开始时间定为2020年1月11日开始， 2019年12月，所有干预措施的后勤工作都已到位。然而，由于自然 影响波多黎各的灾害（2020年1月至2月发生的一系列地震，以及 在2019冠状病毒病（COVID-19）大流行期间，科学团队不得不做出艰难的决定， 干预的开始。该团队考虑到，公关部门的高压力 人群将影响研究，因为很难区分正在进行的 自然灾害到子宫内膜异位症的压力。 目前，波多黎各的COVID-19疫苗接种工作继续快速推进， 利率低于5%，政府已经取消了对集会的大部分限制， 宵禁科学团队决定于2021年8月开始干预。在 为此，研究小组要求NIH免费延长研究时间， 本研究再延长一年，已获批准。但剩下的 资金不包括研究团队中关键职位的工资，研究协调员， 女士保拉拉莫斯。我们在此要求额外的资金，以支持研究 额外一年的协调员工资，以弥补因COVID-19而损失的时间 相关限制。此外，我们还要求提供额外资金，以支付与以下方面有关的费用： 在干预期间采取预防COVID-19的措施。研究协调员职位 对项目的成功至关重要，因为该职位负责全面组织 活动、数据收集和分析以及研究后续行动所涉及的后勤工作 主题、场地和提供干预的教练。此外，研究 协调员对数据输入、质量控制和分析以及 生成进度报告、演示文稿和出版物。

项目成果

Short treatment with antalarmin alters adrenal gland receptors in the rat model of endometriosis.

安塔拉明短期治疗会改变子宫内膜异位症大鼠模型中的肾上腺受体。

• DOI: 10.1371/journal.pone.0227456
• 发表时间: 2020
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Torres-Reverón,Annelyn;Rana,Maahrose;Gorabi,Varesh;Rivera-Lopez,LeslieL;Appleyard,CarolineB
• 通讯作者: Appleyard,CarolineB

Efficacy of an environmental enrichment intervention for endometriosis: a pilot study.

环境富集干预对子宫内膜异位症的功效：一项试点研究。

• DOI: 10.3389/fpsyg.2023.1225790
• 发表时间: 2023
• 期刊: FRONTIERS IN PSYCHOLOGY
• 影响因子: 3.8
• 作者: De Hoyos, Grace;Ramos-Sostre, Darlenne;Torres-Reveron, Annelyn;Barros-Cartagena, Barbara;Lopez-Rodriguez, Veronica;Nieves-Vazquez, Cristina;Santiago-Saavedra, Fanny;Appleyard, Caroline B;Castro, Eida M;Flores, Idhaliz
• 通讯作者: Flores, Idhaliz

Feasibility and acceptability of an adapted environmental enrichment intervention for endometriosis: A pilot study.

• DOI: 10.3389/fgwh.2022.1058559
• 发表时间: 2022
• 期刊: FRONTIERS IN GLOBAL WOMENS HEALTH
• 作者: Nieves-Vazquez, Cristina I.;Detres-Marquez, Amanda C.;Torres-Reveron, Annelyn;Appleyard, Caroline B.;Llorens-De Jesus, Astrid P.;Resto, Ivana N.;Lopez-Rodriguez, Veronica;Ramos-Echevarria, Paola M.;Castro, Eida M.;Flores, Idhaliz
• 通讯作者: Flores, Idhaliz

The Link Between Stress and Endometriosis: from Animal Models to the Clinical Scenario.

• DOI: 10.1007/s43032-020-00205-7
• 发表时间: 2020-09
• 期刊: REPRODUCTIVE SCIENCES
• 影响因子: 2.9
• 作者: Appleyard, Caroline B.;Flores, Idhaliz;Torres-Reveron, Annelyn
• 通讯作者: Torres-Reveron, Annelyn