The Role of Sleep and Community-Level Supports in the Association between Racial Discrimination and Cardiometabolic Health in Black Adolescents

睡眠和社区层面的支持在黑人青少年种族歧视与心脏代谢健康之间的关联中的作用

• 批准号: 10537968
• 负责人: Jelaina Ruth Shipman
• 金额: $ 4.62万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10537968
• 关键词: 12 year old; Address; Adolescence; Adolescent; Adolescent Development; Adult; Black Populations; Black race; Blood Pressure; Body mass index; Brain; Buffers; Child Health; Cholesterol; Chronic; Communities; Data; Data Set; Development; Discrimination; Environment; Family; Fellowship; Goals; Health; Heart Diseases; Hypertension; Inflammation; Insulin Resistance; Intervention; Knowledge; Life Cycle Stages; Literature; Longevity; Longitudinal Studies; Measures; Mediating; Mediator of activation protein; Mental Health; National Heart, Lung, and Blood Institute; National Research Service Awards; Nature; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Parents; Pathway interactions; Patient Self-Report; Physiological; Play; Reporting; Research; Research Personnel; Research Training; Resources; Risk; Role; Sampling; Sleep; Sleep disturbances; Social Controls; Social Environment; Stress and Coping; Testing; Underserved Population; United States; Youth; aged; base; behavioral outcome; cardiogenesis; cardiometabolic risk; cardiometabolism; cognitive development; cohesion; cohort; community intervention; community-level factor; experience; follow-up; health disparity; heart disease risk; improved; interest; neighborhood safety; physical conditioning; poor sleep; pre-doctoral; preventive intervention; psychosocial; racial discrimination; racial disparity; racism; school environment; secondary analysis; skills; sleep difficulty; sleep quality; social; stressor; waist circumference

PROJECT SUMMARY Black adolescents are at an increased risk of poor cardiometabolic health during both adolescence and later adulthood, including obesity, hypertension, and type 2 diabetes. These cardiometabolic outcomes put Black youth at an increased risk for the development of heart disease, which kills Black adults at twice the rate of White adults. Racial discrimination and poor sleep are theorized as key factors contributing to cardiometabolic health. While studies in adults suggest that sleep may serve as a pathway through which discrimination influences cardiometabolic health, there is a critical gap in our knowledge of this pathway in adolescents. In contrast, community level-supports may protect Black youth against stressors, including the influence of racism and poor sleep. However, studies of the protective nature of community supports have largely focused on psychosocial and behavioral outcomes. Thus, research is needed to examine community-level supports as protective against the impact of racism on poor sleep and cardiometabolic outcomes; and the impact of poor sleep on cardiometabolic outcomes in Black youth. The goal of the proposed study is to examine the role of sleep and community support in the association of racial discrimination and cardiometabolic risk in Black adolescents. This application is responsive to NHLBI’s interest in research promoting cardiometabolic health in the early stages of the life course, including adolescence (NOT-HL-21-020). The aims will be addressed through secondary analysis of a nationally representative sample of Black adolescents, aged 11-12 years old, from the second-year follow-up of the Adolescent Brain Cognitive Development (ABCD) study, the largest long- term study of brain development and child health in the United States. The specific aims are to: (1): test sleep as a mediator of the association between racial discrimination and cardiometabolic risk in Black adolescents, and (2) test community support as a moderator of the associations among racial discrimination, sleep and cardiometabolic risk in Black adolescents. Addressing gaps in our understanding of how sleep and community- level supports contribute to cardiometabolic outcomes in Black adolescents will aid in the development of prevention interventions to promote long-term cardiometabolic health for Black individuals across the lifespan. Further, the research and training outlined in this NRSA F31 pre-doctoral fellowship application will equip me with the necessary skills and support needed to become an independent health disparities researcher with a focus on developing and evaluating strength-based community-level interventions to address health disparities among underserved populations.

项目摘要 黑人青少年在青春期及以后心脏代谢健康状况不佳的风险增加 成年期，包括肥胖，高血压和2型糖尿病。这些心脏代谢结果使布莱克 年轻人患心脏病的风险增加，黑人成年人的死亡率是黑人的两倍。 白色成年人。种族歧视和睡眠不足被认为是导致心脏代谢紊乱的关键因素。 健康虽然对成年人的研究表明，睡眠可能是一种途径， 影响心脏代谢健康，我们对青少年这一途径的认识存在重大差距。在 相比之下，社区一级的支持可能会保护黑人青年免受压力，包括种族主义的影响 睡眠不好。然而，对社区支持的保护性质的研究主要集中在 心理社会和行为结果。因此，需要进行研究，审查社区一级的支助， 保护免受种族主义对睡眠不良和心脏代谢结果的影响; 睡眠对黑人青年心脏代谢结果的影响拟议研究的目标是审查 睡眠和社区支持与黑人种族歧视和心脏代谢风险的关系 青少年。此应用程序是响应NHLBI的研究促进心脏代谢健康的兴趣， 生命过程的早期阶段，包括青春期（NOT-HL-21-020）。目标将得到解决 通过对全国有代表性的11-12岁黑人青少年样本的二次分析， 从青少年大脑认知发展（ABCD）研究的第二年随访中， 在美国的大脑发育和儿童健康的长期研究。具体目的是：（1）：测试睡眠 作为黑人青少年中种族歧视与心脏代谢风险之间关联的中介， 和（2）测试社区支持作为种族歧视，睡眠和 黑人青少年的心脏代谢风险解决我们对睡眠和社区如何理解的差距- 水平的支持有助于黑人青少年的心脏代谢结果， 预防干预措施，以促进黑人个体在整个生命周期的长期心脏代谢健康。 此外，在这个NRSA F31博士前奖学金申请概述的研究和培训将装备我 与必要的技能和支持，需要成为一个独立的健康差距研究员， 重点发展和评估基于实力的社区一级干预措施，以解决健康差距 在服务不足的人群中。