Expanding data from diverse cohorts in the AD Knowledge Portal

在 AD 知识门户中扩展来自不同群体的数据

• 批准号: 10531318
• 负责人: ANNA K GREENWOOD
• 金额: $ 16.85万
• 依托单位: SAGE BIONETWORKS
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10531318
• 关键词: Accelerated Phase; Alzheimer' s Disease; Cells; Data; Data Analytics; Data Set; Disease; FAIR principles; Funding; Gene Expression; Goals; Grant; Individual; Knowledge Portal; Medicine; Molecular; Parents; Peripheral; Research; Resolution; Sampling; Signal Transduction; Systems Biology; Therapeutic; United States National Institutes of Health; Validation; cohort; data sharing; diverse data; immunosenescence; open data; pre-clinical; proteomic signature; racial and ethnic; racial diversity; repository

Abstract This supplement will expand the AD Knowledge Portal (adknowledeportal.org) by incorporating new data being generated by a high-value set of projects that are using complementary approaches to characterize the molecular underpinnings of disease in individuals with AD from diverse racial and ethnic backgrounds. Three projects that are funded as part of the second phase of the Accelerating Medicines Partnership in Alzhiemer's disease (AMP-AD 2.0) are generating new datasets to extend the discoveries of the parent AMP-AD grants. These projects have a primary focus on diverse samples, and are examining gene expression at single-cell resolution, evaluating peripheral proteomic signatures, and characterizing signals of immunosenescence. We will support dissemination of these valuable research assets through the AD Knowledge Portal , which serves as an NIH designated repository to support the NIA's strategic goal to propagate data sharing under FAIR principles and to promote open science.

摘要 本补充材料将通过纳入以下新数据来扩展AD知识门户网站（adknowledeportal.org）： 由一组高价值的项目产生，这些项目使用互补方法来描述 来自不同种族和民族背景的AD患者疾病的分子基础。三 作为Alzhiemer加速药物伙伴关系第二阶段的一部分资助的项目 疾病（AMP-AD 2.0）正在生成新的数据集，以扩展父AMP-AD赠款的发现。 这些项目主要关注不同的样本，并在单细胞中检测基因表达。 分辨率，评估外周蛋白质组特征，并表征免疫衰老的信号。我们 将支持通过AD知识门户传播这些宝贵的研究资产， 作为NIH指定的存储库，以支持NIA在FAIR下传播数据共享的战略目标 原则和促进开放科学。