Building a next-generation AMP-AIM Data Management Core to maximize FAIR-ness of autoimmune and immune-mediated disease research resources

构建下一代 AMP-AIM 数据管理核心，以最大限度地提高自身免疫和免疫介导疾病研究资源的公平性

• 批准号: 10900403
• 负责人: ANNA K GREENWOOD
• 金额: $ 50万
• 依托单位: SAGE BIONETWORKS
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10900403
• 关键词: Acceleration; Address; Alzheimer' s Disease; Autoimmune; Autoimmune Diseases; Biological Assay; Biology; Cells; Communities; Complement; Computer software; Data; Data Coordinating Center; Data Set; Development; Disease; Documentation; Ecosystem; Engineering; Ensure; FAIR principles; Feedback; Funding; Goals; Grant; Image; Immune; Immune System Diseases; Individual; Inflammatory; Infrastructure; Investigation; Knowledge Portal; Link; Mediating; Medicine; Metadata; Modality; Modernization; Molecular; Multiomic Data; Pathway interactions; Persons; Phase; Phenotype; Positioning Attribute; Process; Psoriasis; Psoriatic Arthritis; Publications; Published Comment; Research; Research Personnel; Resource Sharing; Resources; Rheumatoid Arthritis; Sampling; Sjogren' s Syndrome; Specific qualifier value; Standardization; Structure; Subjects Selections; Surface; System; Systemic Lupus Erythematosus; Technology; Tissues; Update; Validation; Vision; Work; clinically relevant; cohort; data exploration; data management; data sharing; data standards; data structure; data warehouse; design; flexibility; high dimensionality; member; multiple omics; next generation; programs; tool; virtual

PROJECT SUMMARY/ABSTRACT The Accelerating Medicines Partnership Autoimmune and Immune-Mediated Diseases (AMP-AIM) program is developing a diverse array of multi-omic and imaging data to study multiple diseases, including rheumatoid arthritis, systemic lupus erythematosus, psoriasis, psoriatic arthritis, and Sjögren's disease, with an overarching goal to identify common inflammatory pathways and unique molecular underpinnings to these diseases. This proposal is designed to extend the work of the Accelerating Medicines Partnership Alzheimer's Disease (AMP- AD) Data Coordination Center (AD-DCC) grant (U24AG061340) to support the coordination and dissemination of resources of the AMP-AIM program. Specifically, this work aims to expand the access to and enable reuse of resources being developed in the AMP-AIM program by using the systems, processes, and technology developed in the AMP-AD program to both increase within consortia sharing and broader sharing with the research community. Due to similarity in data structure being between collected in the Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP-RA/SLE) program and the structure of data currently being hosted through the AMP-AD program, a supplement mechanism was used to provide rapid support of AMP- RA/SLE (U24AG061340-03S3). A second supplement project (U24AG061340-04S2) built on work done in the initial funding period to support the management of existing AMP-RA/SLE Phase I and Phase II resources by enabling upload of new Phase II data, expanding on features of the Autoimmune and Related Knowledge Portal (ARK Portal), and positioning the ARK Portal to accommodate requirements from the AMP-AIM program. This proposal aims to establish what we view as a “next-generation” AMP-AIM Data Management Core (DMC) to maximize FAIR-ness of autoimmune and immune-mediated disease research resources. We intend to achieve this vision by (1) evolving the AMP-AIM data sharing infrastructure while providing continued data management support to establish a standards-driven research ecosystem; and (2) enhancing ARK Portal resource dissemination to enable standards-powered discovery and reuse.

项目摘要/摘要 加速的药物伙伴关系自身免疫和免疫介导的疾病（AMP-aim）计划是 开发一系列多摩尼和成像数据来研究多种疾病，包括类风湿病 关节炎，全身性红斑狼疮，牛皮癣，银屑病关节炎和Sjögren病，具有总体 目的是确定这些疾病的常见炎症途径和独特的分子基础。这 提案旨在扩大加速药品伙伴关系阿尔茨海默氏病的工作（amp-- AD）数据协调中心（AD-DCC）赠款（U24AG061340）支持协调和传播 AMP-AIM计划的资源。具体而言，这项工作旨在扩大对 通过使用系统，流程和技术，在AMP-AIM计划中开发资源 在AMP-AD计划中开发，以增加财团共享内部和与 研究社区。 由于数据结构的相似性，在加速药物合作伙伴的类风湿病之间 关节炎和全身性红斑狼疮（AMP-RA/SLE）程序以及目前正在的数据结构 通过AMP-AD计划托管，使用补充机制来快速支持AMP- RA/SLE（U24AG061340-03S3）。第二个补充项目（U24AG061340-04S2）建立在 最初的资金期限以支持现有AMP-RA/SLE I期和II期资源的管理 启用新的II阶段数据的上传，扩展自动免疫和相关知识门户的功能 （ARK Portal），并定位ARK门户，以适应AMP-AIM计划的要求。 该提案旨在确定我们认为的“下一代” AMP-AIM数据管理核心（DMC） 为了最大程度地提高自身免疫性和免疫介导的疾病研究资源的公平性。我们打算实现 通过（1）在提供持续数据管理的同时，通过（1）发展AMP-AIM数据共享基础架构 支持建立标准驱动的研究生态系统； （2）增强方舟门户资源 传播以实现标准驱动的发现和重复使用。