Data Coordination for the AMP Autoimmune and Related (AR) Knowledge Portal Part B

AMP 自身免疫及相关 (AR) 知识门户 B 部分的数据协调

• 批准号: 10532648
• 负责人: ANNA K GREENWOOD
• 金额: $ 102万
• 依托单位: SAGE BIONETWORKS
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10532648
• 关键词: Autoimmune; Biopsy; Cells; Communities; Data; Data Coordinating Center; Diagnosis; Disease; Ecosystem; Funding; Future; Grant; Histology; Individual; Knowledge Portal; Lupus Nephritis; Medicine; Phase; Population; Positioning Attribute; Process; Research; Resources; Rheumatoid Arthritis; Structure; System; Systemic Lupus Erythematosus; Technology; Tissues; Work; data structure; design; genetic variant; high dimensionality; kidney biopsy; programs; transcriptomics

Project Summary/Abstract The AMP-RA/SLE program is developing genomic variants, transcriptomics, CyTOF, and histology data on disease relevant tissue from individuals diagnosed with Rheumatoid Arthritis and Systemic Lupus Erythematosus. This proposal is designed to extend the work of the AMP-AD Data Coordination Center (AD- DCC) grant (U24AG061340) to support the coordination and dissemination of activities of the AMP-RA/SLE program. Specifically, this work aims to expand the access to resources being developed in the AMP-RA/SLE program by using the systems, processes and technology developed in the AMP-AD program to both increase within consortia sharing and broader sharing with the research community. Due to similarity in data structure being between collected in the AMP-RA/SLE program and the structure to the data currently being hosted through the AMP-AD program, a supplement mechanism was used to provide rapid support of AMP-RA/SLE1 (U24AG061340-03S3). This proposal builds on work done in the initial funding period to support the management of existing AMP-RA/SLE Phase I and Phase II resources by enabling upload of new Phase II data, expanding on features of the proposed Autoimmune and Related Knowledge Portal (ARK Portal), and by positioning the ARK Portal to accommodate requirements from the AMP-AIM program in the future.

项目总结/摘要 AMP-RA/SLE项目正在开发基因组变异、转录组学、CyTOF和组织学数据， 来自被诊断患有风湿性关节炎和系统性狼疮的个体的疾病相关组织 红斑。该提案旨在扩展AMP-AD数据协调中心（AD- DCC）赠款（U24 AG 061340），以支持AMP-RA/SLE活动的协调和传播 程序.具体而言，这项工作的目的是扩大获得正在制定的资源在AMP-RA/SLE 通过使用AMP-AD计划中开发的系统、流程和技术， 在联盟内部共享和与研究界更广泛的共享。由于数据结构相似 介于AMP-RA/SLE程序中收集的数据和当前托管的数据结构之间 通过AMP-AD计划，使用了一种补充机制来提供AMP-RA/SLE 1的快速支持 （U24AG061340-03S3）。本提案以最初供资期间为支持管理层所做的工作为基础 现有AMP-RA/SLE I期和II期资源，支持上传新的II期数据， 建议的自身免疫和相关知识门户网站（方舟门户网站）的功能，并通过定位 方舟门户，以适应未来AMP-AIM计划的要求。