权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

The role of the cerebellum in speech

小脑在言语中的作用

基本信息

批准号：
10536611
负责人：
John Francis Houde
金额：
$ 62.23万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-12-25 至 2024-11-30
项目状态：
已结题

项目摘要

PROJECT SUMMARY This proposal investigates the role of the cerebellum in speech, building upon theoretical models and experimental methods that have proven useful in understanding cerebellar function in reaching and walking. Neuroimaging and lesion studies have provided compelling evidence that the cerebellum is an integral part of the speech production network, though its precise role in the control of speech remains unclear. Furthermore, damage to the cerebellum (either degenerative or focal) can lead to ataxic dysarthria, a motor speech disorder characterized, in part, by impaired articulation and severe temporal deficits. This grant seeks to bridge the gap between theoretical models of cerebellar function and the speech symptoms associated with ataxic dysarthria. Two mechanisms underlie speech motor control – feedback and feedforward control. In feedback control, speakers use sensory feedback (e.g., of their own voice) to control their speech. In feedforward control, speakers use knowledge gained from their past speech productions, rather than on-line feedback, to control their speech. This proposal entails a systematic plan to elucidate the role of the cerebellum in feedforward and feedback control of speech. A central hypothesis is that the cerebellum is especially critical in the feedforward control of speech, but has little involvement in feedback control. To explore this hypothesis, we will obtain converging evidence from three innovative methodologies: 1) Neuropsychological studies of speech-motor responses to real-time altered auditory feedback in patients with cerebellar atrophy (CA) and matched healthy controls, 2) Parallel studies in healthy controls undergoing theta-burst transcranial magnetic stimulation to create “virtual lesions” of the cerebellum, and 3) Structural and functional studies in CA patients to examine the relationship between cerebellar lesion location, dysarthria symptoms, and feedforward and feedback control ability. Speech provides an important opportunity to examine how well current theories of cerebellar function generalize to a novel effector (vocal tract) and sensory (auditory) domain. Its’ purpose for communication imposes exacting spectro-temporal constraints not seen in other motor domains. Furthermore, the distinctive balance of feedback and feedforward control in speech allows us to examine changes in both control types subsequent to cerebellar damage. Critically, this is the first work examining the link between theoretically- motivated control deficits in CA patients and the speech symptoms associated with ataxic dysarthria, as well as their neural correlates.

项目总结

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Increased speech contrast induced by sensorimotor adaptation to a nonuniform auditory perturbation.

感觉运动适应不均匀的听觉扰动引起的语音对比度增加。

DOI：
10.1152/jn.00466.2020
发表时间：
2021
期刊：
Journal of neurophysiology
影响因子：
2.5
作者：
Parrell,Benjamin;Niziolek,CarolineA
通讯作者：
Niziolek,CarolineA

Implicit reward-based motor learning.

DOI：
10.1007/s00221-023-06683-w
发表时间：
2023-09
期刊：
EXPERIMENTAL BRAIN RESEARCH
影响因子：
2
作者：
van Mastrigt, Nina M.;Tsay, Jonathan S.;Wang, Tianhe;Avraham, Guy;Abram, Sabrina J.;van der Kooij, Katinka;Smeets, Jeroen B. J.;Ivry, Richard B.
通讯作者：
Ivry, Richard B.

Signatures of contextual interference in implicit sensorimotor adaptation.