Data Coordination for the AMP Autoimmune and Related (AR) Knowledge Portal Part B

项目摘要/摘要 AMP-RA/SLE计划正在开发基因组变异、转录、细胞TOF和组织学数据 类风湿性关节炎和系统性红斑狼疮患者的疾病相关组织 红斑狼疮。本提案旨在扩大AMP-AD数据协调中心(AD- DCC)赠款(U24AG061340)，以支持AMP-RA/SLE活动的协调和传播 程序。具体地说，这项工作旨在扩大对AMP-RA/SLE正在开发的资源的访问 计划通过使用在AMP-AD计划中开发的系统、流程和技术来提高 在联合体内与研究界共享和更广泛地共享。由于数据结构上的相似性 在AMP-RA/SLE计划中收集的数据和当前托管的数据的结构之间 通过AMP-AD计划，使用补充机制为AMP-RA/SLE1提供快速支持 (U24AG061340-03S3)该提案建立在最初筹资期间为支持管理层所做的工作的基础上 通过支持上传新的第二阶段数据，扩展现有AMP-RA/SLE第一阶段和第二阶段资源 关于拟议的自身免疫及相关知识门户(方舟门户)的特点，并通过将 方舟门户，以适应未来AMP-AIM计划的要求。

Project Summary/Abstract The AMP-RA/SLE program is developing genomic variants, transcriptomics, CyTOF, and histology data on disease relevant tissue from individuals diagnosed with Rheumatoid Arthritis and Systemic Lupus Erythematosus. This proposal is designed to extend the work of the AMP-AD Data Coordination Center (AD- DCC) grant (U24AG061340) to support the coordination and dissemination of activities of the AMP-RA/SLE program. Specifically, this work aims to expand the access to resources being developed in the AMP-RA/SLE program by using the systems, processes and technology developed in the AMP-AD program to both increase within consortia sharing and broader sharing with the research community. Due to similarity in data structure being between collected in the AMP-RA/SLE program and the structure to the data currently being hosted through the AMP-AD program, a supplement mechanism was used to provide rapid support of AMP-RA/SLE1 (U24AG061340-03S3). This proposal builds on work done in the initial funding period to support the management of existing AMP-RA/SLE Phase I and Phase II resources by enabling upload of new Phase II data, expanding on features of the proposed Autoimmune and Related Knowledge Portal (ARK Portal), and by positioning the ARK Portal to accommodate requirements from the AMP-AIM program in the future.