Expanding data from diverse cohorts in the AD Knowledge Portal

摘要 本附录将通过整合新的数据来扩展AD知识门户(adkendeportal.org) 由一组高价值的项目生成，这些项目使用互补的方法来表征 来自不同种族和民族背景的AD患者的疾病的分子基础。三 作为阿尔茨海默病加速药物伙伴关系第二阶段的一部分而资助的项目 疾病(AMP-AD 2.0)正在生成新的数据集，以扩展父代AMP-AD赠款的发现。 这些项目主要集中在不同的样本上，并正在检测单细胞的基因表达 分辨率，评估外周蛋白质组特征，并表征免疫衰老信号。我们 将通过AD知识门户支持这些有价值的研究资产的传播，该门户提供 作为NIH指定的存储库，以支持NIA在公平条件下促进数据共享的战略目标 原则和促进开放科学。

Abstract This supplement will expand the AD Knowledge Portal (adknowledeportal.org) by incorporating new data being generated by a high-value set of projects that are using complementary approaches to characterize the molecular underpinnings of disease in individuals with AD from diverse racial and ethnic backgrounds. Three projects that are funded as part of the second phase of the Accelerating Medicines Partnership in Alzhiemer's disease (AMP-AD 2.0) are generating new datasets to extend the discoveries of the parent AMP-AD grants. These projects have a primary focus on diverse samples, and are examining gene expression at single-cell resolution, evaluating peripheral proteomic signatures, and characterizing signals of immunosenescence. We will support dissemination of these valuable research assets through the AD Knowledge Portal , which serves as an NIH designated repository to support the NIA's strategic goal to propagate data sharing under FAIR principles and to promote open science.