Autoclave for DMU Shared Biomedical Research Facility

摘要 得梅因大学的动物研究环境包括一个强大的NIH团队 为调查人员提供资金，配备优良的设备和工作人员支持，安置在现代动物护理中心 设施。目前实验能力的一个显著弱点是我们13岁的孩子 连接到独立但集成了50年的旧锅炉(不再是 生产)和净水系统。这台集成的旧设备经常坏掉 发生故障，需要维修，导致意外支出和动物饲养延误 利用研究。由于年龄和条件的原因，这种故障经常发生 现有的高压灭菌器。高压灭菌是最有效、最可靠的实验室灭菌方法 材料。高压灭菌器是一种不可或缺的成熟的主流技术 普遍存在于生物医学设施中，用于在实验中使用前对设备/产品进行消毒 或在处置前使物品不具传染性。尽管它对NIH的研究很重要，但我们的 目前的高压灭菌器，虽然维护良好，大量使用，但已经跟不上当前的状态- 为我们的动物和普通生物医学研究提供最先进的灵敏度、可靠性和及时性。 因此，我们请求资金购买新的高效集成蒸汽灭菌器(高压灭菌器)- 一种集成系统，包括微电脑控制的蒸汽灭菌器、蒸汽锅炉、 节水系统和控制系统-允许可靠地对动物和 与生物医学相关的研究工具/材料，以支持我们的主要用户和次要用户 对这项技术的需求。现代化的集成高压灭菌器将支持我们确保高效 工作流程以及安全和无污染的间隔室和研究环境。一个 在过去13年中建立了持续的大量使用记录，经常 来自许多NIH和外部资助的生物医学研究人员社区的出版物和 在得梅因大学校园进行的有指导的学生研究和培训将确保 新的集成蒸汽灭菌器将在研究生产力方面为自己买单。

Abstract The animal research environment at Des Moines University includes a strong group of NIH funded investigators with excellent equipment and staff support housed in a modern animal care facility. A significant weakness of the current experimental capabilities is our 13-year-old autoclave that is connected to a standalone but integrated 50-yr old boiler (no longer in production) and a water purification system. This integrated old equipment frequently breaks down and requires repairs, causing unanticipated expenditures and delays in conducting animal use research. Such breakdowns occur frequently because of the age and condition of the existing autoclave. Autoclaving is the most effective and reliable means of sterilizing laboratory materials. Autoclaves are an indispensable well-established mainstream technology that is used ubiquitously in biomedical facilities to sterilize equipment/products before use in an experiment or to render items non-infectious before disposal. Despite its importance to NIH research, our current autoclave, while well maintained and heavily used, has lost pace with the current state- of-the-art in sensitivity, reliability and timeliness for our animal and general biomedical research. We thereby request funds to purchase a new efficient integrated Steam Sterilizer (autoclave) - an integrated system that includes a microcomputer-controlled steam sterilizer, a steam boiler, a water saving system and a control system - to allow for reliable sterilization of animal and biomedical related research tools/materials to support our Major and Minor users that have a need for this technology. A modern integrated autoclave will support us in ensuring efficient workflows as well as a safe and contamination free vivarium and research environment. An established sustained track record of heavy use over the last thirteen years, frequent publications from the many NIH and externally funded biomedical researcher community and mentored student research and training on Des Moines University’s campus will ensure that the new integrated Steam Sterilizer will pay for itself in research productivity.