Understanding host-microbiome signalling axes in ageing

了解衰老过程中的宿主-微生物组信号轴

• 批准号: FL200100220
• 负责人: Prof Elaine Holmes
• 金额: $ 239.53万
• 依托单位: Murdoch University
• 依托单位国家: 澳大利亚
• 项目类别: Australian Laureate Fellowships
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-02-01 至 2026-01-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FL200100220
• 关键词: Understanding; host; microbiome; signalling; axes

Ageing is an inevitable biological phenomenon and is characterised by alterations in multiple biochemical, immunological and mechanical processes, which are influenced by the gut bacteria. Poor ageing exerts a heavy socioeconomic burden both nationally and globally. The aim of this proposal is to deepen understanding of host-microbiome signalling in ageing by bringing together next generation sequencing technologies to characterise age-associated change in gut bacterial composition, metabolic profiling to identify changes in functionality of the ageing microbiome and a combination of in vitro and in vivo screening approaches to establish molecular mechanisms. The new knowledge will facilitate development of improved models of health care.

衰老是一种不可避免的生物学现象，其特征是受肠道细菌影响的多种生物化学，免疫学和机械过程的改变。贫穷的老龄化给国家和全球带来沉重的社会经济负担。该提案的目的是加深对衰老中宿主微生物组信号传导的理解，将下一代测序技术与肠道细菌组成的衰老相关变化、代谢谱分析以确定衰老微生物组功能的变化以及体外和体内筛选方法的组合以建立分子机制。这些新知识将有助于发展更好的保健模式。