Reinvigorating HIV Prevention and Care for People Who Use Drugs: Accelerating Progress and Sustaining Gains in the Midst of Societal Disruption

重振艾滋病毒预防和对吸毒者的护理：在社会混乱中加速进展并保持成果

• 批准号: 10528213
• 负责人: Don C Des Jarlais
• 金额: $ 150.61万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10528213
• 关键词: AIDS prevention; Acceleration; Address; Behavioral; Biomedical Research; COVID-19; COVID-19 pandemic effects; Caring; Cities; Collaborations; Communities; Community Health; Continuity of Patient Care; County; Diagnosis; Discipline; Disease Outbreaks; Disease Outcome; Disparity; Drug Industry; Drug usage; Drug user; Ensure; Environment; Epidemic; Epidemiology; Event; Funding; Future; Generations; Goals; HIV; HIV Infections; HIV Seronegativity; HIV Seropositivity; HIV diagnosis; HIV/HCV; Harm Reduction; Health; Hepatitis C virus; Heroin Users; Heterosexuals; Homelessness; Hurricane; Incidence; Income; Indiana; Individual; Inequality; Infectious Disease Epidemiology; Infrastructure; Injecting drug user; International; Interruption; Knowledge; Leadership; Mentors; Methodology; Methods; Morbidity - disease rate; New York; New York City; Overdose; Pattern; Personal Satisfaction; Phase; Pilot Projects; Policy Maker; Poverty; Predisposition; Prevalence; Prevention; Process; Productivity; Public Health; Recording of previous events; Research; Research Methodology; Research Personnel; Research Support; Resources; Risk; Role; Science; Scientific Advances and Accomplishments; Scientist; Sentinel; Services; Signal Transduction; Stress; Substance Use Disorder; Syringes; Testing; Trauma; Underrepresented Populations; Unemployment; United States National Institutes of Health; Viral; Weather; base; disorder prevention; drug market; experience; improved; innovation; member; method development; mortality; new pandemic; opioid epidemic; overdose prevention; pandemic disease; people of color; pre-exposure prophylaxis; service providers; sexual minority men; skills; social; substance use; substance user; synergism; theories; transgender women; transmission process; treatment as prevention; trend; uptake

Project Summary/Abstract – Overall – Center for Drug Use and HIV Research (CDUHR) Biomedical advances in HIV prevention and care, principally pre-exposure prophylaxis (PrEP) and treatment as prevention, led to optimistic predictions and plans to bring HIV under control by 2020. For people who use drugs (PWUD) in NYC, the US, and abroad, it is unlikely that the WHO 90-90-90 goals (90% diagnosed, 90% of diagnosed in care, and 90% of those in care virally suppressed) will be met in the near future. In the US, there have been more than a dozen additional HIV outbreaks among people who inject drugs (PWID) since the sentinel HIV outbreak in Indiana PWID in 2014. In NYC, 64% of PWUD living with HIV are viremic, and mortality rates in HIV-positive PWID in NYC are twice as high as in sexual minority men and heterosexuals living with HIV. PrEP uptake among PWUD is very low (0-3% in the US), even in the midst of outbreaks when it is needed most. After a decade of declines, new HIV diagnoses in US PWID have been increasing 4% per year since 2012. COVID-19 has increased unemployment, homelessness, and substance use across the nation, and is threatening gains that have been made toward ending HIV among PWUD. Thus, our Center for Drug Use and HIV Research has chosen the theme, “Reinvigorating HIV prevention and care for people who use drugs: Accelerating progress and sustaining gains in the midst of societal disruption.” To achieve this, we will lead the field and support our investigators to: 1) understand how large- scale societal changes may undermine HIV prevention and treatment for PWUD, 2) gain knowledge and skills to carry out studies that address the specific needs of PWUD at elevated risk of HIV infection, morbidity and mortality including PWID, sexual minority men, transgender women, and people of color who use drugs, to reduce persistent and widening disparities, and 3) engage with community members to improve the relevance and impact of the knowledge generated. We are committed to supporting new and early stage investigators (new/ESI), especially those who are underrepresented in NIH funding, to achieve their potential as productive and successful scientists. We will achieve these aims through four Cores – an Administrative Core, the Pilot Projects and Mentoring Core, and two Research Support Cores – the Infectious Disease Epidemiology and Social-Behavioral Theory Core, and the Transdisciplinary Research Methods Core. These Cores support our research base and affiliated investigators to conduct cutting-edge science and enhance synergy across investigators from multiple disciplines, thereby leading to contributions to the field that are beyond what the individual projects could have achieved. Our theme and aims build upon many years of research experience and collaboration, broad methodological and theoretical expertise and innovation, and engagement with community and public health partners locally, regionally, nationally and internationally.

