Unraveling the dynamic between alcohol use and consequences in college women: Modern perspectives on the menstrual cycle, advanced statistics, and team science strategies

项目摘要/摘要 尽管一生中饮酒总量比男性少，但饮酒的女性 经历无数与酒精有关的身体疾病、精神障碍、社交活动的风险增加 后果和受害。然而，研究发现了这些健康差距的生物学决定因素， 例如，女性月经周期中的荷尔蒙波动一直没有定论。这 应用程序寻求将提高月经研究严谨性的当代最佳实践引入 酒精研究。根据2019-2023年跨国家卫生研究院战略计划的目标1，“推进科学为 这个应用程序将使用新的分析方法来解开 女性个体月经周期模式、饮酒和近期后果。调查结果可能会确定 女性特有的因素(如使用荷尔蒙避孕药)和易受伤害的时间点(如某些月经 三个阶段)，从而可能增加饮酒和相关后果的风险。拟议的研究将 加强一项正在进行的为期两年的纵向研究(R01AA027017)，旨在表征大学的影响 饮酒及相关健康行为对心血管健康的影响。家长研究包括两个面对面的 实验室会议和每周的电子调查，衡量前一周的酒精使用行为。建议数 研究利用了来自父研究的样本、调查数据和非平衡负载概念框架 女性参与者，并增加了使用月经跟踪智能手机应用程序和排卵验证 检查酒精使用(目标1)和后果(目标2)是否受到影响 根据月经周期，以及它们之间的关联是否在多个周期中不同(目标3)。这个 拟议的研究还寻求将父母研究对酒精后果的评估扩展到更多 全面评估特定饮酒事件的风险水平。分层线性建模与时变 效果模型将用于评估酒精使用的动态和后果，并检查荷尔蒙。 避孕(一个经常被排除在外的因素)作为一种调节因素。申请者正在通过NIAAA F31申请 具体扩大她获得酒精研究方面广泛培训的机会的机制(培训 目标1)，这将补充她之前的生理学培训，并建立一条独立的研究路线 在酒精研究和女性健康的交叉点上。为完成建议的研究，申请人须 接受月经研究理论和设计(目标2)、密集的纵向数据分析方面的额外培训 (目标3)和专业发展(目标4)。这项研究和培训计划将为 申请人未来的研究方向，以检查有助于发展的生物、心理和社会因素 女性一生中的酒精使用问题和身体疾病。获得NRSA F31奖学金 将使申请者从时间密集的助教职位上解脱出来，有效地使她的时间增加一倍 可进行研究，并在酒精研究领域建立强大的专业网络。

PROJECT SUMMARY/ABSTRACT Despite consuming less total volume of alcohol over the lifespan than men, women who drink alcohol are at increased risk for experiencing a myriad of alcohol-related physical diseases, psychiatric disorders, social consequences, and victimization. Yet, research to uncover biological determinants of these health disparities, such as hormonal fluctuations that occur across women’s menstrual cycles, has been inconclusive. This application seeks to bring contemporary best practices for improving rigor of menstrual studies to the field of alcohol studies. In line with Goal 1 of the 2019-2023 Trans-NIH Strategic Plan, “Advancing Science for the Health of Women,” this application will use novel analytical approaches to unravel the dynamics between women’s individual menstrual cycle patterns, alcohol use, and proximal consequences. Findings may identify female-specific factors (e.g., hormonal contraceptive use) and vulnerable time points (e.g., certain menstrual phases) whereby risk for alcohol use and related consequences may be heightened. The proposed study will augment an ongoing 2-year longitudinal study (R01AA027017) aimed at characterizing the effects of college drinking and related health behaviors on cardiovascular health. The parent study includes two in-person laboratory sessions and weekly e-surveys that gauge the prior week’s alcohol use behaviors. The proposed study leverages the sample, survey data, and allostatic load conceptual framework from the parent study’s female participants and adds the use of a menstrual tracking smartphone application and ovulation verification across 3 menstrual cycles to examine whether alcohol use (Aim 1) and consequences (Aim 2) are influenced by the menstrual cycle, and whether the association between them varies across multiple cycles (Aim 3). The proposed study also seeks to expand the parent’s study’s assessment of alcohol consequences to more comprehensively assess risk levels of given drinking episodes. Hierarchical linear modeling and time-varying effect models will be used to evaluate the dynamics of alcohol use and consequences and examine hormonal contraception (an often-excluded factor) as a moderator. The applicant is applying through the NIAAA F31 mechanism to specifically expand her opportunities to obtain extensive training in alcohol studies (Training Goal 1), which will complement her prior training in physiology, and establish an independent line of research at the intersection of alcohol studies and women’s health. To complete the proposed study, the applicant will receive additional training in menstrual study theory and design (Goal 2), intensive longitudinal data analysis (Goal 3), and professional development (Goal 4). The research and training plan will lay the foundation for the applicant’s future line of research to examine biopsychosocial factors that contribute to the development of alcohol use problems and physical disease in women across the lifespan. Receiving the NRSA F31 fellowship will relieve the applicant from her time-intensive teaching assistant position to effectively double her time available to conduct research and establish a strong professional network within the field of alcohol studies.