Unraveling the dynamic between alcohol use and consequences in college women: Modern perspectives on the menstrual cycle, advanced statistics, and team science strategies

揭示大学女性饮酒及其后果之间的动态：月经周期的现代观点、先进的统计数据和团队科学策略

• 批准号: 10709515
• 负责人: Kelsey Piersol
• 金额: $ 3.79万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10709515
• 关键词: Adverse effects; Alcohol abuse; Alcohol consumption; Alcohols; Behavior; Biological; Cardiovascular Diseases; Cognitive; Complement; Consumption; Contraceptive Usage; Data; Data Analyses; Development; Disease; Dissection; Emotional; Environment; Exclusion; Exhibits; Failure; Fellowship; Female; Foundations; Frequencies; Future; Goals; Health; Health Sciences; Health behavior; Heavy Drinking; Home; Hormonal; Individual; Knowledge; Laboratories; Linear Models; Longevity; Longitudinal Studies; Luteinizing Hormone; Malignant Neoplasms; Menstrual cycle; Mental disorders; Methods; Modeling; Modernization; Monitor; National Institute on Alcohol Abuse and Alcoholism; National Research Service Awards; Ovulation; Parents; Participant; Patient Self-Report; Pattern; Periodicity; Persons; Phase; Physiology; Positioning Attribute; Public Health; Recommendation; Reporting; Research; Research Personnel; Risk; Risk Assessment; Sampling; Science; Strategic Planning; Surveys; Techniques; Time; Time Study; Training; United States National Institutes of Health; Victimization; Woman; Women' s Health; alcohol consequences; alcohol research; alcohol risk; allostatic load; biopsychosocial factor; cardiovascular health; career networking; college; college drinker; college drinking; cost; design; drinking; emerging adult; experience; health determinants; health disparity; hormonal contraception; improved; men; mobile application; novel; perimenstrual; person centered; physical conditioning; prospective; protective effect; recruit; sex; smartphone application; social; statistics; teaching assistant; test strip; theories; young woman

PROJECT SUMMARY/ABSTRACT Despite consuming less total volume of alcohol over the lifespan than men, women who drink alcohol are at increased risk for experiencing a myriad of alcohol-related physical diseases, psychiatric disorders, social consequences, and victimization. Yet, research to uncover biological determinants of these health disparities, such as hormonal fluctuations that occur across women’s menstrual cycles, has been inconclusive. This application seeks to bring contemporary best practices for improving rigor of menstrual studies to the field of alcohol studies. In line with Goal 1 of the 2019-2023 Trans-NIH Strategic Plan, “Advancing Science for the Health of Women,” this application will use novel analytical approaches to unravel the dynamics between women’s individual menstrual cycle patterns, alcohol use, and proximal consequences. Findings may identify female-specific factors (e.g., hormonal contraceptive use) and vulnerable time points (e.g., certain menstrual phases) whereby risk for alcohol use and related consequences may be heightened. The proposed study will augment an ongoing 2-year longitudinal study (R01AA027017) aimed at characterizing the effects of college drinking and related health behaviors on cardiovascular health. The parent study includes two in-person laboratory sessions and weekly e-surveys that gauge the prior week’s alcohol use behaviors. The proposed study leverages the sample, survey data, and allostatic load conceptual framework from the parent study’s female participants and adds the use of a menstrual tracking smartphone application and ovulation verification across 3 menstrual cycles to examine whether alcohol use (Aim 1) and consequences (Aim 2) are influenced by the menstrual cycle, and whether the association between them varies across multiple cycles (Aim 3). The proposed study also seeks to expand the parent’s study’s assessment of alcohol consequences to more comprehensively assess risk levels of given drinking episodes. Hierarchical linear modeling and time-varying effect models will be used to evaluate the dynamics of alcohol use and consequences and examine hormonal contraception (an often-excluded factor) as a moderator. The applicant is applying through the NIAAA F31 mechanism to specifically expand her opportunities to obtain extensive training in alcohol studies (Training Goal 1), which will complement her prior training in physiology, and establish an independent line of research at the intersection of alcohol studies and women’s health. To complete the proposed study, the applicant will receive additional training in menstrual study theory and design (Goal 2), intensive longitudinal data analysis (Goal 3), and professional development (Goal 4). The research and training plan will lay the foundation for the applicant’s future line of research to examine biopsychosocial factors that contribute to the development of alcohol use problems and physical disease in women across the lifespan. Receiving the NRSA F31 fellowship will relieve the applicant from her time-intensive teaching assistant position to effectively double her time available to conduct research and establish a strong professional network within the field of alcohol studies.

项目概要/摘要 尽管女性一生中饮酒总量少于男性，但饮酒的女性 罹患多种与酒精相关的身体疾病、精神疾病、社交障碍的风险增加 后果和受害。然而，研究揭示了这些健康差异的生物决定因素， 例如女性月经周期中发生的荷尔蒙波动，目前尚无定论。这 该应用旨在将提高月经研究严谨性的当代最佳实践引入到以下领域： 酒精研究。根据 2019-2023 年跨 NIH 战略计划的目标 1，“推进科学发展 女性健康”，该应用程序将使用新颖的分析方法来揭示两者之间的动态 女性的个人月经周期模式、饮酒情况和近期后果。研究结果可能会确定 女性特有因素（例如，激素避孕药的使用）和易受影响的时间点（例如，某些月经 阶段），由此可能会增加饮酒风险和相关后果。拟议的研究将 加强正在进行的为期 2 年的纵向研究 (R01AA027017)，旨在描述大学的影响 饮酒和相关健康行为对心血管健康的影响。家长研究包括两项面对面的研究 实验室会议和每周电子调查，衡量前一周的饮酒行为。拟议的 研究利用了母研究中的样本、调查数据和非稳态负荷概念框架 女性参与者并添加了月经跟踪智能手机应用程序和排卵验证的使用 跨越 3 个月经周期，检查饮酒（目标 1）和后果（目标 2）是否受到影响 月经周期，以及它们之间的关联是否在多个周期中变化（目标 3）。这 拟议的研究还试图将家长研究对酒精后果的评估扩大到更多 全面评估特定饮酒事件的风险水平。分层线性建模和时变 效应模型将用于评估饮酒的动态及其后果并检查荷尔蒙 避孕（经常被排除的因素）作为调节因素。申请人通过 NIAAA F31 申请 专门扩大她获得酒精研究广泛培训的机会的机制（培训 目标 1)，这将补充她之前的生理学培训，并建立独立的研究路线 在酒精研究和女性健康的交叉点。为了完成拟议的研究，申请人将 接受月经研究理论和设计（目标 2）、强化纵向数据分析方面的额外培训 （目标 3）和专业发展（目标 4）。研究和培训计划将为 申请人未来的研究方向，以检查有助于发展的生物心理社会因素 女性一生中的饮酒问题和身体疾病。获得 NRSA F31 奖学金 将使申请人从耗时的助教职位中解脱出来，从而有效地使她的时间加倍 可在酒精研究领域进行研究并建立强大的专业网络。