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Division of Chemical Toxicology Symposia at the 264th National ACS Meeting

第264届全国ACS会议化学毒理学研讨会分部

基本信息

批准号：
10539147
负责人：
Michael A Trakselis
金额：
$ 0.8万
依托单位：
BAYLOR UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-08 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10539147
关键词：
Academia Allergens American Area Artificial Intelligence Award Biochemistry Biological Products Biology COVID-19 Chemicals Chicago Collaborations Communities DNA Repair Development Disease Drug Design Drug toxicity Environmental Health Faculty Fostering Funding Goals Hazard Identification Health Human In Vitro Industrialization Industry Journals Knowledge Leadership Lesion Methods Mission Molecular National Institute of Environmental Health Sciences Oral Outcome Pharmaceutical Chemistry Pharmaceutical Preparations Pharmacologic Substance Policies Process Publishing Research Research Methodology Research Personnel Risk Assessment Role Safety Scientist Societies Students Therapeutic Toxic effect Toxicology Travel United States National Institutes of Health Writing career career development computational chemistry drug discovery environmental agent environmental toxicology falls genome-wide graduate student hazard improved in silico interest learning network medical specialties medication safety meetings novel posters programs repaired respiratory response safety assessment student mentoring symposium welfare

项目摘要

Project Summary/Abstract The goal of this application is to obtain support for the American Chemical Society Division of Chemical Toxicology (TOXI) at the 264th 2022 National Meeting program, which will be held August 21-25, 2022, in Chicago, IL. The mission of the Division of Chemical Toxicology is to improve human health and public welfare by promoting the understanding of chemical mechanisms that govern disease processes and the toxicity of drugs, environmental agents, and endogenous chemicals. The Fall 2022 programming will focus on the “molecular mechanisms and predictions of environmental toxicological responses”. Our goals include providing a forum for communicating research in the field of chemical toxicology, encouraging research in chemical mechanisms of toxicity, and facilitating connections between academia, industry, and policy in scientific areas of mutual interest, as well as leadership and professional development of scientists at all levels. Thus, the requested funds will be used to support travel awards and expenses for graduate students, postdoctoral scholars, and junior faculty. The overall program is organized around the theme of “molecular mechanisms and predictions of environmental toxicological responses”. The program includes four thematic symposia, which will feature invited oral presentations by a diverse group of established and emerging investigators with a range of perspectives on each topic. The four thematic symposia are: (1) “A Developing Role for Artificial Intelligence (AI) in Drug Discovery in Drug Design, Development, and Safety Assessment”, co-promoted by the Divisions of Medicinal Chemistry (MEDI) and Computational Chemistry (COMP), will explore the role of AI in toxicological hazard identification and risk assessment; (2) “Current Approaches to COVID-19 Drug Discovery and Safety Assessment”, co-promoted with MEDI, will examine the therapeutic spectrum of pharmaceuticals and biologics and their associated safety efficacies; (3) “Mechanism-Driven Hazard Identification of Chemical Respiratory Allergens,” focuses on recent progress in development of in silico and in vitro methods to identify respiratory sensitizers and hazards; (4) “Chemical Biology of DNA Damage and Repair”, copromoted with the Division of Biological Chemistry (BIOL), describes recent advances in chemical biology approaches used to characterize the distribution of genome-wide lesions and molecular mechanisms of repair outcomes. The scientific program is clearly aligned with the mission of NIEHS.

项目总结/摘要本申请的目的是获得美国化学会化学部的支持，毒理学（TOXI）在2022年8月21日至25日举行的第264届2022年全国会议计划，伊利诺伊州芝加哥化学毒理学司的使命是改善人类健康和公众健康，通过促进对控制疾病过程的化学机制的理解，药物、环境因子和内源性化学物质的毒性。2022年秋季节目将重点关注关于“环境毒理学反应的分子机制和预测”。我们的目标包括为交流化学毒理学领域的研究提供了一个论坛，毒性的化学机制，并促进学术界，工业界和政策之间的联系，共同感兴趣的科学领域，以及科学家的领导和专业发展，程度.因此，申请的资金将用于支持研究生的旅费和费用，博士后学者和初级教员。整个节目围绕“分子环境毒理学反应的机制和预测”。该计划包括四个主题专题讨论会，其中将包括由不同群体的既定和新兴的邀请口头介绍研究人员对每个主题都有一系列的观点。四个专题研讨会分别是：（1）“发展中的人工智能（AI）在药物设计、开发和安全性评估中的药物发现作用”，由药物化学（MEDI）和计算化学（COMP）部门共同推动，将探讨人工智能在毒理学危害识别和风险评估中的作用;（2）“当前的方法，与MEDI共同推广的“COVID-19药物发现和安全性评估”将检查治疗药物药物和生物制剂的范围及其相关的安全性功效;（3）“机制驱动化学性呼吸道过敏原的危害识别》，重点介绍了鉴定呼吸道致敏物和危害的计算机和体外方法;（4）“DNA的化学生物学损伤与修复”，与生物化学部（BIOL）共同推广，描述了最近的用于表征全基因组病变分布的化学生物学方法的进展，修复结果的分子机制。该科学计划显然与科学的使命一致， NIEHS