Data Coordination for the AMP Autoimmune and Related (AR) Knowledge Portal Part B

AMP 自身免疫及相关 (AR) 知识门户 B 部分的数据协调

• 批准号: 10532648
• 负责人: ANNA K GREENWOOD
• 金额: $ 102万
• 依托单位: SAGE BIONETWORKS
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10532648
• 关键词: Autoimmune; Biopsy; Cells; Communities; Data; Data Coordinating Center; Diagnosis; Disease; Ecosystem; Funding; Future; Grant; Histology; Individual; Knowledge Portal; Lupus Nephritis; Medicine; Phase; Population; Positioning Attribute; Process; Research; Resources; Rheumatoid Arthritis; Structure; System; Systemic Lupus Erythematosus; Technology; Tissues; Work; data structure; design; genetic variant; high dimensionality; kidney biopsy; programs; transcriptomics

Project Summary/Abstract The AMP-RA/SLE program is developing genomic variants, transcriptomics, CyTOF, and histology data on disease relevant tissue from individuals diagnosed with Rheumatoid Arthritis and Systemic Lupus Erythematosus. This proposal is designed to extend the work of the AMP-AD Data Coordination Center (AD- DCC) grant (U24AG061340) to support the coordination and dissemination of activities of the AMP-RA/SLE program. Specifically, this work aims to expand the access to resources being developed in the AMP-RA/SLE program by using the systems, processes and technology developed in the AMP-AD program to both increase within consortia sharing and broader sharing with the research community. Due to similarity in data structure being between collected in the AMP-RA/SLE program and the structure to the data currently being hosted through the AMP-AD program, a supplement mechanism was used to provide rapid support of AMP-RA/SLE1 (U24AG061340-03S3). This proposal builds on work done in the initial funding period to support the management of existing AMP-RA/SLE Phase I and Phase II resources by enabling upload of new Phase II data, expanding on features of the proposed Autoimmune and Related Knowledge Portal (ARK Portal), and by positioning the ARK Portal to accommodate requirements from the AMP-AIM program in the future.

项目摘要/摘要 AMP-RA/SLE程序正在开发基因组变异，转录组学，细胞和组织学数据 诊断出患有类风湿关节炎和全身性狼疮的人的疾病相关组织 红斑。该建议旨在扩展AMP-AD数据协调中心的工作（AD- DCC）赠款（U24AG061340）支持AMP-RA/SLE活动的协调和传播 程序。具体而言，这项工作旨在扩大对AMP-RA/SLE中正在开发的资源的访问 通过使用AMP-AD程序中开发的系统，流程和技术来进行程序来增加 在财团共享和与研究界的更广泛共享中。由于数据结构的相似性 在AMP-RA/SLE程序中的收集到当前托管的数据之间的结构之间 通过AMP-AD程序，使用补充机制来快速支持AMP-RA/SLE1 （U24AG061340-03S3）。该提案建立在最初的资助期间的工作以支持管理层的工作 通过上传新的II阶段数据，扩展 关于拟议的自身免疫和相关知识门户（ARK门户）的功能，并通过定位 方舟门户网站以适应将来的AMP-AIM计划的要求。