Controlling Arbovirus Transmission: PopulationSuppression and Virus-Induced Mosquito Death
控制虫媒病毒传播:种群抑制和病毒引起的蚊子死亡
基本信息
- 批准号:10529281
- 负责人:
- 金额:$ 15.15万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-12-13 至 2024-11-30
- 项目状态:已结题
- 来源:
- 关键词:AdolescentAdultAedesAedes aegypti genomeAmericasAntibioticsArbovirusesAutomobile DrivingBrazilBreedingCell Culture SystemCessation of lifeChemicalsContractsCountryCulicidaeDengueDengue FeverDengue VirusDevelopmentDisease OutbreaksEmbryoEnvironmental ImpactEpidemicFemaleFertilityFlavivirusFloridaGenesGoalsHomingHumanInfectionInsectaInsecticidesIntellectual PropertyLarvaLocationMarketingModelingMonitorMosquito ControlNeurotoxinsPartner in relationshipPeptide HydrolasesPeptidesPhenotypePopulationPopulation ControlPopulations at RiskPrivatizationProcessProcess AssessmentProductionProteinsPublic HealthPupaRecoveryReportingResistanceResourcesRibosomal DNARiskRisk AssessmentSeriesSiteSourceSterilitySystemTechnologyTestingTestisTetracycline ControlTetracyclinesTexasTimeTransgenesTransgenic OrganismsUniversitiesViralVirusVirus ReplicationWorkYellow FeverZIKAZika Virusarboviral diseasecosteggendonucleaseexperiencefitnessimprovedinnovationmalaria mosquitomalemortalitymosquito-bornenegative affectnew technologynext generationnucleasepathogenprogramssperm cellsperm viabilitysuccesssurvivorshiptransmission blockingtransmission processvaccine accessvectorvector controlvector mosquitoviral transmissionzika fever
项目摘要
Abstract:
Aedes mosquitoes continue to transmit viruses such as dengue, Zika and yellow fever, with much of the world’s
population at risk. This is particularly true in Brazil, where dengue epidemics are continuous, where the Zika
epidemic hit hardest, and where urban yellow fever continually threatens to re-emerge. In order to establish new
vector control strategies, Brazil has pioneered the testing and approval of a new strategy called Release of
Insects with Dominant Lethality (RIDL), based on the intellectual property of Oxitec, LLC. RIDL relies on the
mass release of male Ae. aegypti mosquitoes; mating with wild females results in progeny that die as late larvae
or pupae. While field trials have demonstrated successful population suppression, obstacles to the widespread
use of the technology include difficulty in monitoring, competitiveness of released males, cost of antibiotic used
to suppress the lethal phenotype at factory scale, and rapid recovery of the mosquito population once releases
cease. Modeling suggests that the release of pathogen-resistant mosquitoes following a population suppression
campaign can result in the establishment of the resistance phenotype, a so called “reduce and replace” approach
that could more permanently block transmission. To develop a reduce and replace system for the control of
dengue/Zika transmission, a transgenic conditional sterility system in Ae. aegypti will be established (Aim 1).
Unlike current approaches where factory-scale rearing of released males must occur in the presence of
tetracycline, such an approach necessitates antibiotic use only in the egg production colony, substantially
reducing costs. Early embryonic lethality will in turn simplify monitoring approaches. This project will also develop
a death-upon-infection strain of Ae. aegypti that will provide broad resistance across all mosquito-borne
flaviviruses (Aim 2). This innovative approach takes advantage of progress already made in navigating
transgenic Ae. aegypti through the regulatory process in Brazil, and the products to be developed are anticipated
to directly enter the risk assessment process for field-based testing at the conclusion of this work.
