Replacement Tunnel Washer/Bedding Dispenser for Innovative Investigations

用于创新调查的替换隧道式洗衣机/寝具分配器

• 批准号: 10533554
• 负责人: Steven M. Niemi
• 金额: $ 28.33万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10533554
• 关键词: Animal Experimentation; Animal Housing; Animal Welfare; Animals; Applications Grants; Benign; Biomedical Research; Boston; Breeding; Calendar; Capital; Chemicals; Colorectal Cancer; Communities; Consumption; Data; Detergents; Dimensions; Discipline; Embryonic Development; Ensure; Environment; Equipment; Faculty; Failure; Frequencies; Funding; Health; Heart failure; Human Resources; IACUC; Industrialization; Intention; Investigation; Laboratories; Laboratory Animals; Laboratory mice; Maintenance; Mechanics; Medical; Memory; Methods; Monitor; Motor; Mus; Natural Immunity; Obesity; Opiate Addiction; Osteogenesis; Outcome; Patients; Performance; Peripheral; Phenotype; Play; Preparation; Principal Investigator; Production; Protocols documentation; Request for Proposals; Research; Research Personnel; Risk; Rodent; Role; Rubber; Safety; Sanitation; Schedule; Science; Scientist; Sepsis; Services; Skin Cancer; Statistical Data Interpretation; System; Temperature; Testing; Time; Traumatic Brain Injury; United States National Institutes of Health; Universities; Variant; Water; acute pancreatitis; animal care; base; cost; design; expectation; experience; experimental study; improved; innovation; medical schools; novel; operation; programs; repaired; sensor; wasting; welfare

Project Summary/Abstract This proposal requests funds to purchase a new tunnel washer with integrated bedding dispenser for processing laboratory rodent cages and other husbandry supplies. This unit is a central component of a vivarium on our medical campus that currently houses 3200 cages to perform breeding and maintenance of conventional and genetically modified mice currently for 43 Principal Investigators and 46 IACUC protocols, supported by current research funding totaling $107.8M for Boston University Medical School faculty alone (of which $84.8M is provided by NIH). The research for which these animals are intended comprise biomedical research disciplines as varied as memory, neuromotor control, innate immunity and sepsis, skin or colorectal cancer, bone formation, opioid addiction, heart failure, embryogenesis, obesity, traumatic brain injury, and acute pancreatitis, to mention a few. This integrated equipment unit will replace an older tunnel washer/bedding dispenser prone to increasingly frequent breakdowns and repairs. In addition to providing a reliable and more energy-efficient upgrade, the replacement unit will facilitate testing innovative cage processing to improve how this laboratory mouse colony (and by example, possibly others) is managed. Operational enhancements to be evaluated with the new unit include: (1) optimizing rather than maximizing batches of cages and cage peripherals via a downstream “pull” system of demand, for more efficient throughput for the entire cage processing sequence; (2) using water temperatures cooler than the standard 180 degree F for wash and rinse cycles to provide a more comfortable working environment and reduce energy consumption further; (3) reducing or eliminating reliance on chemical detergents for more environmentally benign effluent; (4) evaluating sensors installed in critical mechanical components to monitor wear and tear and permit condition-based maintenance (known as “CBM” in high performance machinery jargon) that may identify looming parts failures or avoid unnecessary machine service calls from calendar- driven maintenance programs; (5) switching types of bedding or other substrates easily to match the need of a given mouse line or phenotype for better production of litters and their survival; (6) replacing scheduled cage changes with changes based solely on intra-cage conditions to reduce waste and optimize animal comfort. All these potential variations and others begin with the requirement to create no additional risk to animals, science, or personnel and no net increase in operational expenses.

项目总结/摘要 该提案要求提供资金，用于购买一台新的隧道式洗衣机， 加工实验室啮齿动物笼和其他饲养用品。该单位是一个核心组成部分， 在我们的医学校园，目前拥有3200笼进行繁殖和维护的动物园 常规和遗传修饰小鼠目前用于43个主要研究者和46个IACUC方案， 由目前的研究资金支持，仅波士顿大学医学院的教师就获得了总计1.078亿美元的研究资金（ 其中8480万美元由NIH提供）。这些动物预期用于的研究包括生物医学 研究学科多样，如记忆，神经运动控制，先天免疫和败血症，皮肤或结直肠 癌症、骨形成、阿片成瘾、心力衰竭、胚胎发育、肥胖、创伤性脑损伤，以及 急性胰腺炎，举几个例子。这个集成设备单元将取代旧隧道 洗衣机/床上用品分配器易于越来越频繁地发生故障和维修。除了提供 可靠性和更节能的升级，更换单位将便于测试创新笼 处理以改进如何管理该实验室小鼠群体（以及例如，可能的其他群体）。 新单位评估的业务改进包括：（1）优化而不是最大化 通过下游需求“拉动”系统批量生产保持架和保持架外围设备， 整个笼处理序列的吞吐量;（2）使用比标准更低的水温 180华氏度的洗涤和冲洗循环，以提供更舒适的工作环境， （3）减少或消除对化学洗涤剂的依赖， 环境友好的废水;（4）评估安装在关键机械部件中的传感器，以监测 磨损和允许基于状态的维护（在高性能机械中称为“CBM 术语），可以识别迫在眉睫的零件故障或避免不必要的机器服务呼叫，从日历- 驱动的维护程序;（5）切换类型的床上用品或其他基板容易，以满足需要的一个 给予小鼠品系或表型以更好地生产窝仔和它们的存活;（6）更换预定的笼 仅根据笼内条件进行变更，以减少浪费并优化动物舒适度。所有 这些潜在的变化和其他变化开始要求不对动物产生额外的风险， 科学，或人员，没有净增加的业务费用。