TB-RICC 3.0

TB-RICC 3.0

• 批准号: 10593544
• 负责人: BRUNO DE BEZERRIL ANDRADE
• 金额: $ 393.34万
• 依托单位: RUTGERS BIOMEDICAL AND HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10593544
• 关键词: Africa; Architecture; Area; Asia; Biological Markers; Biometry; Biotechnology; Brazil; COVID-19; China; Clinical; Clinical Research; Clinical Trials; Cohort Studies; Collaborations; Collection; Common Data Element; Communication; Country; Data; Data Collection; Data Element; Development; Diagnostic; Diagnostics Research; Elements; Ensure; Epidemiology; Feedback; Foundations; Generations; Geographic Locations; Goals; Grant; HIV/TB; Human; Immunology; India; Indonesia; International; Intervention Studies; Korea; Laboratories; Leadership; Logistics; Mentors; Monitor; Observational Study; Performance; Pharmaceutical Preparations; Population; Proteomics; Protocols documentation; Publishing; Quality Control; Research; Research Design; Research Methodology; Research Personnel; Research Support; Review Committee; Science; Site; South Africa; South America; Specimen; Structure; Technology; Translational Research; Treatment outcome; Tuberculosis; Vaccines; Validation; biobank; biomarker evaluation; data centers; data harmonization; data hub; data management; data standards; design; electronic data; falls; frontier; innovation; insight; learning materials; multiple omics; nano-string; novel diagnostics; predictive marker; programs; prospective; response; sample collection; tool; transcriptomics; tuberculosis diagnostics; working group

TB-RICC 3.0 is designed to support the Regional Prospective Observational Research Tuberculosis (RePORT) Consortium to produce the highest quality observational and interventional research on tuberculosis (TB), TB-HIV, and TB-COVID-19. To accomplish this goal, TB-RICC 3.0 will: i) collaborate with RePORT Country-Network Data Centers and Biorepositories to ensure that common data elements (CDE) of the Common Protocol and Specimen Tracking are accessible through the Global Data Template; ii) organize and/or strengthen select sites to participate in diagnostic studies and clinical trials; and iii) support the RePORT Country-Networks to ensure further development of TB diagnostic laboratories, TB- RICC 3.0 specialized laboratories, and biorepositories. Aims of TB-RICC 3.0 are: Coordinating Center Structure and Function: develop a Leadership Group and Executive Committee; assure effective communication internally and externally; establish a Data Hub to provide seamless data management from collection to analysis; establish Scientific Working Groups; a Scientific Review Committee and an Administrative Core; facilitate grant submissions to potential funders and partners. Data Harmonization: Develop a data hub to collaborate with country-level data centers to facilitate multiregional data workflow using the REDCap Harmonist platform and other tools; Research: catalyze TB, TB/HIV and TB/COVID-19 research within and across RePORT Country Networks, and with external partners; prioritize study of TB close contacts to evaluate biomarkers predictive of progression to TB across three “omics” platforms and three continents; Capacity Building: develop modular remote courses for capacity building in the components of TB research; Mentor early-stage investigator (ESI) development. TB-RICC 3.0 will deliver high-impact innovative research to advance TB Science and TB Control

TB-RICC 3.0旨在支持区域前瞻性观测研究