摘要:
伊蚊继续传播登革热、寨卡和黄热病等病毒,世界上大部分地区的
人口处于危险之中。在巴西尤其如此,那里的登革热疫情持续不断,
这一流行病受到的打击最严重,城市黄热病不断有重新出现的危险。以建立新
在病媒控制战略方面,巴西率先测试和批准了一项新战略,
基于Oxitec,LLC知识产权的显性致死性昆虫(RIDL)。RIDL依赖于
大量释放雄性Ae.埃及蚊;与野生雌蚊交配产生的后代作为晚期幼虫死亡
或者是脓包虽然田间试验已经证明了成功的种群抑制,但广泛传播的障碍
该技术的使用包括监测困难、释放的男性的竞争力、使用抗生素的成本
在工厂规模上抑制致死表型,并在释放后迅速恢复蚊子种群
停止。模型表明,释放病原体抗性蚊子后,人口抑制
运动可以导致抗性表型的建立,即所谓的“减少和替换”方法
可以更持久地阻断病毒传播开发一个减少和替换系统,用于控制
登革热/寨卡病毒传播,Ae.将建立埃及(目标1)。
不像目前的方法,其中释放的雄性的工厂规模饲养必须在存在的情况下发生,
四环素,这种方法需要抗生素的使用,只有在鸡蛋生产的殖民地,
降低成本。早期胚胎致死性反过来将简化监测方法。该项目还将开发
一种感染后死亡的Ae病毒埃及,将提供广泛的抵抗所有蚊子传播的
黄病毒(Aim 2)。这种创新的方法利用了在导航方面已经取得的进展,
转基因Ae.埃及通过巴西的监管程序,预计将开发的产品
在这项工作结束时直接进入基于现场的测试的风险评估过程。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Zach N. Adelman其他文献
emAedes aegypti/em sialokinin facilitates mosquito blood feeding and modulates host immunity and vascular biology
- DOI:
10.1016/j.celrep.2022.110648 - 发表时间:
2022-04-12 - 期刊:
- 影响因子:6.900
- 作者:
Ines Martin-Martin;Paola Carolina Valenzuela Leon;Laura Amo;Gaurav Shrivastava;Eva Iniguez;Azadeh Aryan;Steven Brooks;Bianca B. Kojin;Adeline E. Williams;Silvia Bolland;Hans Ackerman;Zach N. Adelman;Eric Calvo - 通讯作者:
Eric Calvo
emAedes aegypti/em D7 long salivary proteins modulate blood feeding and parasite infection
埃及伊蚊 D7 长唾液蛋白调节吸血和寄生虫感染
- DOI:
10.1128/mbio.02289-23 - 发表时间:
2023-11-10 - 期刊:
- 影响因子:4.700
- 作者:
Ines Martin-Martin;Bianca Burini Kojin;Azadeh Aryan;Adeline E. Williams;Alvaro Molina-Cruz;Paola Carolina Valenzuela-Leon;Gaurav Shrivastava;Karina Botello;Mahnaz Minai;Zach N. Adelman;Eric Calvo;Bruno Lemaitre - 通讯作者:
Bruno Lemaitre
Zach N. Adelman的其他文献
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{{ truncateString('Zach N. Adelman', 18)}}的其他基金
Self-eliminating strategy to control gene drive
控制基因驱动的自我消除策略
- 批准号:
10401434 - 财政年份:2020
- 资助金额:
$ 15.15万 - 项目类别:
Self-eliminating strategy to control gene drive
控制基因驱动的自我消除策略
- 批准号:
10202464 - 财政年份:2020
- 资助金额:
$ 15.15万 - 项目类别:
The role of the circadian clock in the behavior of the malaria mosquito Anopheles coluzzii
生物钟在疟疾蚊子按蚊行为中的作用
- 批准号:
10083702 - 财政年份:2020
- 资助金额:
$ 15.15万 - 项目类别:
Self-eliminating strategy to control gene drive
控制基因驱动的自我消除策略
- 批准号:
10625308 - 财政年份:2020
- 资助金额:
$ 15.15万 - 项目类别:
Controlling Arbovirus Transmission: PopulationSuppression and Virus-Induced Mosquito Death
控制虫媒病毒传播:种群抑制和病毒引起的蚊子死亡
- 批准号:
9890195 - 财政年份:2019
- 资助金额:
$ 15.15万 - 项目类别:
Controlling Arbovirus Transmission: PopulationSuppression and Virus-Induced Mosquito Death
控制虫媒病毒传播:种群抑制和病毒引起的蚊子死亡
- 批准号:
10526660 - 财政年份:2019
- 资助金额:
$ 15.15万 - 项目类别:
Controlling Arbovirus Transmission: PopulationSuppression and Virus-Induced Mosquito Death
控制虫媒病毒传播:种群抑制和病毒引起的蚊子死亡
- 批准号:
10306388 - 财政年份:2019
- 资助金额:
$ 15.15万 - 项目类别:
Controlling Arbovirus Transmission: PopulationSuppression and Virus-Induced Mosquito Death
控制虫媒病毒传播:种群抑制和病毒引起的蚊子死亡
- 批准号:
10721405 - 财政年份:2019
- 资助金额:
$ 15.15万 - 项目类别:
Controlling Arbovirus Transmission: Population Suppression and Virus-Induced Mosquito Death
控制虫媒病毒传播:种群抑制和病毒引起的蚊子死亡
- 批准号:
10328078 - 财政年份:2019
- 资助金额:
$ 15.15万 - 项目类别:
DNA repair pathway choice and significance in targeted genome editing of Aedes aegypti
DNA修复途径的选择及其在埃及伊蚊基因组靶向编辑中的意义
- 批准号:
10318160 - 财政年份:2018
- 资助金额:
$ 15.15万 - 项目类别:
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