项目摘要/摘要-总体-药物使用和艾滋病毒研究中心(CDUHR) 艾滋病毒预防和护理方面的生物医学进展，主要是暴露前预防(PrEP)和 治疗作为预防导致了乐观的预测和到2020年将艾滋病毒控制在可控范围内的计划。对于人们来说 在纽约、美国和国外使用药物(PWUD)的人，不太可能达到世卫组织的90-90-90目标(90% 确诊的，90%的确诊在护理中，90%的护理中的人)将在不久的将来得到满足 未来。在美国，在注射毒品的人中又爆发了十几起艾滋病毒疫情 (PWID)自2014年印第安纳州哨兵艾滋病毒爆发以来。在纽约市，携带艾滋病毒的PWUD患者中 病毒感染，纽约市HIV阳性PWID的死亡率是性少数族裔男性的两倍 携带艾滋病毒的异性恋患者。PWUD中的PREP摄取率非常低(在美国为0-3%)，即使在 在最需要的时候爆发。在经历了十年的下降之后，美国PWID新诊断的艾滋病毒病例 自2012年以来每年增长4%。新冠肺炎增加了失业率、无家可归者和物质 在全国范围内使用，并威胁到在结束PWUD中的艾滋病毒方面已经取得的成果。 因此，我们的药物使用和艾滋病毒研究中心选择了主题：“振兴艾滋病毒预防 和对吸毒者的关怀：在社会变革中加速进步和持续进步 颠覆性的。为了实现这一目标，我们将领导现场并支持我们的调查人员：1)了解- 大规模的社会变化可能会破坏对PWUD的艾滋病毒预防和治疗，2)获得知识和技能 进行研究，以满足艾滋病毒感染风险、发病率和死亡率较高的PWUD的特殊需求 死亡率包括PWID、性少数族裔男性、变性人和有色人种吸毒者 减少持续和不断扩大的差距，以及3)与社区成员接触，以提高相关性 以及所产生的知识的影响。我们致力于支持新的和早期的调查人员 (新的/ESI)，特别是那些在NIH资金中任职人数不足的人，以实现其生产潜力 以及成功的科学家。我们将通过四个核心来实现这些目标--行政核心、试点 项目和指导核心，以及两个研究支持核心-传染病流行病学和 社会行为理论核心和跨学科研究方法核心。这些核心支持我们的 研究基地和附属研究人员开展尖端科学，增强跨领域协同效应 来自多个学科的研究人员，从而导致对该领域的贡献超出 个别项目本可以实现的。我们的主题和目标建立在多年的研究经验基础上 和协作，广泛的方法和理论专业知识和创新，以及与 地方、区域、国家和国际的社区和公共卫生合作伙伴。

项目成果

Presence of Content Appealing to Youth on Cannabis-Infused Edibles Packaging.

• DOI: 10.1080/10826084.2022.2069268
• 发表时间: 2022
• 期刊: SUBSTANCE USE & MISUSE
• 影响因子: 2
• 作者: Tan, Andy S. L.;Weinreich, Erica;Padon, Alisa;Sanchez, Mirtala;Snyder, Kyle M.;Vasilyeva, Anna;Sandh, Simon;Goldmann, Emily;Goodman, Melody;Ompad, Danielle C.
• 通讯作者: Ompad, Danielle C.

Willingness to provide a hair sample for drug testing among electronic dance music party attendees.

• DOI: 10.1080/08897077.2018.1469106
• 发表时间: 2019
• 期刊: Substance abuse
• 影响因子: 3.5
• 作者: Palamar JJ;Salomone A;Cleland CM;Sherman S
• 通讯作者: Sherman S

Sex Practices by HIV Awareness and Engagement in the Continuum of Care Among MSM: A National HIV Behavioral Surveillance Analysis in 21 U.S. Cities.

• DOI: 10.1007/s10461-017-1966-4
• 发表时间: 2018-03
• 期刊: AIDS and behavior
• 影响因子: 4.4
• 作者: Whitham HK;Sansom SL;Wejnert C;Finlayson T;Huang YA;An Q;Paz-Bailey G;NHBS Study Group
• 通讯作者: NHBS Study Group

Preexposure prophylaxis strategies for African-American women affected by mass incarceration.

受大规模监禁影响的非裔美国妇女的暴露前预防策略。

• DOI: 10.1097/qad.0000000000002749
• 发表时间: 2021-03-01
• 期刊: AIDS (London, England)
• 作者: Adams JW;Khan MR;Bessey SE;Friedman SR;McMahon JM;Lurie MN;Galea S;Marshall BDL
• 通讯作者: Marshall BDL

National income inequality and declining GDP growth rates are associated with increases in HIV diagnoses among people who inject drugs in Europe: a panel data analysis.

• DOI: 10.1371/journal.pone.0122367
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Nikolopoulos GK;Fotiou A;Kanavou E;Richardson C;Detsis M;Pharris A;Suk JE;Semenza JC;Costa-Storti C;Paraskevis D;Sypsa V;Malliori MM;Friedman SR;Hatzakis A
• 通讯作者: Hatzakis A