Research Training in Natural Product Complementary and Integrative Health - Diversity Supplement to T32 Predoctoral Training Grant

天然产品补充和综合健康研究培训 - T32 博士前培训补助金的多样性补充

• 批准号: 10757578
• 负责人: TAIFO MAHMUD
• 金额: $ 4.25万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10757578
• 关键词: Complementary Health; Grant; Integrative Medicine; Natural Products; Research Training; Training; pre-doctoral

PROJECT SUMMARY/ABSTRACT Training young scientists for careers in natural products and dietary supplements research is a core mission of the Pharmaceutical Sciences Ph.D. program at the Oregon State University College of Pharmacy and is the focus of this predoctoral training grant. To address the need to train a new generation of experts in research concerning natural products drug discovery and in the safety and efficacy of dietary supplements, this T32 training grant enrolls 5 predoctoral trainees at a time. Our mentor team includes faculty with expertise in marine, microbial and botanical natural products and dietary supplements as well as natural product genomics, cancer therapy, chemoprevention, pharmacology, dietary supplements, and biosynthesis. Our leadership team includes co-Program Leaders with experience leading a T32 training program (Dr. van Breemen) and experience serving as a director of graduate studies for our department (Dr. Mahmud). In response to the need to enrich the diversity of pipeline of natural products scientists, we recruited two Hispanic/Latina graduate students who joined our Ph.D. program during the Fall Term 2022. One of these students filled a T32 slot that opened upon the graduation of one of our trainees. We are requesting a 12-month diversity supplement to temporarily support the other graduate student from an under-represented group in the biomedical sciences. This supplement will support her until another T32 slot becomes available. Currently, this other Hispanic/Latino student is being supported by the OSU College of Pharmacy.

项目摘要/摘要 培养年轻科学家从事天然产品和膳食补充剂研究是 俄勒冈州立大学药学院的药学博士项目，是 这笔博士前培训补助金的重点。满足培养新一代研究专家的需要 关于天然产品的药物发现和膳食补充剂的安全性和有效性，本T32 培训补助金一次招收5名博士前实习生。我们的导师团队包括具有以下专业知识的教员 海洋、微生物和植物天然产品和膳食补充剂以及天然产品基因组学， 癌症治疗、化学预防、药理学、膳食补充剂和生物合成。我们的领导团队 包括具有领导T32培训计划经验的联合计划负责人(van Breeman博士)和 担任我们系研究生课程主任的经历(马哈茂德博士)。为了回应这一需求 为了丰富天然产品研发渠道的多样性，我们招募了两名西班牙裔/拉丁裔毕业生 在2022年秋季学期参加我们博士项目的学生。其中一名学生填补了T32的空缺 是在我们的一位实习生毕业时开始的。我们正在申请为期12个月的多样性补充 暂时资助来自生物医学科学方面代表性不足的另一名研究生。 这一补充将支持她，直到另一个T32插槽可用。目前，另一名西班牙裔/拉丁裔 这名学生得到俄亥俄州立大学药学院的支持。

项目成果

Brodifacoum pharmacokinetics in acute human poisoning: implications for estimating duration of vitamin K therapy.

• DOI: 10.1080/24734306.2021.1887637
• 发表时间: 2021
• 期刊: Toxicology communications
• 作者: Nosal DG;van Breemen RB;Haffner JW;Rubinstein I;Feinstein DL
• 通讯作者: Feinstein DL

Inhaled synthetic cannabinoids laced with long-acting anticoagulant rodenticides: A clear and present worldwide danger.

吸入的合成大麻素与长效抗凝啮齿动物相处：一种清晰而当前的危险。

• DOI: 10.1080/24734306.2022.2025690
• 发表时间: 2022
• 期刊: TOXICOLOGY COMMUNICATIONS
• 作者: Feinstein, Douglas L.;Hafner, John;van Breemen, Richard;Rubinstein, Israel
• 通讯作者: Rubinstein, Israel

Advances in Magnetic Microbead Affinity Selection Screening: Discovery of Natural Ligands to the SARS-CoV-2 Spike Protein.

• DOI: 10.1021/jasms.1c00318
• 发表时间: 2022-01-05
• 期刊: JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
• 影响因子: 3.2
• 作者: Muchiri, Ruth N.;Kibitel, James;Redick, Margaret A.;van Breemen, Richard B.
• 通讯作者: van Breemen, Richard B.

Chiral liquid chromatography-tandem mass spectrometry analysis of superwarfarin rodenticide stereoisomers - Bromadiolone, difenacoum and brodifacoum - In human plasma.

• DOI: 10.1016/j.jchromb.2021.122529
• 发表时间: 2021-02-15
• 期刊: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
• 作者: Nosal DG;Feinstein DL;van Breemen RB
• 通讯作者: van Breemen RB

New species and new combinations in the genus Paraisaria (Hypocreales, Ophiocordycipitaceae) from the U.S.A., supported by polyphasic analysis.

• DOI: 10.3897/mycokeys.100.110959
• 发表时间: 2023
• 期刊: MycoKeys
• 影响因子: 3.3
• 作者: Tehan RM;Dooley CB;Barge EG;McPhail KL;Spatafora JW
• 通讯作者: Spatafora JW