Building a next-generation AMP-AIM Data Management Core to maximize FAIR-ness of autoimmune and immune-mediated disease research resources

项目摘要/摘要 加速药物伙伴关系自身免疫和免疫介导性疾病(AMP-AIM)计划是 开发多样化的多组学和成像数据来研究多种疾病，包括类风湿性疾病 关节炎、系统性红斑狼疮、牛皮癣和干燥病 目的确定这些疾病的共同炎症途径和独特的分子基础。这 该提案旨在延长阿尔茨海默病加速药物伙伴关系(AMP- AD)数据协调中心(AD-DCC)赠款(U24AG061340)，支持协调和传播 AMP-AIM计划的资源。具体地说，这项工作的目的是扩大对 通过使用系统、流程和技术在AMP-AIM计划中开发的资源 在AMP-AD计划中开发，以增加财团内部的共享和与 研究社区。 由于在加速药物伙伴关系类风湿中收集的数据结构相似 关节炎和系统性红斑狼疮(AMP-RA/SLE)计划和目前正在进行的数据结构 通过AMP-AD计划，使用补充机制为AMP-AD提供快速支持- RA/SLE(U24AG061340-03S3)。第二个补充项目(U24AG061340-04S2)建立在 初步供资期限，以支持管理现有的AMP-RA/SLE第一阶段和第二阶段资源 支持上传新的第二阶段数据，扩展自身免疫和相关知识门户的功能 (方舟门户)，并定位方舟门户以适应AMP-AIM计划的要求。 该提案旨在建立我们所认为的“下一代”AMP-AIM数据管理核心(DMC) 最大化自身免疫和免疫介导性疾病研究资源的公平性。我们打算实现 这一愿景通过(1)发展AMP-AIM数据共享基础设施，同时提供持续的数据管理 支持建立标准驱动的研究生态系统；以及(2)增强方舟门户资源 传播，以实现基于标准的发现和重用。

PROJECT SUMMARY/ABSTRACT The Accelerating Medicines Partnership Autoimmune and Immune-Mediated Diseases (AMP-AIM) program is developing a diverse array of multi-omic and imaging data to study multiple diseases, including rheumatoid arthritis, systemic lupus erythematosus, psoriasis, psoriatic arthritis, and Sjögren's disease, with an overarching goal to identify common inflammatory pathways and unique molecular underpinnings to these diseases. This proposal is designed to extend the work of the Accelerating Medicines Partnership Alzheimer's Disease (AMP- AD) Data Coordination Center (AD-DCC) grant (U24AG061340) to support the coordination and dissemination of resources of the AMP-AIM program. Specifically, this work aims to expand the access to and enable reuse of resources being developed in the AMP-AIM program by using the systems, processes, and technology developed in the AMP-AD program to both increase within consortia sharing and broader sharing with the research community. Due to similarity in data structure being between collected in the Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP-RA/SLE) program and the structure of data currently being hosted through the AMP-AD program, a supplement mechanism was used to provide rapid support of AMP- RA/SLE (U24AG061340-03S3). A second supplement project (U24AG061340-04S2) built on work done in the initial funding period to support the management of existing AMP-RA/SLE Phase I and Phase II resources by enabling upload of new Phase II data, expanding on features of the Autoimmune and Related Knowledge Portal (ARK Portal), and positioning the ARK Portal to accommodate requirements from the AMP-AIM program. This proposal aims to establish what we view as a “next-generation” AMP-AIM Data Management Core (DMC) to maximize FAIR-ness of autoimmune and immune-mediated disease research resources. We intend to achieve this vision by (1) evolving the AMP-AIM data sharing infrastructure while providing continued data management support to establish a standards-driven research ecosystem; and (2) enhancing ARK Portal resource dissemination to enable standards-powered discovery and reuse.