Unraveling the dynamic between alcohol use and consequences in college women: Modern perspectives on the menstrual cycle, advanced statistics, and team science strategies

揭示大学女性饮酒及其后果之间的动态：月经周期的现代观点、先进的统计数据和团队科学策略

• 批准号: 10537284
• 负责人: Kelsey Piersol
• 金额: $ 3.69万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10537284
• 关键词: Adverse effects; Alcohol abuse; Alcohol consumption; Alcohols; Behavior; Biological; Cardiovascular Diseases; Cognitive; Complement; Consumption; Contraceptive Usage; Data; Data Analyses; Development; Disease; Dissection; Emotional; Environment; Exhibits; Failure; Fellowship; Female; Foundations; Frequencies; Future; Goals; Health; Health Sciences; Health behavior; Heavy Drinking; Home; Hormonal; Individual; Knowledge; Laboratories; Linear Models; Longevity; Longitudinal Studies; Luteinizing Hormone; Malignant Neoplasms; Menstrual cycle; Mental disorders; Methods; Modeling; Modernization; Monitor; National Institute on Alcohol Abuse and Alcoholism; National Research Service Awards; Ovulation; Parents; Participant; Patient Self-Report; Pattern; Periodicity; Persons; Phase; Physiology; Positioning Attribute; Public Health; Reporting; Research; Research Personnel; Research Training; Risk; Sampling; Science; Strategic Planning; Surveys; Techniques; Time; Time Study; Training; United States National Institutes of Health; Victimization; Woman; Women' s Health; alcohol consequences; alcohol research; alcohol risk; allostatic load; base; biopsychosocial factor; cardiovascular health; career networking; college; college drinker; college drinking; cost; design; drinking; emerging adult; experience; health disparity; hormonal contraception; improved; men; mobile application; novel; perimenstrual; person centered; physical conditioning; prospective; protective effect; recruit; sex; smartphone Application; social; statistics; teaching assistant; test strip; theories; young woman

PROJECT SUMMARY/ABSTRACT Despite consuming less total volume of alcohol over the lifespan than men, women who drink alcohol are at increased risk for experiencing a myriad of alcohol-related physical diseases, psychiatric disorders, social consequences, and victimization. Yet, research to uncover biological determinants of these health disparities, such as hormonal fluctuations that occur across women’s menstrual cycles, has been inconclusive. This application seeks to bring contemporary best practices for improving rigor of menstrual studies to the field of alcohol studies. In line with Goal 1 of the 2019-2023 Trans-NIH Strategic Plan, “Advancing Science for the Health of Women,” this application will use novel analytical approaches to unravel the dynamics between women’s individual menstrual cycle patterns, alcohol use, and proximal consequences. Findings may identify female-specific factors (e.g., hormonal contraceptive use) and vulnerable time points (e.g., certain menstrual phases) whereby risk for alcohol use and related consequences may be heightened. The proposed study will augment an ongoing 2-year longitudinal study (R01AA027017) aimed at characterizing the effects of college drinking and related health behaviors on cardiovascular health. The parent study includes two in-person laboratory sessions and weekly e-surveys that gauge the prior week’s alcohol use behaviors. The proposed study leverages the sample, survey data, and allostatic load conceptual framework from the parent study’s female participants and adds the use of a menstrual tracking smartphone application and ovulation verification across 3 menstrual cycles to examine whether alcohol use (Aim 1) and consequences (Aim 2) are influenced by the menstrual cycle, and whether the association between them varies across multiple cycles (Aim 3). The proposed study also seeks to expand the parent’s study’s assessment of alcohol consequences to more comprehensively assess risk levels of given drinking episodes. Hierarchical linear modeling and time-varying effect models will be used to evaluate the dynamics of alcohol use and consequences and examine hormonal contraception (an often-excluded factor) as a moderator. The applicant is applying through the NIAAA F31 mechanism to specifically expand her opportunities to obtain extensive training in alcohol studies (Training Goal 1), which will complement her prior training in physiology, and establish an independent line of research at the intersection of alcohol studies and women’s health. To complete the proposed study, the applicant will receive additional training in menstrual study theory and design (Goal 2), intensive longitudinal data analysis (Goal 3), and professional development (Goal 4). The research and training plan will lay the foundation for the applicant’s future line of research to examine biopsychosocial factors that contribute to the development of alcohol use problems and physical disease in women across the lifespan. Receiving the NRSA F31 fellowship will relieve the applicant from her time-intensive teaching assistant position to effectively double her time available to conduct research and establish a strong professional network within the field of alcohol studies.

项目总结/摘要 尽管在一生中饮酒总量比男性少，但饮酒的女性 增加了经历无数与酒精有关的身体疾病、精神障碍、社交障碍的风险。 后果和受害。然而，揭示这些健康差异的生物决定因素的研究， 例如女性月经周期中的荷尔蒙波动，一直没有定论。这 应用程序旨在将当代改善月经研究严谨性的最佳实践带到 酒精研究根据2019-2023年跨NIH战略计划的目标1，“推进科学， 该应用程序将使用新的分析方法来揭示女性健康之间的动态关系。 女性个体的月经周期模式，酒精使用和近端后果。调查结果可以确定 女性特有的因素（例如，激素避孕药的使用）和脆弱的时间点（例如，某些月经 阶段），其中酒精使用和相关后果的风险可能会增加。拟定的研究将 补充一项正在进行的2年纵向研究（R 01 AA 027017），旨在描述大学教育的影响 饮酒及相关健康行为对心血管健康的影响。父母研究包括两个人 实验室会议和每周电子调查，衡量前一周的酒精使用行为。拟议 研究利用了来自母研究的样本、调查数据和非稳态负荷概念框架， 女性参与者，并添加了月经跟踪智能手机应用程序和排卵验证的使用 在3个月经周期中，检查饮酒（目标1）和后果（目标2）是否受到影响 月经周期，以及它们之间的关联是否在多个周期中变化（目标3）。的 一项拟议中的研究还试图将父母对酒精后果的评估扩大到更多 全面评估特定饮酒事件的风险水平。分层线性建模与时变 效应模型将用于评估酒精使用的动态和后果，并检查激素水平。 避孕（一个经常被排除的因素）作为调节因素。申请人通过NIAAA F31申请 一个专门扩大她获得酒精研究方面广泛培训的机会的机制（培训 目标1），这将补充她之前在生理学方面的培训，并建立一个独立的研究路线 酒精研究和女性健康的交叉点。为完成建议的研究，申请人须 接受月经研究理论和设计方面的额外培训（目标2），密集的纵向数据分析 (Goal 3）和专业发展（目标4）。研究和培训计划将为 申请人未来的研究方向，以检查有助于发展的生物心理社会因素， 酒精使用问题和身体疾病的妇女在整个生命周期。获得NRSA F31奖学金 将使申请人从时间密集的助教职位上解脱出来，有效地将她的时间增加一倍 可进行研究，并在酒精研究领域建立强大的专业网络。