CRCNS: Modeling the role of auditory feedback in speech motor control

CRCNS：模拟听觉反馈在言语运动控制中的作用

• 批准号: 9763605
• 负责人: John Francis Houde
• 金额: $ 37.45万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9763605
• 关键词: Address; Affect; Apraxias; Auditory; Auditory area; Auditory system; Basic Science; Behavior; Brain; Cerebellar Ataxia; Clinical; Computer Simulation; Dementia; Diagnosis; Disease; Etiology; Feedback; Financial compensation; Functional Imaging; Future; Grant; Hearing; Impairment; Individual; Lead; Magnetoencephalography; Modality; Modeling; Monitor; Motor; Motor output; Output; Parkinson Disease; Patients; Play; Process; Production; Role; Schizophrenia; Sensory; Signal Transduction; Source; Spastic Dysphonias; Speech; Speech Delay; Speech Disorders; Study Subject; Stuttering; Testing; Work; auditory feedback; auditory processing; autism spectrum disorder; experimental study; imaging study; improved; lexical; motor control; phonology; response; role model

When we speak, listeners hear us and understand us we speak correctly. But we also hear ourselves, and this auditory feedback affects our ongoing speech: delaying it causes dysfluency; perturbing its pitch or formants induces compensation. Yet we can also speak intelligibly even when we can't hear ourselves. For this reason, most models of speech motor control suppose that during speaking auditory processing is only engaged when auditory feedback is available. In this grant, we propose to investigate a computational model of speaking that represents a major departure from this. Our model proposes that the auditory system always plays a major role in controlling speaking, regardless of whether auditory feedback is available. In our state-feedback control (SFC) model of speech production, we posit two things about the role of the auditory system. First, the auditory system continuously maintains an estimate of current vocal output. This estimate is derived not only from available auditory feedback, but also from multiple other sources of information, including motor efference, other sensory modalities, and phonological and lexical context. Second, this estimate of current vocal output is used both at a low level to monitor and correct ongoing speech motor output and at a higher level to regulate the production of utterance sequences. By comparing computational simulations of our model with functional imaging experiments, we will test key predictions from our computational model as they apply to a wide range of speech production - from production of single utterances to utterance sequences. The specific aims of this grant are (1) to demonstrate that auditory system continuously maintains an estimate of current vocal output, and (2) to determine how auditory feedback processing controls the production of utterance sequences. The proposed work not only addresses fundamentally important basic science questions about speech production, but also has broad clinical impact since abnormalities in auditory feedback processing are implicated in many speech impairments.

当我们说话时，听众会听到我们，理解我们，我们说得很正确。但我们也听到自己的声音，这种听觉反馈会影响我们正在进行的言语：延迟它会导致不流畅;扰乱它的音高或共振峰会引起补偿。然而，即使我们听不到自己的声音，我们也能说得清楚。由于这个原因，大多数言语运动控制模型都假设，在说话过程中，只有在听觉反馈可用的情况下，听觉处理才会进行。在这个补助金，我们建议调查一个计算模型的发言，代表了一个重大的偏离。我们的模型提出，听觉系统总是在控制说话中发挥着重要作用，无论听觉反馈是否可用。在我们的言语产生的状态反馈控制（SFC）模型中，我们解释了两件关于听觉系统作用的事情。首先，听觉系统持续保持对当前声音输出的估计。这种估计不仅来自可用的听觉反馈，而且来自多个其他信息源，包括运动传出，其他感觉方式，以及语音和词汇背景。第二，当前声音输出的这种估计在低水平上用于监视和校正正在进行的言语运动输出，并且在较高水平上用于调节话语序列的产生。通过将我们模型的计算模拟与功能成像实验进行比较，我们将测试我们计算模型的关键预测，因为它们适用于广泛的语音生产-从单个话语到话语序列的生产。本研究的目的是：（1）证明听觉系统持续保持对当前声音输出的估计;（2）确定听觉反馈处理如何控制话语序列的产生。这项研究不仅解决了有关语音产生的重要基础科学问题，而且具有广泛的临床影响，因为听觉反馈处理异常与许多语音障碍有关。