Exceptional Longevity Data Management and Coordinating Center

卓越长寿数据管理和协调中心

• 批准号: 10515786
• 负责人: ANNA K GREENWOOD
• 金额: $ 220.78万
• 依托单位: SAGE BIONETWORKS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10515786
• 关键词: Address; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Benchmarking; Biological; Catalogs; Cognitive; Collection; Communities; Complex; Data; Data Commons; Data Coordinating Center; Dementia; Development; Disease; Elderly; Environment; Evaluation; Evaluation Research; FAIR principles; Funding; Genetic; Goals; Health; Human; Individual; Infrastructure; Institution; Interdisciplinary Study; Knowledge; Knowledge Portal; Lead; Life; Longevity; Medicine; Meta-Analysis; Metabolism; Methods; Mission; Molecular; Molecular Profiling; National Institute on Aging; Outcomes Research; Physiological; Quality of life; Research; Research Design; Research Personnel; Research Project Grants; Resource Sharing; Resources; Risk Factors; Science; Structure; Synapses; Systems Biology; Training; Work; age related; base; burden of illness; data ecosystem; data harmonization; data integration; data management; data resource; data sharing; data standards; design; experience; genomic locus; healthy aging; human old age (65+); improved; interoperability; multiple omics; open data; programs; protective factors; resilience; tool; working group

Advanced age is the primary risk factor for developing dementia due to Alzheimer’s Disease (AD) and Alzheimer’s Disease Related Disorders (ADRD). Investigating the factors that contribute to healthy aging and exceptional long life represents an opportunity to reduce the burden of diseases of aging including Alzheimer’s and related dementias. To this end, the National Institute on Aging (NIA) has established four longevity translational projects working to identify genetic and other molecular signatures of long life and resilience to age-related diseases in humans and non-human species. Employing team science approaches to assemble the complementary approaches and expertise of the dozens of researchers across this network presents a powerful opportunity to extend and integrate this work by aggregating resources and knowledge across domains, including Alzheimer’s and related dementias. The overarching goal of the proposed Exceptional Longevity Data Management and Coordination Core (EL DMCC) is to aid the EL research community in these efforts by facilitating research on protective factors that contribute to exceptional health and resilience to age-related diseases like AD and ADRD. The DMCC will address this goal by (1) Establishing a dynamic catalog of EL data and resources, (2) Initiating cross-team analytical projects and data challenges to leverage expertise and data from across the EL projects and in conjunction with AD resilience projects, (3) Developing an EL Knowledge Portal to act as a central hub for EL research resources, and (4) Piloting a limited data commons to enable facile computation on EL and AD data within the cloud environment for EL investigators.

高龄是由于阿尔茨海默氏病（AD）和阿尔茨海默氏病有关的疾病（ADRD）而导致痴呆症的主要危险因素。调查导致健康衰老和出色长寿的因素是减少包括阿尔茨海默氏病和相关痴呆症在内的衰老疾病的机会。为此，美国国家老化研究所（NIA）建立了四个长寿的翻译项目，旨在识别长寿和对与年龄相关的疾病的遗传和其他分子特征。采用团队科学方法来组装该网络的数十个研究人员的完整方法和专业知识，这为扩展和整合这项工作提供了有力的机会，通过汇总包括阿尔茨海默氏症和相关痴呆症在内的领域的资源和知识。拟议的杰出寿命数据管理和协调核心（EL DMCC）的总体目标是通过支持对保护因素的研究，从而帮助EL研究社区来实现这些努力，从而有助于对与年龄相关的疾病（如AD和ADRD）的特殊健康和韧性。 DMCC将通过（1）建立EL数据和资源的动态目录来解决这一目标，（2）启动跨团队分析项目和数据挑战，以利用来自EL项目的专业知识和数据的专业知识和数据，以及与AD弹性项目的结合，（3）开发EL知识门户，以启用EL的EL EL范围，以启用EL EL的限制数据，并启用限制性数据量度（4）限制顾客的incould（4），请乘坐限制顾客的incould（4），请限制顾客的顾客，并在限制范围内（4）调查人员。